公开(公告)号：US5536719A

公开(公告)日：1996-07-16

申请号：US500609

申请日：1995-07-11

申请人： Alex Cordi ,  Michael Spedding ,  Bernard Serkiz ,  Jean Lepagnol ,  Patrice Desos ,  Philippe Morain

发明人： Alex Cordi ,  Michael Spedding ,  Bernard Serkiz ,  Jean Lepagnol ,  Patrice Desos ,  Philippe Morain

IPC分类号： A61K31/54 ,  A61K31/549 ,  A61P25/00 ,  A61P25/18 ,  A61P25/20 ,  A61P25/28 ,  A61P43/00 ,  C07B53/00 ,  C07B57/00 ,  C07B61/00 ,  C07D513/04

CPC分类号： C07D513/04

摘要： A compound of formula (I): ##STR1## in the form of its S enantiomer, its addition salts with a pharmaceutically acceptable acid or base and medicinal product containing the same are useful for the treatment or prevention of pathologies associated with dysfunction of glutamatergic neurotransmission.

摘要翻译： 式（I）化合物：其S对映异构体形式的其（I）化合物，其与药学上可接受的酸或碱的加成盐和含有其的药物可用于治疗或预防与功能障碍相关的病理学 谷氨酸能神经传递。

公开(公告)号：US5776949A

公开(公告)日：1998-07-07

申请号：US889920

申请日：1997-07-10

申请人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol ,  Philippe Morain ,  Pierre Lestage

发明人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol ,  Philippe Morain ,  Pierre Lestage

IPC分类号： A61K31/47 ,  A61P9/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07D215/36 ,  C07D401/04 ,  C07D471/04 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D215/36 ,  C07D233/56 ,  C07D249/08 ,  C07D401/04 ,  C07D471/04

摘要： A compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, which are identical or different, represent hydrogen, halogen, alkyl, nitro, cyano, aminosulfonyl, imidazolyl, or pyrrolyl, or alternatively, when two of them are situated on adjacent carbons, may form with the carbon atoms to which they are attached a benzene ring on C.sub.3 -C.sub.7 cyloalkyl R.sub.4 represents hydroxyl, alkoxy, phenoxy, or amino, their isomers as well as their addition salts with a pharmaceutically-acceptable base, and medicinal products containing the same which are useful as inhibitors of the the pathological phenomena linked to hyperactivation of the neurotransmission pathways by the excitatory amino acids.

摘要翻译： 式（I）化合物：其中：R 1，R 2，R 3相同或不同，表示氢，卤素，烷基，硝基，氰基，氨基磺酰基，咪唑基或吡咯基，或者， 当它们中的两个位于相邻的碳上时，可以与它们所连接的碳原子一起形成C3-C7环烷基上的苯环R4表示羟基，烷氧基，苯氧基或氨基，它们的异构体以及它们与 药学上可接受的碱和含有它们的药物，其可用作与兴奋性氨基酸对神经传递途径的过度活化有关的病理现象的抑制剂。

公开(公告)号：US5646132A

公开(公告)日：1997-07-08

申请号：US499946

申请日：1995-07-10

申请人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol

发明人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol

IPC分类号： A61K31/675 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07F9/576 ,  C07F9/60

CPC分类号： C07F9/5765 ,  C07F9/60

摘要： Compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3, which are identical or different, represent hydrogen or halogen or alkyl, nitro, cyano or aminosulfonyl, or alternatively, when two of them are located on adjacent carbons, form, with the carbon atoms to which they are attached, (C.sub.3 -C.sub.7) cycloalkyl ring or substituted or unsubstituted benzene ring,R.sub.4 represents hydrogen, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or a group ##STR2## in which R.sub.6 and R.sub.7, which are identical or different, represent hydrogen or substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl,R.sub.5 represents hydrogen, hydroxyl, linear or branched (C.sub.1 -C.sub.6) alkoxy, phenoxy, mercapto, linear or branched (C.sub.1 -C.sub.6) alkylthio, substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or substituted or unsubstituted amino, or a group ##STR3## in which R.sub.6 and R.sub.7 are as defined above, their isomers as well as their addition salts with a pharmaceutically acceptable acid or base, and medicinal product containing the same are useful as inhibitor of the pathological phenomena associated with hyperactivation of the excitating amino acid-dependant pathways of neurotransmission.

摘要翻译： 式（I）化合物：其中：R 1，R 2和R 3相同或不同，表示氢或卤素或烷基，硝基，氰基或氨基磺酰基，或者当其中两个位于 （C 3 -C 7）环烷基环或取代或未取代的苯环，R 4表示氢，直链或支链（C 1 -C 6）烷基，取代或未取代的苯基或取代或未取代的苯基 基团其中R6和R7相同或不同，表示氢或取代或未取代的直链或支链（C1-C6）烷基，R5表示氢，羟基，直链或支链（C1-C6）烷氧基，苯氧基 （C1-C6）烷基，取代或未取代的直链或支链（C1-C6）烷基，取代或未取代的苯基或取代或未取代的氨基，或其中R6和R7为 它们的异构体以及它们与药物的加成盐 可接受的酸或碱，以及含有它们的药物可用作与神经传递的兴奋性氨基酸依赖性途径的高活化相关的病理现象的抑制剂。

公开(公告)号：US5536709A

公开(公告)日：1996-07-16

申请号：US297793

申请日：1994-08-30

申请人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol

发明人： Alex Cordi ,  Patrice Desos ,  Jean Lepagnol

IPC分类号： A61K31/675 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61P43/00 ,  C07F9/576 ,  C07F9/60 ,  C07D215/227 ,  C07F9/38

CPC分类号： C07F9/5765 ,  C07F9/60

摘要： Compound of formula (I): ##STR1## in which R.sub.1, R.sub.2 and R.sub.3, which are identical or different, represent hydrogen or halogen or alkyl, nitro, cyano or aminosulfonyl, or alternatively, when two of them are located on adjacent carbons, form, with the carbon atoms to which they are attached, (C.sub.3 -C.sub.7) cycloalkyl ring or substituted or unsubstituted benzene ring,R.sub.4 represents hydrogen, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or a group ##STR2## in which R.sub.6 and R.sub.7, which are identical or different, represent hydrogen or substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl,R.sub.5 represents hydrogen, hydroxyl, linear or branched (C.sub.1 -C.sub.6) alkoxy, phenoxy, mercapto, linear or branched (C.sub.1 -C.sub.6) alkylthio, substituted or unsubstituted, linear or branched (C.sub.1 -.sub.6) alkyl, substituted or unsubstituted phenyl or substituted or unsubstituted amino; or a group ##STR3## in which R.sub.6 and R.sub.7 are as defined above, their isomers as well as their addition salts with a pharmaceutically acceptable acid or base, and medicinal product containing the same are useful as inhibitor of the pathological phenomena associated with hyperactivation of the excitating amino acid-dependant pathways of neurotransmission.

摘要翻译： 式（I）化合物：其中R 1，R 2和R 3相同或不同，表示氢或卤素或烷基，硝基，氰基或氨基磺酰基，或者当它们中的两个位于 （C 3 -C 7）环烷基环或取代或未取代的苯环，R 4表示氢，直链或支链（C 1 -C 6）烷基，取代或未取代的苯基或基团 其中R6和R7相同或不同，表示氢或取代或未取代的直链或支链（C1-C6）烷基，R5代表氢，羟基，直链或支链（C1-C6）烷氧基，苯氧基， 直链或支链（C1-C6）烷硫基，取代或未取代的直链或支链（C1-6）烷基，取代或未取代的苯基或取代或未取代的氨基; 或其中R 6和R 7如上所定义的基团，其异构体及其与药学上可接受的酸或碱的加成盐，以及含有它们的药物可用作与超活化相关的病理现象的抑制剂 兴奋性氨基酸依赖的神经传递途径。

公开(公告)号：US06486143B2

公开(公告)日：2002-11-26

申请号：US09784632

申请日：2001-02-15

申请人： Alex Cordi ,  Patrice Desos ,  Pierre Lestage

发明人： Alex Cordi ,  Patrice Desos ,  Pierre Lestage

IPC分类号： A61K31675

CPC分类号： C07F9/60

摘要： The invention relates to a compound of formula (I): wherein: R1 represents halogen or a group CF3, R2 represents hydrogen or alkyl or cycloalkyl, R3 is as defined in the description, R4 and R5 represent hydrogen or alkyl, cycloalkyl, aryl or arylalkyl a group Medicaments.

摘要翻译： 本发明涉及式（I）化合物：其中：R 1表示卤素或基团CF 3，R 2表示氢或烷基或环烷基，R 3如说明书中所定义，R 4和R 5表示氢或烷基，环烷基，芳基或 芳基烷基一个基团。

公开(公告)号：US5670493A

公开(公告)日：1997-09-23

申请号：US684469

申请日：1996-07-19

申请人： Alex Cordi ,  Patrice Desos ,  Angela D. Morris ,  Ghanem Atassi

发明人： Alex Cordi ,  Patrice Desos ,  Angela D. Morris ,  Ghanem Atassi

IPC分类号： A61K31/66 ,  A61K31/665 ,  A61K31/67 ,  A61K31/675 ,  A61P27/02 ,  A61P35/00 ,  C07F9/38 ,  C07F9/40 ,  C07F9/572 ,  C07F9/655 ,  C07F9/6553

CPC分类号： C07F9/655345 ,  C07F9/3834 ,  C07F9/3882 ,  C07F9/4021 ,  C07F9/5728 ,  C07F9/65515

摘要： A compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2, which may be identical or different, represent hydrogen or halogen, or alkyl, alkoxy, nitro or trihalomethyl, X represents CO, SO.sub.2 or CH.sub.2, A.sub.1 represents any one of the groups as defined in the description, A.sub.2 represents --(CH.sub.2).sub.n or --CH.dbd.CH--, R.sub.3, R.sub.4, which may be identical or different, represent hydrogen or alkyl, its isomers as well as its addition salts with a pharmaceutically acceptable base and medicinal product containing the same are useful as angiogenesis inhibitors.

摘要翻译： 式（I）化合物：其中：R 1，R 2可以相同或不同，表示氢或卤素，或烷基，烷氧基，硝基或三卤甲基，X表示CO，SO 2或CH 2， A1表示说明书中定义的任何一个基团，A 2表示 - （CH 2）n或-CH = CH-，R 3，R 4可以相同或不同，表示氢或烷基，其异构体及其加成 与药学上可接受的碱的盐和含有它们的药物可用作血管发生抑制剂。

公开(公告)号：US07423034B2

公开(公告)日：2008-09-09

申请号：US11823439

申请日：2007-06-27

申请人： Patrice Desos ,  Alex Cordi ,  Pierre Lestage

发明人： Patrice Desos ,  Alex Cordi ,  Pierre Lestage

IPC分类号： C07D285/22 ,  A61K31/5415 ,  A61P25/24

CPC分类号： C07D513/04

摘要： Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or hydroxy, A represents NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, X is as defined in the description, their isomers, and also addition salts thereof. Medicinal products containing the same which are useful in treating disorders of the AMPA system.

摘要翻译： 式（I）的化合物：其中：R 1表示氢，卤素或烷基，R 1a表示氢或烷基，R 2表示 氢，卤素或羟基，A表示NR 4，R 3表示氢，烷基或环烷基，R 4表示氢或烷基，X 如说明书中所定义，它们的异构体及其加成盐。 含有该药物的药物可用于治疗AMPA系统的病症。

公开(公告)号：US20070249594A1

公开(公告)日：2007-10-25

申请号：US11823439

申请日：2007-06-27

申请人： Patrice Desos ,  Alex Cordi ,  Pierre Lestage

发明人： Patrice Desos ,  Alex Cordi ,  Pierre Lestage

IPC分类号： A61K31/549 ,  A61K31/554 ,  C07D279/16 ,  C07D285/22

CPC分类号： C07D513/04

摘要： Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or hydroxy, A represents NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, X is as defined in the description, their isomers, and also addition salts thereof. Medicinal products containing the same which are useful in treating disorders of the AMPA system.

摘要翻译： 式（I）的化合物：其中：R 1表示氢，卤素或烷基，R 1a表示氢或烷基，R 2表示 氢，卤素或羟基，A表示NR 4，R 3表示氢，烷基或环烷基，R 4表示氢或烷基，X 如说明书中所定义，它们的异构体及其加成盐。 含有该药物的药物可用于治疗AMPA系统的病症。

公开(公告)号：US07250411B2

公开(公告)日：2007-07-31

申请号：US10499082

申请日：2002-12-20

申请人： Alex Cordi ,  Patrice Desos ,  Pierre Lestage

发明人： Alex Cordi ,  Patrice Desos ,  Pierre Lestage

IPC分类号： C07D285/22 ,  A61K31/5415 ,  A61P25/24

CPC分类号： C07D285/24 ,  C07D279/02

摘要： Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, R3 represents hydrogen, linear or branched (C1-C6)alkyl or (C3-C7)cycloalkyl, A represents CR4R5 or NR4, R4 represents hydrogen or linear or branched (C1-C6)alkyl,their isomers and also their addition salts with a pharmaceutically acceptable acid or base.Medicaments.

摘要翻译： 式（I）化合物：其中：R 1表示羟基或RCO-O-，R 2表示氢，卤素，羟基或R'CO-O，R， R'可以相同或不同，表示直链或支链（C 1 -C 6 -C 6）烷基，其任选被直链或支链的芳基（C 2 任选被芳基，直链或支链（C 1 -C 6 -C 6）全卤代烷基取代的（C 1 -C 6 - 金刚烷基，芳基或杂芳基，R 3表示直链或支链（C 1 -C 3）烷基的氢， C 1 -C 6烷基或（C 3 -C 7 -C 7）环烷基，A表示CR 4 R 7， R 5或NR 4，R 4表示氢或直链或支链（C 1 -C 6 - /它们的异构体，以及它们与药学上可接受的酸或碱的加成盐。 药剂

公开(公告)号：US20050014744A1

公开(公告)日：2005-01-20

申请号：US10499082

申请日：2002-12-20

申请人： Alex Cordi ,  Patrice Desos ,  Pierre Lestage

发明人： Alex Cordi ,  Patrice Desos ,  Pierre Lestage

IPC分类号： A61K31/5415 ,  A61K31/549 ,  A61P9/10 ,  A61P25/08 ,  A61P25/14 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07B61/00 ,  C07D279/02 ,  C07D285/24 ,  C07D279/16 ,  C07D285/22

CPC分类号： C07D285/24 ,  C07D279/02

摘要： Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, R3 represents hydrogen, linear or branched (C1-C6)alkyl or (C3-C7)cycloalkyl, A represents CR4R5 or NR4, R4 represents hydrogen or linear or branched (C1-C6)alkyl, their isomers and also their addition salts with a pharmaceutically acceptable acid or base. Medicaments.

摘要翻译： 式（I）化合物：其中：R 1表示羟基或RCO-O-，R 2表示氢，卤素，羟基或R'CO-O，R，R'可以相同或不同，表示直链或支链 任选被芳基，直链或支链（C1-C6）全卤代烷基，（C3-C7）环烷基，金刚烷基，芳基或杂芳基取代的直链或支链（C2-C6）烯基取代的-C6-烷基，R3代表氢， 直链或支链（C1-C6）烷基或（C3-C7）环烷基，A表示CR4R5或NR4，R4表示氢或直链或支链（C1-C6）烷基，它们的异构体，以及它们与药学上可接受的酸的加成盐或 基础。 药剂