利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

49 条记录 (耗时 0.029 秒)

    Intradermal delivery of substances
    3.
    发明授权
    Intradermal delivery of substances 有权

    公开(公告)号：US08465468B1

    公开(公告)日：2013-06-18

    申请号：US09606909

    申请日：2000-06-29

    申请人： Ronald J. Pettis ,  James A. Down ,  Noel G. Harvey

    发明人： Ronald J. Pettis ,  James A. Down ,  Noel G. Harvey

    IPC分类号： A61M31/00

    CPC分类号： A61M5/46 ,  A61K38/28 ,  A61K38/29 ,  A61M5/158 ,  A61M5/32 ,  A61M5/3286 ,  A61M5/3291 ,  A61M5/3295 ,  A61M37/0015 ,  A61M2037/0038 ,  A61M2037/0061

    摘要： The present invention provides improved methods for ID delivery of drugs and other substances to humans or animals. The methods employ small gauge needles, especially microneedles, placed in the intradermal space to deliver the substance to the intradermal space as a bolus or by infusion. It has been discovered that the placement of the needle outlet within the skin and the exposed height of the needle outlet are critical for efficacious delivery of active substances via small gauge needles to prevent leakage of the substance out of the skin and to improve absorption within the intradermal space. The pharmacokinetics of hormone drugs delivered according to the methods of the invention have been found to be very similar to the pharmacokinetics of conventional SC delivery, indicating that ID administration according to the methods of the invention is likely to produce a similar clinical result (i.e., similar efficacy) with the advantage of reduction or elimination of pain for the patient. Delivery devices which place the needle outlet at an appropriate depth in the intradermal space and control the volume and rate of fluid delivery provide accurate delivery of the substance to the desired location without leakage.

    Disposable injection device
    6.
    发明授权
    Disposable injection device 有权
    一次性注射装置

    公开(公告)号：US07252651B2

    公开(公告)日：2007-08-07

    申请号：US10337413

    申请日：2003-01-07

    申请人： M. Ishaq Haider ,  Timothy Erskine ,  Ronald J. Pettis

    发明人： M. Ishaq Haider ,  Timothy Erskine ,  Ronald J. Pettis

    IPC分类号： A61M5/32

    CPC分类号： A61M5/3234 ,  A61M5/2033 ,  A61M5/2429 ,  A61M5/46 ,  A61M5/502 ,  A61M2005/2013 ,  A61M2005/3247 ,  A61M2037/0023

    摘要： An injection device is provided. The device includes a housing having a first end defining a first opening. A plunger is received within the first opening of the housing to move between first and second positions. A cartridge is disposed in the housing and has an interior serving as a reservoir for a drug. A delivery needle is disposed within the housing and is in fluid communication with the reservoir via an interruptible fluid channel. A locking mechanism is disposed in the housing. In the first position of the plunger the delivery needle is enclosed by the plunger and in the second position of the plunger the delivery needle is placed in an injection position and the plunger activates the locking mechanism whereby when the plunger returns to the first position the locking mechanism prevents the needle from being placed in the injection position.

    摘要翻译： 提供注射装置。 该装置包括具有限定第一开口的第一端的壳体。 柱塞被容纳在壳体的第一开口内以在第一和第二位置之间移动。 盒体设置在壳体中，并且具有用作药物的储存器的内部。 输送针设置在壳体内并且经由可中断流体通道与储存器流体连通。 锁定机构设置在壳体中。 在柱塞的第一位置，输送针由柱塞封闭，并且在柱塞的第二位置中，输送针被放置在注射位置，并且柱塞启动锁定机构，由此当柱塞返回到第一位置时，锁定 机构防止针头置于注射位置。

    Microdevice and method of delivering or withdrawing a substance through the skin of an animal
    7.
    发明授权
    Microdevice and method of delivering or withdrawing a substance through the skin of an animal 有权
    通过动物皮肤递送或取出物质的微型装置和方法

    公开(公告)号：US06689100B2

    公开(公告)日：2004-02-10

    申请号：US09971145

    申请日：2001-10-05

    申请人： Robert I. Connelly ,  Ronald J. Pettis

    发明人： Robert I. Connelly ,  Ronald J. Pettis

    IPC分类号： A61M500

    CPC分类号： A61M37/0015 ,  A61B5/14514 ,  A61M2037/0023 ,  A61M2037/003

    摘要： A device for withdrawing or delivering a substance through the skin of a patient includes a body and a skin penetrating device having a plurality of skin penetrating members, such microneedles. The body includes a bottom surface having a first inner surface area supporting the skin penetrating members and a second outer surface having an adhesive for attaching the device to the skin. In one embodiment, the firs inner surface is spaced outwardly from the second outer surface when the device is attached to the skin. The inner surface can have a textured visually wettable surface, such as an etched surface, to provide a visual indication of leakage from the interface between the skin penetrating members and the skin.

    摘要翻译： 用于通过患者皮肤抽出或递送物质的装置包括具有多个皮肤穿透构件的这种微针的身体和皮肤穿透装置。 本体包括具有支撑皮肤穿透构件的第一内表面区域和具有用于将装置附接到皮肤的粘合剂的第二外表面的底表面。 在一个实施例中，当装置附接到皮肤时，第一内表面与第二外表面向外间隔开。 内表面可以具有织构化的视觉上可润湿的表面，例如蚀刻表面，以提供从皮肤穿透构件和皮肤之间的界面渗漏的视觉指示。