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    Method and apparatus for high resolution ex-situ NMR spectroscopy
    3.
    发明授权
    Method and apparatus for high resolution ex-situ NMR spectroscopy 有权
    用于高分辨率非原位NMR光谱的方法和装置

    公开(公告)号：US06674282B2

    公开(公告)日：2004-01-06

    申请号：US10218974

    申请日：2002-08-13

    申请人： Alexander Pines ,  Carlos A. Meriles ,  Henrike Heise ,  Dimitrios Sakellariou ,  Adam Moule

    发明人： Alexander Pines ,  Carlos A. Meriles ,  Henrike Heise ,  Dimitrios Sakellariou ,  Adam Moule

    IPC分类号： G01V300

    CPC分类号： G01R33/445 ,  G01R33/3808 ,  G01R33/46 ,  G01R33/4608 ,  G01R33/4616 ,  G01R33/48 ,  G01R33/485

    摘要： A method and apparatus for ex-situ nuclear magnetic resonance spectroscopy for use on samples outside the physical limits of the magnets in inhomogeneous static and radio-frequency fields. Chemical shift spectra can be resolved with the method using sequences of correlated, composite z-rotation pulses in the presence of spatially matched static and radio frequency field gradients producing nutation echoes. The amplitude of the echoes is modulated by the chemical shift interaction and an inhomogeneity free FID may be recovered by stroboscopically sampling the maxima of the echoes. In an alternative embodiment, full-passage adiabatic pulses are consecutively applied. One embodiment of the apparatus generates a static magnetic field that has a variable saddle point.

    摘要翻译： 用于非均匀静态和射频场中磁体物理极限外的样品的非原位核磁共振光谱法的方法和装置。 在存在空间匹配的静态和射频场梯度产生章动回波的情况下，可以使用相关的复合z旋转脉冲序列来解决化学位移谱。 回波的幅度由化学位移相互作用调制，并且不均匀性的自由FID可以通过频谱采样回波的最大值来恢复。 在替代实施例中，连续应用全通道绝热脉冲。 该装置的一个实施例产生具有可变鞍点的静态磁场。

    Apparatus for high-resolution NMR spectroscopy and/or imaging with an improved filling factor and RF field amplitude
    6.
    发明授权
    Apparatus for high-resolution NMR spectroscopy and/or imaging with an improved filling factor and RF field amplitude 失效
    用于高分辨率NMR光谱和/或具有改进的填充因子和RF场振幅的成像装置

    公开(公告)号：US08106657B2

    公开(公告)日：2012-01-31

    申请号：US11993793

    申请日：2006-07-05

    申请人： Dimitrios Sakellariou ,  Jacques-François Jacquinot

    发明人： Dimitrios Sakellariou ,  Jacques-François Jacquinot

    IPC分类号： G01V3/00

    CPC分类号： G01R33/34053 ,  G01R33/307 ,  G01R33/34092

    摘要： The present invention concerns an apparatus (1′) for NMR spectroscopy and/or NMR imaging of a sample. The apparatus comprises a static probe comprising an outer coil for excitation of nuclei of the sample by generating an incident radio frequency field at the Larmor frequency of the nuclei, and for reception of a return radio frequency field emitted by the sample, and a sensitive inner coil (6a′) which is mounted closely around or in contact with the sample container and which is wirelessly coupled to the outer coil by an electromagnetic radio frequency field. The sensitive inner coil is embedded in an inner spinning rotor (2) which is rotatively mounted inside the static probe and which is integral with the sample container, so that the filling factor and the radio frequency field amplitude in the sensitive coil are maximized.

    摘要翻译： 本发明涉及用于样品的NMR光谱和/或NMR成像的装置（1'）。 该装置包括静电探针，该静态探针包括用于通过产生原子的拉莫尔频率的入射射频场和用于接收样品发射的返回射频场的用于激发样品核的外部线圈，以及敏感内部 线圈（6a'），其紧密地安装在样品容器周围或与样品容器接触，并且通过电磁射频场与外部线圈无线耦合。 敏感内圈嵌入内旋转转子（2），旋转安装在静电探头的内部，与样品容器成一体，使感光线圈中的填充因子和射频场振幅最大化。

    Cylindrical permanent magnet device generating a controlled magnetic field at a distance from the surface thereof
    7.
    发明授权
    Cylindrical permanent magnet device generating a controlled magnetic field at a distance from the surface thereof 有权
    圆柱形永久磁铁装置产生距其表面一定距离处的受控磁场

    公开(公告)号：US09128167B2

    公开(公告)日：2015-09-08

    申请号：US13063864

    申请日：2010-08-27

    申请人： Dimitrios Sakellariou ,  Guy Aubert ,  Cédric Hugon

    发明人： Dimitrios Sakellariou ,  Guy Aubert ,  Cédric Hugon

    IPC分类号： H01F7/02 ,  G01R33/383 ,  G01R33/38 ,  G01R33/30

    CPC分类号： G01R33/383 ,  G01R33/30 ,  G01R33/307 ,  G01R33/3808 ,  H01F7/0278

    摘要： The cylindrical permanent magnet device includes at least one basic structure (10) having a longitudinal axis (z) and a set (20) of coaxial magnetized structures (21, 22, 23, 24) that are in the form of non-contiguous rings of axis that is the longitudinal axis (z) and that are disposed on the same side of the basic structure (10), defining an exterior surface perpendicular to the longitudinal axis (z) to produce a magnetic field (B0) outside the magnet device in an exterior area of interest (3) situated at a predetermined distance from the exterior surface along the longitudinal axis (z). At least one of the coaxial magnetized structures (21, 22, 23, 24) in the form of rings is divided into components in the form of non-contiguous identical sectors. The basic structure (10) and the set (20) of coaxial magnetized structures (21, 22, 23, 24) in the form of rings are magnetized in the same direction (M) to create in the exterior area of interest (3) an induced magnetic field (B0) that is homogeneous or that has a constant gradient and that is oriented at a predetermined angle (θ2) relative to the longitudinal axis (z).

    摘要翻译： 圆柱形永久磁铁装置包括至少一个基本结构（10），其具有纵向轴线（z）和一组（20）的同轴磁化结构（21,22,23,24），其为不连续环形 作为纵向轴线（z）并且被设置在基础结构（10）的同一侧上，限定垂直于纵向轴线（z）的外表面，以在磁体装置外部产生磁场（B0） 在距离外表面沿着纵向轴线（z）预定距离的感兴趣的外部区域（3）中。 环形形式的至少一个同轴磁化结构（21,22,23,24）被分成不连续相同扇区形式的部件。 以环形形式的同轴磁化结构（21,22,23,24）的基本结构（10）和组（20）在相同的方向（M）上磁化以在感兴趣的外部区域（3）中产生， 感应磁场（B0），其是均匀的或具有恒定的梯度并且相对于纵向轴线（z）以预定角度（θ; 2）定向。

    CYLINDRICAL PERMANENT MAGNET DEVICE WITH AN INDUCED MAGNETIC FIELD HAVING A PREDETERMINED ORIENTATION, AND PRODUCTION METHOD
    8.
    发明申请
    CYLINDRICAL PERMANENT MAGNET DEVICE WITH AN INDUCED MAGNETIC FIELD HAVING A PREDETERMINED ORIENTATION, AND PRODUCTION METHOD 审中-公开
    具有预测方位的感应磁场的圆柱永磁体装置及其制造方法

    公开(公告)号：US20120098630A1

    公开(公告)日：2012-04-26

    申请号：US13063861

    申请日：2010-08-27

    申请人： Dimitrios Sakellariou ,  Cédric Hugon ,  Guy Aubert

    发明人： Dimitrios Sakellariou ,  Cédric Hugon ,  Guy Aubert

    IPC分类号： H01F7/02 ,  H01F41/02

    CPC分类号： G01R33/383 ,  G01R33/30 ,  G01R33/307 ,  G01R33/3802 ,  H01F7/0278 ,  Y10T29/49075

    摘要： A cylindrical permanent magnet device that induces in a central area of interest a homogeneous magnetic field of predetermined orientation relative to a longitudinal axis (z) of the device comprises first and second annular magnetized structures (111, 121) disposed symmetrically relative to a plane (P) that is perpendicular to the longitudinal axis (z) and contains the central area of interest, and a third annular magnetized structure (112, 122) disposed between the first and second structures (111, 121) and also disposed symmetrically relative to the plane (P) of symmetry. The first, second, and third annular magnetized structures (111, 121, 112, 122) are divided into components in the form of sectors. The third annular magnetized structure (112, 122) is divided into at least two slices (112A, 112B, 122A, 122B) along the longitudinal axis (z) and in that all the components of the first, second and third annular magnetized structures (111, 121, 112, 122) are magnetized in the same direction to create in the central area of interest a homogeneous induced magnetic field at a predetermined angle to the longitudinal axis (z). The parts of the device may be assembled before the assembly is magnetized.

    摘要翻译： 感兴趣的中心区域中的圆柱形永久磁铁装置相对于装置的纵向轴线（z）在预定取向上形成均匀的磁场包括相对于平面对称设置的第一和第二环形磁化结构（111,121） P），其垂直于所述纵向轴线（z）并且包含所述感兴趣的中心区域，以及设置在所述第一和第二结构（111,121）之间并且相对于所述第一和第二结构（111,121）对称设置的第三环形磁化结构（112,122） 平面（P）对称。 第一，第二和第三环形磁化结构（111,121,112,122）被划分为扇形形式的部件。 第三环形磁化结构（112,122）沿着纵向轴线（z）分成至少两个切片（112A，112B，122A，122B），并且所述第一，第二和第三环形磁化结构的所有部件 111,121,112,122）在相同方向上磁化，以在感兴趣的中心区域中产生与纵向轴线（z）成预定角度的均匀感应磁场。 在组件被磁化之前，装置的部件可以被组装。

    CYLINDRICAL PERMANENT MAGNET DEVICE GENERATING A CONTROLLED MAGNETIC FIELD AT A DISTANCE FROM THE SURFACE THEREOF
    9.
    发明申请
    CYLINDRICAL PERMANENT MAGNET DEVICE GENERATING A CONTROLLED MAGNETIC FIELD AT A DISTANCE FROM THE SURFACE THEREOF 有权
    从其表面距离产生控制磁场的圆柱永磁体装置

    公开(公告)号：US20120098539A1

    公开(公告)日：2012-04-26

    申请号：US13063864

    申请日：2010-08-27

    申请人： Dimitrios Sakellariou ,  Guy Aubert ,  Cédric Hugon

    发明人： Dimitrios Sakellariou ,  Guy Aubert ,  Cédric Hugon

    IPC分类号： G01R33/32

    CPC分类号： G01R33/383 ,  G01R33/30 ,  G01R33/307 ,  G01R33/3808 ,  H01F7/0278

    摘要： The cylindrical permanent magnet device includes at least one basic structure (10) having a longitudinal axis (z) and a set (20) of coaxial magnetized structures (21, 22, 23, 24) that are in the form of non-contiguous rings of axis that is the longitudinal axis (z) and that are disposed on the same side of the basic structure (10), defining an exterior surface perpendicular to the longitudinal axis (z) to produce a magnetic field (B0) outside the magnet device in an exterior area of interest (3) situated at a predetermined distance from the exterior surface along the longitudinal axis (z). At least one of the coaxial magnetized structures (21, 22, 23, 24) in the form of rings is divided into components in the form of non-contiguous identical sectors. The basic structure (10) and the set (20) of coaxial magnetized structures (21, 22, 23, 24) in the form of rings are magnetized in the same direction (M) to create in the exterior area of interest (3) an induced magnetic field (B0) that is homogeneous or that has a constant gradient and that is oriented at a predetermined angle (θ2) relative to the longitudinal axis (z).

    摘要翻译： 圆柱形永磁体装置包括至少一个基本结构（10），其具有纵向轴线（z）和一组（20）的同轴磁化结构（21,22,23,24），它们是非连续环形 作为纵向轴线（z）并且被设置在基础结构（10）的同一侧上，限定垂直于纵向轴线（z）的外表面，以在磁体装置外部产生磁场（B0） 位于距离外表面沿着纵向轴线（z）预定距离的感兴趣的外部区域（3）中。 环形形式的至少一个同轴磁化结构（21,22,23,24）被分成不连续相同扇区形式的部件。 以环形形式的同轴磁化结构（21,22,23,24）的基本结构（10）和组（20）在相同的方向（M）上磁化以在感兴趣的外部区域（3）中产生， 感应磁场（B0），其是均匀的或具有恒定的梯度并相对于纵向轴线（z）以预定角度（θ; 2）定向。

    MAGNETISED STRUCTURE INDUCING A HOMOGENEOUS FIELD, IN THE CENTRE THEREOF, WITH A PRE-DETERMINED ORIENTATION
    10.
    发明申请
    MAGNETISED STRUCTURE INDUCING A HOMOGENEOUS FIELD, IN THE CENTRE THEREOF, WITH A PRE-DETERMINED ORIENTATION 有权
    在中心的诱导均质场的磁化结构与预先确定的方位

    公开(公告)号：US20120013338A1

    公开(公告)日：2012-01-19

    申请号：US13063875

    申请日：2010-08-27

    申请人： Dimitrios Sakellariou ,  Cédric Hugon ,  Guy Aubert

    发明人： Dimitrios Sakellariou ,  Cédric Hugon ,  Guy Aubert

    IPC分类号： G01R33/44

    CPC分类号： G01R33/383 ,  G01R33/307 ,  H01F7/0278

    摘要： A magnetized structure that induces in a central area of interest a homogeneous magnetic field of predetermined orientation relative to a longitudinal axis (z) of the structure comprises at least two magnetized rings (110, 120) disposed symmetrically relative to a plane (P) that is perpendicular to the longitudinal axis (z) and that contains the central area of interest, and at least one median annular magnetized structure disposed at least partly between the two magnetized rings (110, 120) and also disposed symmetrically relative to the plane (P) of symmetry, one of the two magnetized rings (110) being magnetized radially relative to the longitudinal axis (z) with divergent magnetization and the other of the two magnetized rings (120) being magnetized radially relative to the longitudinal axis (z) with convergent magnetization, and the median annular magnetized structure being magnetized with an orientation different from that of the magnetization of the two magnetized rings (110, 120). The median annular magnetized structure comprises at least one magnetized ring (150) having a magnetization distribution of orientation that varies as in Halbach dipoles and the first two magnetized rings (110, 120) and the median annular magnetized structure are each divided into individual components in the form of regularly distributed identical sectors.

    摘要翻译： 感兴趣的中心区域的磁化结构相对于该结构的纵向轴线（z）具有预定取向的均匀磁场包括相对于平面（P）对称设置的至少两个磁化环（110,120），所述至少两个磁化环 垂直于所述纵向轴线（z）并且包含所述感兴趣的中心区域，以及至少一个中间环形磁化结构，其至少部分地设置在所述两个磁化环（110,120）之间，并且还相对于所述平面（P ）对称，两个磁化环（110）之一相对于纵向轴线（z）径向磁化，具有发散磁化，并且两个磁化环（120）中的另一个相对于纵向轴线（z）径向磁化， 收敛磁化，并且中间环形磁化结构被磁化，其方向不同于两个磁化环（110,120）的磁化强度 ）。 中间环形磁化结构包括至少一个磁化环（150），其具有如Halbach偶极子中变化的取向的磁化分布，并且前两个磁化环（110,120）和中间环形磁化结构各自被分成 定期分发相同部门的形式。