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公开(公告)号：US5637756A
公开(公告)日：1997-06-10
申请号：US444275
申请日：1995-05-18
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/14 , A61K8/33 , A61K8/365 , A61K8/37 , A61K8/42 , A61K8/49 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C69/732 , C07C69/734 , C07C69/86 , C07C69/92 , C07C235/34 , C07C69/76
CPC分类号： C07C69/732 , A61K8/365 , A61K8/37 , A61K8/375 , A61K8/42 , A61Q17/04 , A61Q19/02 , Y10S514/844 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/943 , Y10S514/944 , Y10S977/926
摘要： A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, OH, or ##STR2## R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups; r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle;the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21;R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy; R.sub.4 represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.4 alkyl radical; andn is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.
摘要翻译： 具有脱色作用的化妆品或皮肤病学组合物包括2,5-二羟基苯基羧酸的衍生物，它们的同系物及其盐，其衍生物具有以下结构式：其中：R1表示OR5，OH或 R 5是直链或支链C 1 -C 20烷基，直链或支链C 2 -C 20烯基或被一个或多个羟基或烷氧基取代的C 1 -C 20烷基; r'和r“相同或不同，表示氢原子，C1-C20烷基，C2-C6羟基烷基或C3-C6多羟基烷基，或r'和r”与氮 原子，形成杂环; - （CH2）n-COR1链中的碳原子数小于或等于21; R2和R3相同或不同，表示氢原子，直链或支链C 1 -C 4烷基或C 1 -C 4烷氧基; R4表示氢原子或直链或支链C1-C4烷基; 并且n为0至20的整数，条件是当R 2和R 3表示氢原子时，n大于或等于2。
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2.发明授权Utilization of derivatives of 2,5 dihydroxyphenyl-carboxylic acid amides and their salts in preparation of a cosmetic or dermatological composition with a depigmenting action 失效在制备具有脱色作用的化妆品或皮肤病学组合物中使用2,5二羟基苯基 - 羧酸酰胺及其盐的衍生物
公开(公告)号：US5587173A
公开(公告)日：1996-12-24
申请号：US465105
申请日：1995-06-05
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/14 , A61K8/33 , A61K8/365 , A61K8/37 , A61K8/42 , A61K8/49 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C69/732 , C07C69/734 , C07C69/86 , C07C69/92 , C07C235/34 , A61K7/42
CPC分类号： C07C69/732 , A61K8/365 , A61K8/37 , A61K8/375 , A61K8/42 , A61Q17/04 , A61Q19/02 , Y10S514/844 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/943 , Y10S514/944 , Y10S977/926
摘要： A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, OH, or ##STR2## R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups;r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle;the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21;R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy; R.sub.4 represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.4 alkyl radical; andn is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.
摘要翻译： 具有脱色作用的化妆品或皮肤病学组合物包括2,5-二羟基苯基羧酸的衍生物，它们的同系物及其盐，其衍生物具有以下结构式：其中：R1表示OR5，OH或 R 5是直链或支链C 1 -C 20烷基，直链或支链C 2 -C 20烯基或被一个或多个羟基或烷氧基取代的C 1 -C 20烷基; r'和r“相同或不同，表示氢原子，C1-C20烷基，C2-C6羟基烷基或C3-C6多羟基烷基，或r'和r”与氮 原子，形成杂环; - （CH2）n-COR1链中的碳原子数小于或等于21; R2和R3相同或不同，表示氢原子，直链或支链C 1 -C 4烷基或C 1 -C 4烷氧基; R4表示氢原子或直链或支链C1-C4烷基; 并且n为0至20的整数，条件是当R 2和R 3表示氢原子时，n大于或等于2。
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3.发明授权Utilization of derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts in preparation of a cosmetic or dermatological composition with a depigmenting action 失效在制备具有脱色作用的化妆品或皮肤病学组合物中使用2,5-二羟基苯基羧酸的衍生物，其同系物及其盐
公开(公告)号：US5585105A
公开(公告)日：1996-12-17
申请号：US444276
申请日：1995-05-18
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/14 , A61K8/33 , A61K8/365 , A61K8/37 , A61K8/42 , A61K8/49 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C69/732 , C07C69/734 , C07C69/86 , C07C69/92 , C07C235/34 , A61K7/42
CPC分类号： C07C69/732 , A61K8/365 , A61K8/37 , A61K8/375 , A61K8/42 , A61Q17/04 , A61Q19/02 , Y10S514/844 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/943 , Y10S514/944 , Y10S977/926
摘要： A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, OH, or ##STR2## R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups;r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle;the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21;R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy;R.sub.4 represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.4 alkyl radical; andn is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.
摘要翻译： 具有脱色作用的化妆品或皮肤病学组合物包括2,5-二羟基苯基羧酸的衍生物，它们的同系物及其盐，其衍生物具有以下结构式：其中：R1表示OR5，OH或 R 5是直链或支链C 1 -C 20烷基，直链或支链C 2 -C 20烯基或被一个或多个羟基或烷氧基取代的C 1 -C 20烷基; r'和r“相同或不同，表示氢原子，C1-C20烷基，C2-C6羟基烷基或C3-C6多羟基烷基，或r'和r”与氮 原子，形成杂环; - （CH2）n-COR1链中的碳原子数小于或等于21; R2和R3相同或不同，表示氢原子，直链或支链C 1 -C 4烷基或C 1 -C 4烷氧基; R4表示氢原子或直链或支链C1-C4烷基; 并且n为0至20的整数，条件是当R 2和R 3表示氢原子时，n大于或等于2。
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4.发明授权Utilization of derivatives of 2,5-dihydroxyphenyl-carboxylic acids, their homologs, and their salts in preparation of a cosmetic or dermatological composition with a depigmenting action 失效在制备具有脱色作用的化妆品或皮肤病学组合物中使用2,5-二羟基苯基 - 羧酸的衍生物，其同系物及其盐
公开(公告)号：US5449518A
公开(公告)日：1995-09-12
申请号：US913950
申请日：1992-07-17
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/14 , A61K8/33 , A61K8/365 , A61K8/37 , A61K8/42 , A61K8/49 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C69/732 , C07C69/734 , C07C69/86 , C07C69/92 , C07C235/34 , A61K7/42
CPC分类号： C07C69/732 , A61K8/365 , A61K8/37 , A61K8/375 , A61K8/42 , A61Q17/04 , A61Q19/02 , Y10S514/844 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/943 , Y10S514/944 , Y10S977/926
摘要： A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, or ##STR2## R.sub.5 is a hydrogen atom, a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups; r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle; the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21;R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy; R.sub.4 represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.4 alkyl radical; and n is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.
摘要翻译： 具有脱色作用的化妆品或皮肤病学组合物包含2,5-二羟基苯基羧酸的衍生物，它们的同系物及其盐，其衍生物具有以下结构式：其中：R 1表示OR 5或
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5.发明授权Derivatives of 2,5-dihydroxyphenylcarboxylic acids, and their utilization in cosmetic or dermatological compositions with a depigmenting action 失效2,5-二羟基苯基羧酸的衍生物及其在化妆品或皮肤病学组合物中的用途，其具有脱色作用
公开(公告)号：US5667792A
公开(公告)日：1997-09-16
申请号：US684705
申请日：1996-07-19
IPC分类号： A61K8/30 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/14 , A61K8/33 , A61K8/365 , A61K8/37 , A61K8/42 , A61K8/49 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07C69/732 , C07C69/734 , C07C69/86 , C07C69/92 , C07C235/34 , A61K7/42
CPC分类号： C07C69/732 , A61K8/365 , A61K8/37 , A61K8/375 , A61K8/42 , A61Q17/04 , A61Q19/02 , Y10S514/844 , Y10S514/846 , Y10S514/937 , Y10S514/938 , Y10S514/943 , Y10S514/944 , Y10S977/926
摘要： A cosmetic or dermatological composition with a depigmenting action comprises derivatives of 2,5-dihydroxyphenylcarboxylic acids, their homologs, and their salts, with the derivatives having the following structural formula: ##STR1## wherein: R.sub.1 represents OR.sub.5, OH, or ##STR2## R.sub.5 is a linear or branched C.sub.1 -C.sub.20 alkyl radical, a linear or branched C.sub.2 -C.sub.20 alkenyl radical, or a C.sub.1 -C.sub.20 alkyl radical substituted by one or more hydroxy or alkoxy groups;r' and r", identical or different, represent a hydrogen atom, a C.sub.1 -C.sub.20 alkyl radical, a C.sub.2 -C.sub.6 hydroxyalkyl radical, or a C.sub.3 -C.sub.6 polyhydroxyalkyl, or r' and r" taken together, with the nitrogen atom, form a heterocycle;the number of carbon atoms in the --(CH.sub.2).sub.n --COR.sub.1 chain is less than or equal to 21;R.sub.2 and R.sub.3, identical or different, represent a hydrogen atom, a linear or branched C.sub.1 -C.sub.4 alkyl radical, or a C.sub.1 -C.sub.4 alkoxy; R.sub.4 represents a hydrogen atom or a linear or branched C.sub. -C.sub.4 alkyl radical; andn is an integer from 0 to 20, provided that, when R.sub.2 and R.sub.3 represent a hydrogen atom, n is greater than or equal to 2.
摘要翻译： 具有脱色作用的化妆品或皮肤病学组合物包括2,5-二羟基苯基羧酸的衍生物，它们的同系物及其盐，其衍生物具有以下结构式：其中：R1表示OR5，OH或 R 5是直链或支链C 1 -C 20烷基，直链或支链C 2 -C 20烯基或被一个或多个羟基或烷氧基取代的C 1 -C 20烷基; r'和r“相同或不同，表示氢原子，C1-C20烷基，C2-C6羟基烷基或C3-C6多羟基烷基，或r'和r”与氮 原子，形成杂环; - （CH2）n-COR1链中的碳原子数小于或等于21; R2和R3相同或不同，表示氢原子，直链或支链C 1 -C 4烷基或C 1 -C 4烷氧基; R4表示氢原子或直链或支链C-C4烷基; 并且n为0至20的整数，条件是当R 2和R 3表示氢原子时，n大于或等于2。
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