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    DIALYSIS MACHINE
    2.
    发明申请
    DIALYSIS MACHINE 审中-公开

    公开(公告)号：US20170361010A1

    公开(公告)日：2017-12-21

    申请号：US15534380

    申请日：2015-12-02

    申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

    发明人： Ralf WOJKE ,  Paul WIENEKE

    IPC分类号： A61M1/36 ,  A61M1/16 ,  A61M1/34

    CPC分类号： A61M1/361 ,  A61M1/16 ,  A61M1/1603 ,  A61M1/1613 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3413 ,  A61M1/342 ,  A61M1/36 ,  A61M1/3612 ,  A61M1/3644 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3341 ,  A61M2205/52 ,  A61M2205/70 ,  A61M2206/10 ,  A61M2206/11 ,  A61M2230/207

    摘要： The present invention relates to a dialysis machine having an extracorporeal circuit in which a dialyzer is located which has a chamber on the blood side which is flowed through by blood and a first pressure sensor, which is located upstream of the chamber on the blood side in the direction of flow of the blood, for determining a first pressure value and a second pressure sensor, which is located downstream of the chamber on the blood side in the direction of flow of the blood, for determining a second pressure value, wherein the dialysis machine has first means for determining the pressure difference between the second pressure value and the first pressure value, second means for determining the dynamic viscosity of the blood on the basis of the determined pressure difference, of the blood flow rate through the chamber on the blood side and of one or more characteristic properties of the dialyzer and third means for determining the hematocrit or the hemoglobin value of the blood on the basis of the determined viscosity, and wherein the dialysis machine has a control or regulation unit which is configured such that it sets the blood flow rate and/or the dilution rate and/or the ultrafiltration rate such that the time change of the hematocrit and/or of the hemoglobin value does not exceed a limit value or lies in a desired value range.

    Regional citrate anticoagulation
    6.
    发明授权
    Regional citrate anticoagulation 有权
    区域柠檬酸抗凝

    公开(公告)号：US09039647B2

    公开(公告)日：2015-05-26

    申请号：US13174217

    申请日：2011-06-30

    申请人： Jean-Michel Lannoy

    发明人： Jean-Michel Lannoy

    IPC分类号： A61M37/00 ,  A61M1/36 ,  A61M1/16

    CPC分类号： A61M1/3672 ,  A61M1/16 ,  A61M1/341 ,  A61M1/3607 ,  A61M1/3609 ,  A61M1/3612 ,  A61M1/3675 ,  A61M2205/15 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  A61M2205/50 ,  A61M2205/502

    摘要： A system or method automates and optimizes citrate anticoagulant supplementation in a blood filtration circuit during CRRT. A processor-based control system interfaces with a blood filtration circuit to detect patient blood flow into the circuit, detect fluid loss through a hemofilter, and sense vital electrolyte concentrations in the blood flow, and in response, control the addition of citrate, substitution fluid, and electrolyte supplements to ensure stability of plasma concentrations in post-dilution flow returned to the patient. The controller executes the method embodied as process control algorithms for calculating an optimal citrate flow rate as a function of selected, detected, and calculated system parameters. Citrate may be added to the circuit separately, or as part of a substitution solution or a dialysate.

    摘要翻译： 一种系统或方法在CRRT期间自动化和优化血液过滤电路中的柠檬酸抗凝剂补充。 基于处理器的控制系统与血液过滤电路接口以检测患者血液进入电路，通过血液滤过器检测流体损失，并感测血流中的重要电解质浓度，并且作为响应，控制柠檬酸盐，置换液体的添加 ，和电解质补充剂，以确保返回给病人的后稀释流中血浆浓度的稳定性。 控制器执行作为过程控制算法体现的方法，用于根据所选择的，检测的和计算的系统参数来计算最佳柠檬酸盐流速。 柠檬酸盐可以分别添加到电路中，也可以作为替代溶液或透析液的一部分。

    PROCESS AND DEVICE FOR MONITORING THE SUPPLY OF SUBSTITUTION FLUID DURING AN EXTRACORPOREAL TREATMENT OF BLOOD
    8.
    发明申请
    PROCESS AND DEVICE FOR MONITORING THE SUPPLY OF SUBSTITUTION FLUID DURING AN EXTRACORPOREAL TREATMENT OF BLOOD 审中-公开
    用于监测血液提取液中替代液的供应的过程和装置

    公开(公告)号：US20140246373A1

    公开(公告)日：2014-09-04

    申请号：US14273787

    申请日：2014-05-09

    申请人： Fresenius Medical Care Deutschland GmbH

    发明人： Pascal Kopperschmidt

    IPC分类号： A61M1/16

    CPC分类号： A61M1/342 ,  A61B5/02141 ,  A61B5/7225 ,  A61B5/7257 ,  A61M1/1601 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3465 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3639 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3658 ,  A61M2205/3355 ,  A61M2205/702 ,  A61M2230/30

    摘要： The invention relates to a process for monitoring the supply of substitution fluid upstream or downstream of a dialyser or filter arranged in an extracorporeal blood stream. One embodiment provides, for the detection of predilution or postdilution, for measuring the pressure in the blood stream downstream of the dialyser or filter, predilution or postdilution being recognized on the basis of the change in pressure following the shutting off and/or starting up of the substituate pump provided for conveying the substitution fluid. Another embodiment provides for recognizing predilution or postdilution on the basis of the comparison of the oscillating pressure signal attributable to the substituate pump to a characteristic reference signal. The characteristic reference signal to which the pressure signal of the substituate pump is compared is preferably the oscillating pressure signal of a blood pump arranged in the blood stream for conveying the blood upstream of the dialyser or filter. In addition, the invention relates to an extracorporeal blood treatment device with a facility for detecting predilution or postdilution, which device operates according to the processes detailed above.

    摘要翻译： 本发明涉及一种用于监测布置在体外血流中的透析器或过滤器上游或下游的置换液的供给的方法。 一个实施方案提供了用于检测预稀释或后稀释用于测量透析器或过滤器下游的血流中的压力，根据在关闭和/或启动后的压力变化来识别预稀释或后稀释 提供用于输送替代流体的替代泵。 另一个实施例提供了基于归因于替代泵的振荡压力信号与特征参考信号的比较来识别预稀释或后稀释。 比较替代泵的压力信号的特征参考信号优选是布置在用于输送透析器或过滤器上游的血液的血液中的血液泵的振荡压力信号。 此外，本发明涉及具有检测预稀释或后稀释的设备的体外血液处理装置，该装置根据上述方法进行操作。

    METHOD FOR ULTRAFILTRATION OF BLOOD
    9.
    发明申请
    METHOD FOR ULTRAFILTRATION OF BLOOD 有权
    血液超滤的方法

    公开(公告)号：US20140231350A1

    公开(公告)日：2014-08-21

    申请号：US14100167

    申请日：2013-12-09

    申请人： Gambro UF Solutions, Inc.

    发明人： Howard Levin ,  Mark Gelfand ,  John O'Mahony ,  Hans-Dietrich Polaschegg

    IPC分类号： A61M1/34

    CPC分类号： A61M1/341 ,  A61M1/1692 ,  A61M1/34 ,  A61M1/361 ,  A61M1/3612 ,  A61M2205/3393 ,  A61M2205/50 ,  A61M2205/7563

    摘要： A method for filtering blood including: withdrawing blood from an adult patient; performing ultrafiltration by filtering the withdrawn blood in a filter having an active filter membrane surface of no greater than 0.2 meters squared (m2) to remove ultrafiltrate from the blood, wherein the filter membrane blocks the passage of blood molecules having a molecular weight of at least 60,000 Daltons, wherein an amount of the removed ultrafiltrate is an effective therapeutic amount for treating a fluid overload condition of the patient; infusing the ultrafiltrated blood into the adult patient, and pumping the ultrafiltrate from the filter a rate no greater than one liter per hour.

    摘要翻译： 一种过滤血液的方法，包括：从成年患者抽出血液; 通过在具有不大于0.2m 2（m 2）的活性过滤膜表面的过滤器中过滤取出的血液以从血液中除去超滤液来进行超滤，其中过滤膜阻止至少具有分子量的血液分子的通过 60,000道尔顿，其中所述去除的超滤液的量是治疗患者的流体过载状况的有效治疗量; 将超滤的血液注入成年患者，并将超滤液从过滤器中抽出不超过1升/小时。

    APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT
    10.
    发明申请
    APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT 有权
    用于提取血液治疗的装置

    公开(公告)号：US20130237896A1

    公开(公告)日：2013-09-12

    申请号：US13816968

    申请日：2011-08-17

    申请人： Joern Meibaum ,  Stefan Moll ,  Alex Castellarnau

    发明人： Joern Meibaum ,  Stefan Moll ,  Alex Castellarnau

    IPC分类号： A61M1/14

    CPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/1609 ,  A61M1/1613 ,  A61M1/361 ,  A61M1/3612 ,  A61M2202/0498 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/52 ,  G01N21/33

    摘要： The invention describes an apparatus for extracorporeal blood treatment with a dialyzer which is separated by a semipermeable membrane in to a first and second chamber (29, 30), wherein the first chamber (29) is arrange in a dialysate pathway and the second chamber (30) is connectable to the blood circulation of a patient by means of a blood supply conduit (32) and a blood return conduit (31), an inlet (20) for fresh dialysate, an outlet (30) for spent dialysate, a measuring device (37) arranged in the outlet (36), wherein said measuring device (37) has at least one radiation source consisting of several light sources (1) for electromagnetic radiation. The invention is characterized in that the measuring device (37) is designed to generate substantially monochromatic electromagnetic radiation of different wavelengths, and to lead only one of these wavelength (at the same time) though the outlet (36) for spent dialysate, wherein at least one detector system (5) is provided for detection of the intensity or the absorption of the substantially monochromatic electromagnetic radiation passing through the outlet (36) for spent dialysate.

    摘要翻译： 本发明描述了一种用透析器进行体外血液处理的装置，其由半透膜分隔到第一和第二腔室（29,30）中，其中第一腔室（29）布置在透析液通路中，第二腔室 30）可通过血液供应管道（32）和血液回流管道（31），用于新鲜透析液的入口（20），用于透析液的出口（30），血液透析液 设置在所述出口（36）中的装置（37），其中所述测量装置（37）具有由用于电磁辐射的多个光源（1）组成的至少一个辐射源。 本发明的特征在于，测量装置（37）被设计成产生不同波长的基本上单色的电磁辐射，并且仅通过用于废透析液的出口（36）仅引导这些波长（同时）中的一个波长（其中在 提供了至少一个检测器系统（5），用于检测通过用于透析液的出口（36）的基本上单色的电磁辐射的强度或吸收。