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公开(公告)号：US10208064B2
公开(公告)日：2019-02-19
申请号：US15323989
申请日：2015-07-09
申请人： MERCK SHARP & DOHME CORP. , Alexander Pasternak , Ian Davies , Fa-Xiang Ding , Jinlong Jiang , Shuzhi Dong , Xin Gu , Takao Suzuki , Joseph P. Vacca , Zhifa Pu , Shouning Xu
发明人： Alexander Pasternak , Ian Davies , Fa-Xiang Ding , Jinlong Jiang , Shuzhi Dong , Xin Gu , Takao Suzuki , Joseph P. Vacca , Zhifa Pu , Shouning Xu
IPC分类号： C07D513/10 , C07D519/00 , A61K45/06 , A61K31/435 , A61K31/4745 , A61K31/4375
摘要： The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：US20170197989A1
公开(公告)日：2017-07-13
申请号：US15323989
申请日：2015-07-09
申请人： Alexander PASTERNAK , Ian DAVIES , Fa-Xiang DING , Jinlong JIANG , Shuzhi DONG , Xin GU , Takao SUZUKI , Joseph P. VACCA , Zhifa PU , Shouning XU , Merck Sharp & Dohme Corp.
发明人： Alexander Pasternak , Ian Davies , Fa-Xiang Ding , Jinlong Jiang , Shuzhi Dong , Xin Gu , Takao Suzuki , Joseph P. Vacca , Zhifa Pu , Shouning Xu
IPC分类号： C07D519/00 , A61K31/4745 , A61K31/4375 , A61K31/435
CPC分类号： C07D519/00 , A61K31/435 , A61K31/4375 , A61K31/4745 , A61K45/06
摘要： The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：US20170283416A1
公开(公告)日：2017-10-05
申请号：US15505620
申请日：2015-10-26
申请人： Fa-Xiang Ding , Shuzhi Dong , Jinlong Jiang , Takao Suzuki , Joseph P. Vacca , Shouning Xu , Merck Sharp & Dohme Corp.
发明人： Fa-Xiang Ding , Shuzhi Dong , Jinlong Jiang , Takao Suzuki , Joseph P. Vacca , Shouning Xu
IPC分类号： C07D471/10 , A61K31/444 , A61K31/501 , A61K31/435
CPC分类号： C07D471/10 , A61K31/401 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/435 , A61K31/4422 , A61K31/444 , A61K31/501 , A61K31/55 , A61K2300/00
摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：US20180016263A1
公开(公告)日：2018-01-18
申请号：US15545891
申请日：2016-02-08
申请人： Alexander PASTERNAK , Jessica FRIE , Shuzhi DONG , Takao SUZUKI , Shouning XU , Merck Sharp & Dohme Corp.
发明人： Alexander Pasternak , Jessica Frie , Shuzhi Dong , Takao Suzuki , Shouning Xu
IPC分类号： C07D405/14 , A61K31/496 , C07D413/14
CPC分类号： C07D405/14 , A61K31/496 , A61K2300/00 , A61P9/00 , C07D413/14
摘要： The present invention provides compounds of Formula (I); and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：US09862720B2
公开(公告)日：2018-01-09
申请号：US15505620
申请日：2015-10-26
发明人： Fa-Xiang Ding , Shuzhi Dong , Jinlong Jiang , Takao Suzuki , Joseph P. Vacca , Shouning Xu
IPC分类号： C07D471/10 , A61K31/435 , A61K31/444 , A61K31/501
CPC分类号： C07D471/10 , A61K31/401 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/435 , A61K31/4422 , A61K31/444 , A61K31/501 , A61K31/55 , A61K2300/00
摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：US09718808B2
公开(公告)日：2017-08-01
申请号：US15106847
申请日：2015-01-05
发明人： Dipshikha Biswas , Fa-Xiang Ding , Shuzhi Dong , Xin Gu , Jinlong Jiang , Alexander Pasternak , Takao Suzuki , Joseph Vacca , Shouning Xu
IPC分类号： A61K31/501 , A61K31/403 , A61K31/4439 , A61K31/497 , A61K31/437 , A61K31/427 , A61K31/41 , C07D405/14 , C07D487/04 , C07D413/14 , C07D471/04 , C07D417/14 , A61K31/506 , A61K45/06
CPC分类号： C07D405/14 , A61K31/403 , A61K31/41 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：US10160751B2
公开(公告)日：2018-12-25
申请号：US15545891
申请日：2016-02-08
发明人： Alexander Pasternak , Jessica Frie , Shuzhi Dong , Takao Suzuki , Shouning Xu
IPC分类号： A01N43/54 , A61K31/505 , C07D405/14 , C07D413/14 , A61K31/496 , A61P9/00
摘要： The present invention provides compounds of Formula (I); and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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公开(公告)号：US20170037037A1
公开(公告)日：2017-02-09
申请号：US15106847
申请日：2015-01-05
发明人： Dipshikha Biswas , Fa-Xiang Ding , Shuzhi Dong , Xin Gu , Jinlong Jiang , Alexander Pasternak , Takao Suzuki , Joseph Vacca , Shouning Xu
IPC分类号： C07D405/14 , A61K31/501 , A61K31/403 , A61K31/4439 , C07D487/04 , C07D413/14 , A61K31/497 , C07D471/04 , A61K31/437 , C07D417/14 , A61K31/427 , A61K45/06 , A61K31/41
CPC分类号： C07D405/14 , A61K31/403 , A61K31/41 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K45/06 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
摘要翻译： 本发明提供了作为ROMK（Kir1.1）通道抑制剂的式（I）化合物及其药学上可接受的盐。 这些化合物可以用作利尿剂和/或利尿钠剂，并且用于治疗和预防包括心血管疾病如高血压，心力衰竭和慢性肾脏疾病以及与过量的盐和水保留有关的病症的医学病症。
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