公开(公告)号：US06818202B2

公开(公告)日：2004-11-16

申请号：US10164324

申请日：2002-06-05

申请人： Alexander Pines ,  Thomas Budinger ,  Gil Navon ,  Yi-Qiao Song ,  Stephan Appelt ,  Angelo Bifone ,  Rebecca Taylor ,  Boyd Goodson ,  Roberto Seydoux ,  Toomas Room ,  Tanja Pietrass

发明人： Alexander Pines ,  Thomas Budinger ,  Gil Navon ,  Yi-Qiao Song ,  Stephan Appelt ,  Angelo Bifone ,  Rebecca Taylor ,  Boyd Goodson ,  Roberto Seydoux ,  Toomas Room ,  Tanja Pietrass

IPC分类号： A61B5055

CPC分类号： G01R33/5601 ,  A61K49/1815 ,  G01R33/282 ,  G01R33/62 ,  Y10T436/24

摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.

摘要翻译： 本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。 更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。 此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。 当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。

公开(公告)号：US06426058B1

公开(公告)日：2002-07-30

申请号：US08825475

申请日：1997-03-28

申请人： Alexander Pines ,  Thomas Budinger ,  Gil Navon ,  Yi-Qiao Song ,  Stephan Appelt ,  Angelo Bifone ,  Rebecca Taylor ,  Boyd Goodson ,  Roberto Seydoux ,  Toomas Room ,  Tanja Pietrass

发明人： Alexander Pines ,  Thomas Budinger ,  Gil Navon ,  Yi-Qiao Song ,  Stephan Appelt ,  Angelo Bifone ,  Rebecca Taylor ,  Boyd Goodson ,  Roberto Seydoux ,  Toomas Room ,  Tanja Pietrass

IPC分类号： A61B505

CPC分类号： G01R33/5601 ,  A61K49/1815 ,  G01R33/282 ,  G01R33/62 ,  Y10T436/24

摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.

摘要翻译： 本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。 更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。 此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。 当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。

公开(公告)号：US07385395B2

公开(公告)日：2008-06-10

申请号：US10940297

申请日：2004-09-13

申请人： Alexander Pines ,  Thomas Budinger ,  Gil Navon ,  Yi-Qiao Song ,  Stephan Appelt ,  Angelo Bifone ,  Rebecca Taylor ,  Boyd Goodson ,  Roberto Seydoux ,  Toomas Room ,  Tanja Pietrass

发明人： Alexander Pines ,  Thomas Budinger ,  Gil Navon ,  Yi-Qiao Song ,  Stephan Appelt ,  Angelo Bifone ,  Rebecca Taylor ,  Boyd Goodson ,  Roberto Seydoux ,  Toomas Room ,  Tanja Pietrass

IPC分类号： G01V3/00 ,  G01N24/00 ,  A61B5/055

CPC分类号： G01R33/5601 ,  A61K49/1815 ,  G01R33/282 ,  G01R33/62 ,  Y10T436/24

摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.

摘要翻译： 本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。 更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。 此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。 当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。

公开(公告)号：US20050030026A1

公开(公告)日：2005-02-10

申请号：US10940297

申请日：2004-09-13

申请人： Alexander Pines ,  Thomas Budinger ,  Gil Navon ,  Yi-Qiao Song ,  Stephan Appelt ,  Angelo Bifone ,  Rebecca Taylor ,  Boyd Goodson ,  Roberto Seydoux ,  Toomas Room ,  Tanja Pietrass

发明人： Alexander Pines ,  Thomas Budinger ,  Gil Navon ,  Yi-Qiao Song ,  Stephan Appelt ,  Angelo Bifone ,  Rebecca Taylor ,  Boyd Goodson ,  Roberto Seydoux ,  Toomas Room ,  Tanja Pietrass

IPC分类号： G01R33/48 ,  A61B5/055 ,  A61K49/18 ,  G01R33/28 ,  G01R33/62 ,  G01V3/00 ,  A61B5/05

CPC分类号： G01R33/5601 ,  A61K49/1815 ,  G01R33/282 ,  G01R33/62 ,  Y10T436/24

摘要： The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.

摘要翻译： 本发明一般涉及用于光谱和成像的核磁共振（NMR）技术。 更具体地，本发明涉及超极化惰性气体（例如Xe和He）用于增强和改善NMR和MRI的方法。 此外，本发明的超极化气体溶液在体外和体内都可用于研究系统的动力学或结构。 当与体内或体外的生物系统一起使用时，靶向超极化气体并将其递送到系统内的特定区域在本发明的范围内。