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    Microabrader with controlled abrasion features
    5.
    发明授权
    Microabrader with controlled abrasion features 有权
    具有受控磨损功能的微型机

    公开(公告)号：US07422567B2

    公开(公告)日：2008-09-09

    申请号：US10649395

    申请日：2003-08-27

    申请人： Alexander G. Lastovich ,  Frank E. Martin ,  M. Ishaq Haider ,  Richard P. Clarke ,  Jason B. Alarcon ,  John A. Mikszta ,  John P. Dekker, III ,  Weston Harding

    发明人： Alexander G. Lastovich ,  Frank E. Martin ,  M. Ishaq Haider ,  Richard P. Clarke ,  Jason B. Alarcon ,  John A. Mikszta ,  John P. Dekker, III ,  Weston Harding

    IPC分类号： A61B17/20

    CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61B2017/320004 ,  A61M31/002 ,  A61M37/00 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2037/0046 ,  A61M2037/0053

    摘要： An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.

    摘要翻译： 用于通过磨损过程将物质输送到皮肤中的研磨装置包括适于在期望的输送部位压紧皮肤的壳体，设置在壳体的上部开口中并可跨越壳体的下部开口移动的涂抹器头， 在至少一个沟槽中磨损输送部位，以及附着到涂抹器头部的磨料表面，由此壳体在输送位置处保持坚固和固定，并且壳体的结构和涂抹器头部控制磨损过程的参数。 特别地，控制施加到研磨器表面的力或压力的量，磨损表面移动穿过皮肤的速度和磨擦表面穿过皮肤的横向通过次数，使得研磨器装置提供沟槽 长度基本相同的深度，从而提供可重复的结果，即使不同的技术人员将磨擦装置应用于患者的皮肤。

    Device and method for delivering or withdrawing a substance through the skin
    6.
    发明授权
    Device and method for delivering or withdrawing a substance through the skin 有权
    通过皮肤递送或取出物质的装置和方法

    公开(公告)号：US06808506B2

    公开(公告)日：2004-10-26

    申请号：US10357502

    申请日：2003-02-04

    申请人： Alexander G. Lastovich ,  James K. Fentress ,  Julia Griggs ,  Ronald J. Pettis ,  Diane Sutter ,  Frank E. Martin ,  M. Ishaq Haider

    发明人： Alexander G. Lastovich ,  James K. Fentress ,  Julia Griggs ,  Ronald J. Pettis ,  Diane Sutter ,  Frank E. Martin ,  M. Ishaq Haider

    IPC分类号： A61B1720

    CPC分类号： A61M5/425 ,  A61M5/14244 ,  A61M5/3007 ,  A61M5/46 ,  A61M37/0015

    摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid. The dermal-access member extends at least 1 mm from the protrusion. A mechanism drives the device against the skin at a calculated speed of about 6 m/s to about 18 m/s.

    摘要翻译： 提供了一种用于通过至少一层皮肤递送或取出流体的装置。 一种装置包括具有顶面，底面，侧缘和至少一个通道的主体。 底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。 底面还包括设置在第二表面区域上的至少一个凸起突起。 突起具有从第一表面的高度大于第一距离。 在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。 真皮进入构件从突起延伸至少1mm。 机构以约6m / s至约18m / s的计算速度驱动装置抵靠皮肤。

    Intradermal Delivery Device With Crenellated Skin Engaging Surface Geometry
    7.
    发明申请
    Intradermal Delivery Device With Crenellated Skin Engaging Surface Geometry 审中-公开
    具有Crenellated皮肤接合表面几何的皮内输送装置

    公开(公告)号：US20100030148A1

    公开(公告)日：2010-02-04

    申请号：US12554121

    申请日：2009-09-04

    申请人： Paul G. Alchas ,  M. Ishaq Haider ,  Alexander G. Lastovich ,  Frank E. Martin

    发明人： Paul G. Alchas ,  M. Ishaq Haider ,  Alexander G. Lastovich ,  Frank E. Martin

    IPC分类号： A61M5/42

    CPC分类号： A61M5/425 ,  A61M5/14244 ,  A61M5/3007 ,  A61M5/46 ,  A61M37/0015

    摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. The device may include a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid.

    摘要翻译： 提供了一种用于通过至少一层皮肤递送或取出流体的装置。 该装置可以包括具有顶面，底面，侧边缘和至少一个通道的主体。 底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。 底面还包括设置在第二表面区域上的至少一个凸起突起。 突起具有从第一表面的高度大于第一距离。 在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。

    Device and method for delivering withdrawing a substance through the skin
    8.
    发明授权
    Device and method for delivering withdrawing a substance through the skin 有权
    用于递送物质通过皮肤递送的装置和方法

    公开(公告)号：US07083592B2

    公开(公告)日：2006-08-01

    申请号：US10951217

    申请日：2004-09-27

    申请人： Alexander G. Lastovich ,  James K. Fentress ,  Julia Griggs ,  Ronald J. Pettis ,  Diane Sutter ,  Frank E. Martin ,  M. Ishaq Haider

    发明人： Alexander G. Lastovich ,  James K. Fentress ,  Julia Griggs ,  Ronald J. Pettis ,  Diane Sutter ,  Frank E. Martin ,  M. Ishaq Haider

    IPC分类号： A61B17/20

    CPC分类号： A61M5/425 ,  A61M5/14244 ,  A61M5/3007 ,  A61M5/46 ,  A61M37/0015

    摘要： An apparatus for delivering or withdrawing a fluid through at least one layer of the skin is provided. A device includes a body having a top face, a bottom face, a side edge and at least one channel. The bottom face includes a first surface area and a second surface area adjacent to and recessed at a first distance from the first surface area. The bottom face further includes at least one raised protrusion disposed on the second surface area. The protrusion has a height from the first surface greater than the first distance. At least one dermal-access member is provided in the protrusion and is in fluid communication with the channel to deliver or withdraw the fluid. The dermal-access member extends at least 1 mm from the protrusion. A mechanism drives the device against the skin at a calculated speed of about 6 m/s to about 18 m/s.

    摘要翻译： 提供了一种用于通过至少一层皮肤递送或取出流体的装置。 一种装置包括具有顶面，底面，侧缘和至少一个通道的主体。 底面包括与第一表面区域相邻并且与第一表面区域第一距离凹陷的第一表面区域和第二表面区域。 底面还包括设置在第二表面区域上的至少一个凸起突起。 突起具有从第一表面的高度大于第一距离。 在突起中提供至少一个真皮进入构件，并且与通道流体连通以输送或抽出流体。 真皮进入构件从突起延伸至少1mm。 机构以约6m / s至约18m / s的计算速度驱动装置抵靠皮肤。