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公开(公告)号：US20060160807A1
公开(公告)日：2006-07-20
申请号：US11312618
申请日：2005-12-20
申请人： Alexander Aronov , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Judith Straub , Qing Tang
发明人： Alexander Aronov , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Judith Straub , Qing Tang
IPC分类号： A61K31/53 , A61K31/506 , C07D413/02 , C07D403/02
CPC分类号： C07D403/04
摘要： Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
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公开(公告)号：US07501415B2
公开(公告)日：2009-03-10
申请号：US11312618
申请日：2005-12-20
申请人： Alexander Aronov , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Judith Straub , Qing Tang
发明人： Alexander Aronov , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Judith Straub , Qing Tang
IPC分类号： C07D403/04 , A61K31/506
CPC分类号： C07D403/04
摘要： Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
摘要翻译： 本文描述的是可用作ERK2抑制剂的化合物。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种病症（包括增殖性疾病如癌症）的严重性。
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3.发明授权Pyrrole inhibitors of ERK protein kinase, synthesis thereof and intermediates thereto 有权ERK蛋白激酶的吡咯抑制剂，其合成及其中间体公开(公告)号：US07354939B2
公开(公告)日：2008-04-08
申请号：US11128870
申请日：2005-05-13
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07F9/65583 , C07D401/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20060142572A1
公开(公告)日：2006-06-29
申请号：US11302295
申请日：2005-12-13
申请人： Gabriel Martinez-Botella , Alex Aronov , Michael Hale , Francois Maltais , Judith Straub , Qing Tang
发明人： Gabriel Martinez-Botella , Alex Aronov , Michael Hale , Francois Maltais , Judith Straub , Qing Tang
IPC分类号： C07D405/02 , C07D403/02
CPC分类号： C07D239/48
摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring A, Z1, Z2, U, Q, R1, R2, and L are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
摘要翻译： 本文描述了可用作式I的蛋白激酶抑制剂的化合物或其药学上可接受的盐，其中环A，Z 1，Z 2，U，Q， R 1，R 2和L如本文所定义。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种病症（包括增殖性疾病如癌症）的严重性。
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公开(公告)号：US20060058318A1
公开(公告)日：2006-03-16
申请号：US11129114
申请日：2005-05-13
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D403/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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6.发明申请Pyrrole inhibitors of ERK protein kinase, synthesis thereof and intermediates thereto 有权ERK蛋白激酶的吡咯抑制剂，其合成及其中间体公开(公告)号：US20060106069A1
公开(公告)日：2006-05-18
申请号：US11128870
申请日：2005-05-13
IPC分类号： A61K31/4439 , C07D403/04
CPC分类号： C07F9/65583 , C07D401/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07358258B2
公开(公告)日：2008-04-15
申请号：US11129114
申请日：2005-05-13
IPC分类号： C07D403/04 , A61K31/506 , A61P35/00 , A61P9/10 , A61P11/06 , A61P25/28
CPC分类号： C07D403/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20050245499A1
公开(公告)日：2005-11-03
申请号：US11001760
申请日：2004-12-02
申请人： Judith Straub , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Alex Aronov , Guy Bemis
发明人： Judith Straub , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Alex Aronov , Guy Bemis
IPC分类号： A61K31/506 , A61K45/06 , C07D239/48 , C07D251/18 , C07D401/04 , C07D403/04 , C07D405/04 , A61K31/4545 , A61K31/53 , C07D43/02
CPC分类号： C07D239/48 , A61K31/506 , A61K45/06 , C07D251/18 , C07D401/04 , C07D403/04 , C07D405/04 , A61K2300/00
摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R2, R3, and R3 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
摘要翻译： 本文描述了可用作式I的蛋白激酶抑制剂的化合物或其药学上可接受的盐，其中环B，Z 1，Z 2，U，p， Q，R 1，R 2，R 3，R 3和R 3如本文所定义。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种疾病的严重性，包括中风，炎性疾病，自身免疫性疾病如SLE狼疮和牛皮癣，增殖性疾病如癌症，以及与器官移植相关的病症 。
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公开(公告)号：US07244735B2
公开(公告)日：2007-07-17
申请号：US11001760
申请日：2004-12-02
申请人： Judith Straub , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Alex Aronov , Guy Bemis
发明人： Judith Straub , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Alex Aronov , Guy Bemis
IPC分类号： A61K31/496 , A61K31/506 , C07D239/48
CPC分类号： C07D239/48 , A61K31/506 , A61K45/06 , C07D251/18 , C07D401/04 , C07D403/04 , C07D405/04 , A61K2300/00
摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring B, Z1, Z2, U, p, Q, R1, R2, R3, and R3 are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including stroke, inflammatory disorders, autoimmune diseases such as SLE lupus and psoriasis, proliferative disorders such as cancer, and conditions associated with organ transplantation.
摘要翻译： 本文描述了可用作式I的蛋白激酶抑制剂的化合物或其药学上可接受的盐，其中环B，Z 1，Z 2，U，p， Q，R 1，R 2，R 3，R 3和R 3如本文所定义。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种疾病的严重性，包括中风，炎性疾病，自身免疫性疾病如SLE狼疮和牛皮癣，增殖性疾病如癌症，以及与器官移植相关的病症 。
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公开(公告)号：US07462612B2
公开(公告)日：2008-12-09
申请号：US11089701
申请日：2005-03-25
IPC分类号： C07D401/04 , C07D401/12 , A61K31/497 , A61K31/4439
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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