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公开(公告)号：US07989633B2
公开(公告)日：2011-08-02
申请号：US11989277
申请日：2006-07-12
申请人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
发明人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
IPC分类号： C07D213/62
CPC分类号： C07D405/04
摘要： The present application relates to novel 4-chromenonyl-1,4-dihydropyridines, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的4-色烯酮基-1,4-二氢吡啶类，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是心血管疾病。
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公开(公告)号：US20090214675A1
公开(公告)日：2009-08-27
申请号：US11989279
申请日：2006-07-14
申请人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
发明人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
IPC分类号： A61K33/00 , C07D405/02 , A61K31/4433 , A61K31/60 , A61K31/704 , A61P9/00 , A61P9/12 , A61P13/12 , A61P25/00
CPC分类号： C07D405/04
摘要： The present application relates to novel 4-chromenonyl-1,4-dihydropyridinecarbonitriles, processes for their preparation, pharmaceutical compositions containing them, and their use for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的4-色烯酮基-1,4-二氢吡啶甲腈，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病，特别是心血管疾病的用途。
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公开(公告)号：US08058447B2
公开(公告)日：2011-11-15
申请号：US11989279
申请日：2006-07-14
申请人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
发明人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Figueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
IPC分类号： C07D213/62
CPC分类号： C07D405/04
摘要： The present application relates to novel 4-chromenonyl-1,4-dihydropyridinecarbonitriles, processes for their preparation, pharmaceutical compositions containing them, and their use for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的4-色烯酮基-1,4-二氢吡啶甲腈，其制备方法，含有它们的药物组合物及其用于治疗和/或预防疾病，特别是心血管疾病的用途。
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公开(公告)号：US20100022484A1
公开(公告)日：2010-01-28
申请号：US11989277
申请日：2006-07-12
申请人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Gigueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
发明人： Alexander Kuhl , Peter Kolkhof , Heike Heckroth , Karl-Heinz Schlemmer , Ingo Flamme , Santiago Gigueroa Perez , Heike Gielen-Haertwig , Rolf Grosser , Jens-Kerim Ergüden , Dieter Lang
IPC分类号： A61K31/60 , C07D405/02 , A61K31/4433 , A61P9/00 , A61P9/12 , A61P13/12 , A61P1/16
CPC分类号： C07D405/04
摘要： The present application relates to novel 4-chromenonyl-1,4-dihydropyridines, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的4-色烯酮基-1,4-二氢吡啶类，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途 ，特别是心血管疾病。
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5.发明授权4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases 有权4-（吡啶-3-基）-2（吡啶-2-基）-1,2-二氢-3H-吡唑-3-酮衍生物作为特异性HIF-裂解-4-羟化酶抑制剂用于治疗心血管和血液病公开(公告)号：US09085572B2
公开(公告)日：2015-07-21
申请号：US13594622
申请日：2012-08-24
申请人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
发明人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
IPC分类号： C07D401/14 , A61K31/4439 , C07D413/14
CPC分类号： C07D413/14 , C07D401/14
摘要： The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的联吡啶基 - 二氢吡唑酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US08252817B2
公开(公告)日：2012-08-28
申请号：US11919478
申请日：2006-04-15
申请人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
发明人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D413/14 , C07D401/14
摘要： The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的联吡啶基 - 二氢吡唑酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US20100035906A1
公开(公告)日：2010-02-11
申请号：US11919478
申请日：2006-04-15
申请人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
发明人： Ingo Flamme , Jens-Kerim Ergüden , Felix Oehme , Kai Thede , Gunter Karig , Alexander Kuhl , Hanno Wild , Joachim Schuhmacher , Peter Kolkhof , Lars Bärfacker , Joachim Hütter
IPC分类号： A61K31/506 , C07D401/14 , A61P9/00 , A61P13/12 , A61K31/444
CPC分类号： C07D413/14 , C07D401/14
摘要： The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的联吡啶基 - 二氢吡唑酮，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US08389520B2
公开(公告)日：2013-03-05
申请号：US12447192
申请日：2007-10-12
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
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9.发明申请SUBSTITUTED DIHYDROPYRAZOLONES AND USE THEREOF AS HIF-PROLYL-4 -HYDROXYLASE INHIBITORS 有权取代的二氢吡咯烷酮及其作为HIF-PROLYL-4-羟基酶抑制剂的用途公开(公告)号：US20120264704A1
公开(公告)日：2012-10-18
申请号：US12447201
申请日：2007-10-26
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/506 , C07D417/14 , A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/517 , A61K31/501 , A61K31/4709 , A61K31/497 , A61K31/55 , A61P7/10 , A61K31/616 , A61P31/04 , A61P35/00 , A61K31/7048 , A61P9/00 , A61P7/06 , A61P13/12 , C07D471/04 , A61K31/498 , A61K31/714 , C07D401/14
CPC分类号： C07D417/14 , C07D401/14
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US20100093803A1
公开(公告)日：2010-04-15
申请号：US12447207
申请日：2007-10-16
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
IPC分类号： A61K31/444 , C07D401/14
CPC分类号： C07D401/14
摘要： The present application relates to novel substituted dipyridyldihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的取代二吡啶基二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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