公开(公告)号：US09220827B2

公开(公告)日：2015-12-29

申请号：US13816968

申请日：2011-08-17

申请人： Joern Meibaum ,  Stefan Moll ,  Alex Castellarnau

发明人： Joern Meibaum ,  Stefan Moll ,  Alex Castellarnau

IPC分类号： A61M37/00 ,  A61M1/14 ,  A61M1/16 ,  G01N21/33

CPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/361 ,  A61M1/3612 ,  A61M2202/0498 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/52 ,  G01N21/33

摘要： The invention describes an apparatus for extracorporeal blood treatment with a dialyzer which is separated by a semipermeable membrane in to a first and second chamber (29, 30), wherein the first chamber (29) is arrange in a dialysate pathway and the second chamber (30) is connectable to the blood circulation of a patient by means of a blood supply conduit (32) and a blood return conduit (31), an inlet (20) for fresh dialysate, an outlet (30) for spent dialysate, a measuring device (37) arranged in the outlet (36), wherein said measuring device (37) has at least one radiation source consisting of several light sources (1) for electromagnetic radiation. The invention is characterized in that the measuring device (37) is designed to generate substantially monochromatic electromagnetic radiation of different wavelengths, and to lead only one of these wavelength (at the same time) though the outlet (36) for spent dialysate, wherein at least one detector system (5) is provided for detection of the intensity or the absorption of the substantially monochromatic electromagnetic radiation passing through the outlet (36) for spent dialysate.

摘要翻译： 本发明描述了一种用透析器进行体外血液处理的装置，其由半透膜分隔到第一和第二腔室（29,30）中，其中第一腔室（29）布置在透析液通路中，第二腔室 30）可通过血液供应管道（32）和血液回流管道（31），用于新鲜透析液的入口（20），用于透析液的出口（30），血液透析液 设置在所述出口（36）中的装置（37），其中所述测量装置（37）具有由用于电磁辐射的多个光源（1）组成的至少一个辐射源。 本发明的特征在于，测量装置（37）被设计成产生不同波长的基本上单色的电磁辐射，并且仅通过用于废透析液的出口（36）仅引导这些波长（同时）中的一个波长（其中在 提供了至少一个检测器系统（5），用于检测通过用于透析液的出口（36）的基本上单色的电磁辐射的强度或吸收。

公开(公告)号：US20120217189A1

公开(公告)日：2012-08-30

申请号：US13394021

申请日：2010-09-06

申请人： Jörn Ahrens ,  Stefan Moll ,  Alex Castellarnau

发明人： Jörn Ahrens ,  Stefan Moll ,  Alex Castellarnau

IPC分类号： A61M1/16

CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M2205/3313 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2205/52

摘要： The invention is related to an apparatus for extracorporeal treatment of blood with a dialyzer which is separated by a semipermeable membrane into a first and a second chamber, wherein the first chamber is disposed in a dialysis fluid pathway and the second chamber is connectable to the blood circulation of a patient by means of a blood inflow conduit and a blood outflow conduit, a feed for fresh dialysis fluid, a discharge for spent dialysis fluid, a means for estimation of a flow QBlood in the blood inflow conduit respectively the blood outflow conduit, a means for determining a flow QDialysate in the dialysis fluid pathway, and a measuring device disposed in the discharge for estimation of the absorption ADialysate of the spent dialysis fluid flowing through the discharge, wherein the measuring device has at least one radiation source and a detector system for detection of the intensity of the electromagnetic radiation. Therein provided are a memory, wherein a formula A Blood = ( A Dialysate · Q Dialysate Q Blood ) is stored for the absorption ABlood, and an arithmetic unit for estimation of the absorption ABlood in the blood inflow conduit respectively the blood outflow conduit using the absorption ADialysate, the flow QDialysate, and the flow QBlood.

摘要翻译： 本发明涉及一种用透析器体外处理血液的装置，该透析器由半透膜分隔成第一和第二腔室，其中第一腔室设置在透析液通路中，第二腔室可连接血液 通过血液流入管道和血液流出管道，新鲜透析液体的进料，废透析液的排出物，用于分别估计血液流出管道中的血流QBlood的装置， 用于确定透析流体通路中的流动QDialysate的装置，以及设置在所述放电中用于估计流过所述放电的废透析液的吸收剂量的测量装置，其中所述测量装置具有至少一个辐射源和检测器 用于检测电磁辐射强度的系统。 其中提供了一种存储器，其中存储用于吸收ABlood的公式A Blood =（A透析液·Q透析液Q血液）和用于估计血液流入导管中的吸收ABlood的运算单元， 吸收ADDIysate，流量QDialysate和流量QBlood。

公开(公告)号：US08702979B2

公开(公告)日：2014-04-22

申请号：US12665150

申请日：2008-06-20

申请人： Alex Castellarnau

发明人： Alex Castellarnau

IPC分类号： B01D35/00 ,  B01D35/14

CPC分类号： A61M1/16 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/1694 ,  A61M1/3406 ,  A61M1/361 ,  A61M1/3612 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3313 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2230/20

摘要： A method for determining online adequacy parameters for any hemodialysis, hemofiltration and hemodiafiltration treatment modality is provided. Blood equilibrated dialysate samples at the begin and/or at the end of the treatment; and a continuous measurements of waste compounds in the effluent dialysate by means of spectroscopic techniques, are required. With the data coming from the measurements and a simple mathematic approach Kt/V and reduction ratios for different compounds, which are important from the medical point of view, are obtained.

摘要翻译： 提供了一种用于确定任何血液透析，血液滤过和血液透析滤过治疗方式的在线充足参数的方法。 在治疗开始和/或结束时血液平衡透析液样品; 并且需要通过光谱技术连续测量流出物透析液中的废物化合物。 利用来自测量的数据和简单的数学方法Kt / V以及从医学观点来看是重要的不同化合物的还原率。

公开(公告)号：US20130153474A1

公开(公告)日：2013-06-20

申请号：US13702846

申请日：2011-06-10

申请人： Aleksandr Frorip ,  Christoph Nacke ,  Stefan Moll ,  Alex Castellarnau ,  Joern Meibaum

发明人： Aleksandr Frorip ,  Christoph Nacke ,  Stefan Moll ,  Alex Castellarnau ,  Joern Meibaum

IPC分类号： A61M1/16

CPC分类号： A61M1/1692 ,  A61M1/16 ,  A61M1/1609 ,  A61M2205/3306 ,  A61M2205/50

摘要： The invention relates to an apparatus for extracorporeal blood treatment having a dialyzer which is divided into a first and a second chamber 29, 30 by means of a semipermeable membrane wherein the first chamber 29 is arranged in a dialysate path and the second chamber 30 can be connected to a patient's blood circulation by means of a blood supply line 32 and a blood discharge line 31, an inlet 20 for fresh dialysate, an outlet 36 for spent dialysate, a measuring device 37, wherein the measuring device 37 has at least one radiation source 1 for substantially monochromatic electromagnetic radiation. Thereby the measuring device 37 for determination of a luminescence of the spent dialysate flowing through the outlet 36 has at least one detector system (5) for detecting the intensity of the electromagnetic radiation generated by luminescence.

摘要翻译： 本发明涉及一种用于体外血液处理的装置，其具有透析器，其通过半透膜被分成第一和第二腔室29,30，其中第一腔室29布置在透析液路径中，第二腔室30可以是 通过血液供应管线32和血液排出管线31连接到患者的血液循环，用于新鲜透析液的入口20，用于透析液的出口36，测量装置37，其中测量装置37具有至少一个辐射 源1用于基本上单色的电磁辐射。 因此，用于确定流过出口36的用过的透析液的发光的测量装置37具有用于检测由发光产生的电磁辐射的强度的至少一个检测器系统（5）。

公开(公告)号：US20110163034A1

公开(公告)日：2011-07-07

申请号：US13063533

申请日：2009-09-15

申请人： Alex Castellarnau

发明人： Alex Castellarnau

IPC分类号： A61M1/16

CPC分类号： A61M1/16 ,  A61M1/1609 ,  A61M1/1613 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3344 ,  A61M2205/50 ,  A61M2230/65 ,  G06F19/00

摘要： A method for determining or predicting the adequacy parameters that will be achieved at the end of a kidney substitution treatment during said kidney substitution treatment wherein the kidney substitution treatment is provided by a machine, which has an extracorporeal blood system pumping the patient blood through the blood chamber of a dialyzer, wherein the dialyzing fluid collects the waste products from the patient after flowing through the dialyzing fluid chamber of the dialyzer and wherein a device able to measure a adequacy parameter is coupled with the kidney substitution treatment machine and wherein the slope of a preferable linear guideline for the adequacy parameter is compared to the slope of the delivered adequacy parameter and if the slope of both are equal a linearization is performed to determine or predict the adequacy parameter at the end of the kidney substitution treatment.

摘要翻译： 一种用于确定或预测在所述肾脏替代治疗期间在肾脏替代治疗结束时将实现的充分性参数的方法，其中肾脏替代治疗由机器提供，该机器具有将患者血液泵送通过血液的体外血液系统 透析器的腔室，其中所述透析流体在流过透析器的透析流体室之后从患者收集废物，并且其中能够测量适当参数的装置与肾脏替代治疗机器相结合，并且其中 将适当性参数的优选线性准则与所提供的充足参数的斜率进行比较，并且如果两者的斜率相等，则执行线性化以确定或预测肾替代治疗结束时的充分性参数。

公开(公告)号：US08568595B2

公开(公告)日：2013-10-29

申请号：US13063533

申请日：2009-09-15

申请人： Alex Castellarnau

发明人： Alex Castellarnau

IPC分类号： B01D61/32 ,  B01D61/28 ,  A61M1/16

CPC分类号： A61M1/16 ,  A61M1/1609 ,  A61M1/1613 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3344 ,  A61M2205/50 ,  A61M2230/65 ,  G06F19/00

摘要： A method for determining or predicting the adequacy parameters that will be achieved at the end of a kidney substitution treatment during said kidney substitution treatment wherein the kidney substitution treatment is provided by a machine, which has an extracorporeal blood system pumping the patient blood through the blood chamber of a dialyzer, wherein the dialyzing fluid collects the waste products from the patient after flowing through the dialyzing fluid chamber of the dialyzer and wherein a device able to measure a adequacy parameter is coupled with the kidney substitution treatment machine and wherein the slope of a preferable linear guideline for the adequacy parameter is compared to the slope of the delivered adequacy parameter and if the slope of both are equal a linearization is performed to determine or predict the adequacy parameter at the end of the kidney substitution treatment.

摘要翻译： 一种用于确定或预测在所述肾脏替代治疗期间在肾脏替代治疗结束时将实现的充分性参数的方法，其中肾脏替代治疗由机器提供，该机器具有将患者血液泵送通过血液的体外血液系统 透析器的腔室，其中所述透析流体在流过透析器的透析流体室之后从患者收集废物，并且其中能够测量适当参数的装置与肾脏替代治疗机器相结合，并且其中 将适当性参数的优选线性准则与所提供的充足参数的斜率进行比较，并且如果两者的斜率相等，则执行线性化以确定或预测肾替代治疗结束时的充分性参数。

公开(公告)号：US20130237896A1

公开(公告)日：2013-09-12

申请号：US13816968

申请日：2011-08-17

申请人： Joern Meibaum ,  Stefan Moll ,  Alex Castellarnau

发明人： Joern Meibaum ,  Stefan Moll ,  Alex Castellarnau

IPC分类号： A61M1/14

CPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/361 ,  A61M1/3612 ,  A61M2202/0498 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/52 ,  G01N21/33

摘要： The invention describes an apparatus for extracorporeal blood treatment with a dialyzer which is separated by a semipermeable membrane in to a first and second chamber (29, 30), wherein the first chamber (29) is arrange in a dialysate pathway and the second chamber (30) is connectable to the blood circulation of a patient by means of a blood supply conduit (32) and a blood return conduit (31), an inlet (20) for fresh dialysate, an outlet (30) for spent dialysate, a measuring device (37) arranged in the outlet (36), wherein said measuring device (37) has at least one radiation source consisting of several light sources (1) for electromagnetic radiation. The invention is characterized in that the measuring device (37) is designed to generate substantially monochromatic electromagnetic radiation of different wavelengths, and to lead only one of these wavelength (at the same time) though the outlet (36) for spent dialysate, wherein at least one detector system (5) is provided for detection of the intensity or the absorption of the substantially monochromatic electromagnetic radiation passing through the outlet (36) for spent dialysate.

摘要翻译： 本发明描述了一种用透析器进行体外血液处理的装置，其由半透膜分隔到第一和第二腔室（29,30）中，其中第一腔室（29）布置在透析液通路中，第二腔室 30）可通过血液供应管道（32）和血液回流管道（31），用于新鲜透析液的入口（20），用于透析液的出口（30），血液透析液 设置在所述出口（36）中的装置（37），其中所述测量装置（37）具有由用于电磁辐射的多个光源（1）组成的至少一个辐射源。 本发明的特征在于，测量装置（37）被设计成产生不同波长的基本上单色的电磁辐射，并且仅通过用于废透析液的出口（36）仅引导这些波长（同时）中的一个波长（其中在 提供了至少一个检测器系统（5），用于检测通过用于透析液的出口（36）的基本上单色的电磁辐射的强度或吸收。

公开(公告)号：US20120228226A1

公开(公告)日：2012-09-13

申请号：US13394024

申请日：2010-09-06

申请人： Alex Castellarnau ,  Jörn Ahrens ,  Stefan Moll

发明人： Alex Castellarnau ,  Jörn Ahrens ,  Stefan Moll

IPC分类号： A61M1/16 ,  B01D61/34

CPC分类号： A61M1/16 ,  A61M1/1605 ,  A61M1/3406 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3313 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/65

摘要： The invention relates to a method for normalizing, storing and/or displaying curves describing the adequacy of a kidney substitution treatment wherein the treatment is provided by a machine which has an extracorporeal blood system (31, 32) pumping the patient's blood at a preset flow rate through the blood chamber (30) of a dialyzer which is divided by a semi-permeable membrane into the blood chamber (30) and a dialyzing fluid chamber (29), and wherein the dialyzing fluid flows at a preset flow rate through the dialyzing fluid system (20, 36) of the machine and collects the waste products from the patient, and wherein a device (37) capable of continuously measuring any treatment related waste product is provided to deliver together with the data provided by the treatment machine an adequacy parameter, wherein curves describing the adequacy of the treatment are normalized to make them comparable, and/or stored in an adequate media and/or displayed on the user interface of the machine and wherein means are available to calculate parameters quantifying the adequacy differences between treatments.

摘要翻译： 本发明涉及一种用于归一化，存储和/或显示描述肾脏替代治疗的适当性的曲线的方法，其中所述治疗由具有体外血液系统（31,32）的机器提供，所述体外泵送患者的血液以预设的流量 通过透析器的血液室（30）通过半透膜分成血液室（30）和透析液室（29），并且其中透析液以预设的流速通过透析 流体系统（20,36），并且收集来自患者的废物，并且其中可以连续测量任何处理相关的废物的装置（37）与处理机提供的数据一起提供足够的 参数，其中描述治疗的适当性的曲线被归一化以使其相当，和/或存储在适当的介质中和/或显示在机器的用户界面上 d其中手段可用于计算量化治疗之间充分性差异的参数。

公开(公告)号：US20100213127A1

公开(公告)日：2010-08-26

申请号：US12665150

申请日：2008-06-20

申请人： Alex Castellarnau

发明人： Alex Castellarnau

IPC分类号： B01D61/34

CPC分类号： A61M1/16 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/1694 ,  A61M1/3406 ,  A61M1/361 ,  A61M1/3612 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3313 ,  A61M2205/3334 ,  A61M2205/50 ,  A61M2230/20

摘要： A method for determining online adequacy parameters for any hemodialysis, hemofiltration and hemodiafiltration treatment modality is provided. Blood equilibrated dialysate samples at the begin and/or at the end of the treatment; and a continuous measurements of waste compounds in the effluent dialysate by means of spectroscopic techniques, are required. With the data coming from the measurements and a simple mathematic approach Kt/V and reduction ratios for different compounds, which are important from the medical point of view, are obtained.

摘要翻译： 提供了一种用于确定任何血液透析，血液滤过和血液透析滤过治疗方式的在线充足参数的方法。 在治疗开始和/或结束时血液平衡透析液样品; 并且需要通过光谱技术连续测量流出物透析液中的废物化合物。 利用来自测量的数据和简单的数学方法Kt / V以及从医学观点来看是重要的不同化合物的还原率。