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    Immunoassays for antibodies which bind to the acquired immunodeficiency virus
    2.
    发明授权
    Immunoassays for antibodies which bind to the acquired immunodeficiency virus 失效
    与获得性免疫缺陷病毒结合的抗体的免疫测定

    公开(公告)号：US4877725A

    公开(公告)日：1989-10-31

    申请号：US718140

    申请日：1985-04-01

    申请人： Alexander R. Neurath ,  Nathan Strick

    发明人： Alexander R. Neurath ,  Nathan Strick

    IPC分类号： G01N33/569

    CPC分类号： G01N33/56988 ,  Y10S435/81 ,  Y10S435/948 ,  Y10S435/974 ,  Y10S530/806 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/826

    摘要： A process for the detection of antibodies to HTLV III/LAV comprising:(A) mixing an unknown serum sample with a crude HTLV III/LAV viral antigen selected from the group consisting of(1) an antigen comprising P24 core protein and Penv protein;(2) a P24 antigen and(3) a Penv antigen,(B) incubating the resultant mixture from step (A);(C) contacting the mixture of step (B) with a solid substrate coated with antibody to HTLV III/LAV;(D) incubating the mass from step (C);(E) washing the mass from step (D);(F) contacting the mass from step (E) with a labeled antibody to HTLV III/LAV;(G) incubating the mass from step (F);(H) washing the mass from step (G);(I) assaying the label in the mass from step (H);(J) as a negative control, mixing a serum sample known to be negative to HTLV III/LAV antibody with a diluent;(K) subjecting the mass from step (J) to steps (B) to (I);(L) as a positive control, mixing a predetermined amount of the crude HTLV III/LAV viral antigen and the diluent;(M) subjecting the mass from step (L) to steps (B) to (I); and(N) comparing the results of the assay for the label from steps (I), (K) and (M).

    摘要翻译： 用于检测HTLV III / LAV的抗体的方法，包括：（A）将未知血清样品与选自（1）包含P24核心蛋白和Penv蛋白的抗原的粗HTLV III / LAV病毒抗原混合; （2）P24抗原和（3）Penv抗原，（B）温育来自步骤（A）的所得混合物; （C）使步骤（B）的混合物与涂覆有HTLV III / LAV抗体的固体基质接触; （D）将来自步骤（C）的质量孵育; （E）从步骤（D）洗涤质量; （F）使来自步骤（E）的质量与HTLV III / LAV的标记抗体接触; （G）温育步骤（F）的质量; （H）从步骤（G）洗涤质量; （I）测定步骤（H）中质量的标记物; （J）作为阴性对照，将已知为阴性的血清样品与稀释剂混合至HTLV III / LAV抗体; （K）使步骤（J）的步骤（B）至（I） （L）作为阳性对照，混合预定量的粗制HTLV III / LAV病毒抗原和稀释剂; （M）使来自步骤（L）的物质经历步骤（B）至（I）; 和（N）比较来自步骤（I），（K）和（M）的标记物的测定结果。

    Topical gel cosmetic formulation of cellacefate for the control of acne and rosacea
    4.
    发明申请
    Topical gel cosmetic formulation of cellacefate for the control of acne and rosacea 审中-公开
    用于控制痤疮和酒渣鼻的细胞外壳的局部凝胶化妆品配方

    公开(公告)号：US20090234027A1

    公开(公告)日：2009-09-17

    申请号：US12378289

    申请日：2009-02-12

    申请人： Nathan Strick

    发明人： Nathan Strick

    IPC分类号： A61K47/38 ,  C07H3/00 ,  A61P17/10

    CPC分类号： A61K8/731 ,  A61Q17/005 ,  A61Q19/00

    摘要： Compositions for the treatment of acne or rosacea on the skin are described. Also provided are methods of forming the compositions as well as the treatment itself. The composition includes as an active ingredient cellulose acetate phthalate (CAP).

    摘要翻译： 描述了治疗皮肤上痤疮或红斑痤疮的组合物。 还提供了形成组合物以及治疗本身的方法。 该组合物包括作为活性成分的醋酸邻苯二甲酸纤维素（CAP）。

    Biodegradable microbicidal vaginal barrier device
    5.
    发明授权
    Biodegradable microbicidal vaginal barrier device 失效

    公开(公告)号：US06572875B2

    公开(公告)日：2003-06-03

    申请号：US09966924

    申请日：2001-09-28

    申请人： Alexander Robert Neurath ,  Nathan Strick

    发明人： Alexander Robert Neurath ,  Nathan Strick

    IPC分类号： A61F606

    CPC分类号： A61K9/0036 ,  A61K9/122

    摘要： An intravaginal bio-erodible microbicidal barrier device. The device comprises (a) at least one micronized compound selected from the group consisting of cellulose acetate phthalate and hydroxypropylmethylcellulose phthalate, and (b) at least one water soluble or water dispersible cellulose compound selected from the group consisting of hydroxypropylmethylcellulose, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxyethylmethylcellulose, hydroxyethylethylcellulose and hydroxypropylethylcellulose. The device is prepared by a combination of foaming, freezing and freeze-drying processes.

    Labeled anti-hapten antibodies and their use as a universal reagent for solid phase radio- and/or enzyme-immunoassays
    6.
    发明授权
    Labeled anti-hapten antibodies and their use as a universal reagent for solid phase radio- and/or enzyme-immunoassays 失效
    标记的抗半抗原抗体及其作为固相放射和/或酶免疫测定的通用试剂的用途

    公开(公告)号：US4495296A

    公开(公告)日：1985-01-22

    申请号：US41127

    申请日：1979-05-21

    申请人： A. Robert Neurath ,  Nathan Strick

    发明人： A. Robert Neurath ,  Nathan Strick

    IPC分类号： G01N33/532 ,  G01N33/543 ,  G01N33/52 ,  G01N33/54 ,  G01N33/56

    CPC分类号： G01N33/532 ,  G01N33/54306 ,  Y10S435/966 ,  Y10S436/804 ,  Y10S436/822

    摘要： A process for detecting the presence of an antigen in a specimen is described, which process comprises:(A) contacting said specimen with a substrate coated with antibodies of said antigen, incubating the contacted substrate and washing the substrate;(B) contacting the washed material of step (A) with a hapten conjugated antibody against said antigen, incubating the so-contacted material and washing the so-incubated material;(C) contacting the washed material of step (B) with a radioactive material labeled or enzyme containing anti-hapten antibody, incubating the so-contacted material and washing the same; and(D) effecting radioimmunoassay if said antibody is radioactive or enzyme labeled immunoassay if said antibody contains an enzyme moiety.Quantitative determination of the antigen in the specimen is effected by comparing the counts of the radioimmunoassay or the concentration of enzyme against a standard as by photocolormetric methods.

    摘要翻译： 描述了用于检测样品中抗原存在的方法，该方法包括：（A）使所述样品与涂有所述抗原抗体的底物接触，孵育接触的基质并洗涤底物; （B）使所洗涤的步骤（A）的材料与针对所述抗原的半抗原共轭抗体接触，培养如此接触的材料并洗涤如此温育的材料; （C）使经过洗涤的步骤（B）的材料与标记或含有抗半抗原抗体的酶的放射性物质接触，孵育如此接触的材料并洗涤; 和（D）如果所述抗体是放射性的，则进行放射免疫测定，如果所述抗体含有酶部分则进行酶标记的免疫测定。 通过比较放射免疫测定的计数或酶的浓度与标准方法的比较，可以定量测定样品中的抗原。

    RAPIDLY DISPERSIBLE VAGINAL TABLET THAT PROVIDES A BIOADHESIVE GEL
    7.
    发明申请
    RAPIDLY DISPERSIBLE VAGINAL TABLET THAT PROVIDES A BIOADHESIVE GEL 审中-公开
    提供生物凝胶的快速不平的血管片

    公开(公告)号：US20110159091A1

    公开(公告)日：2011-06-30

    申请号：US12601517

    申请日：2008-05-23

    申请人： Alan Stone ,  Alexander Robert Neurath ,  Nathan Strick

    发明人： Alan Stone ,  Alexander Robert Neurath ,  Nathan Strick

    IPC分类号： A61K9/20 ,  A61K31/717 ,  A61K31/765 ,  A61K31/775 ,  A61P31/18 ,  A61P31/20 ,  A61P31/04 ,  A61P33/02 ,  A61K31/737 ,  A61K31/565 ,  A61K31/4174 ,  A61K31/675 ,  A61P15/16

    CPC分类号： A61K9/0034 ,  A61K9/2018 ,  A61K31/00

    摘要： A tablet for insertion into a vagina including 0.01 to 500 mg of a vaginal medication, such as a microbicide, such as cellulose acetate 1,2-benzenedicarboxylate (CAP); 100 to 500 mg of mannitol powder; 50 to 300 mg of inert microcrystalline cellulose; 10 to 80 mg of hydroxypropyl methylcellulose; 50 to 250 mg of glycerol and optionally 2 to 4 mg of at least one preservative which protects against microbicidal contamination and discourages the growth of yeast in the vagina. The tablet which includes CAP as the vaginal medication is vaginally administered before coitus in methods for preventing the sexual transmission of HIV-1, HIV-2, herpesvirus, or an infection caused by Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Haemophilus ducreyi or Treponema pallidum. The tablet which includes CAP as the vaginal medication is vaginally administered to prevent or treat bacterial vaginosis.

    摘要翻译： 用于插入阴道的片剂，其包含0.01至500mg的阴道药物，例如杀微生物剂，例如1,2-苯二羧酸乙酸纤维素酯（CAP）; 100〜500mg甘露糖醇粉末; 50〜300mg惰性微晶纤维素; 10至80mg羟丙基甲基纤维素; 50至250mg的甘油和任选的2至4mg的至少一种防腐剂，其防止杀微生物污染并阻止酵母在阴道中的生长。 包括CAP作为阴道药物的片剂在防止HIV-1，HIV-2，疱疹病毒的性传播或由淋病奈瑟氏球菌，沙眼衣原体，阴道毛滴虫，杜氏乳杆菌或梅毒螺旋体引起的感染的方法之前阴道给药 苍白球 包括CAP作为阴道药物的片剂被阴道施用以预防或治疗细菌性阴道病。

    Composition for the treatment of inflammatory conditions
    8.
    发明授权
    Composition for the treatment of inflammatory conditions 有权
    用于治疗炎症状况的组合物

    公开(公告)号：US07772213B2

    公开(公告)日：2010-08-10

    申请号：US11494722

    申请日：2006-07-27

    申请人： Nathan Strick

    发明人： Nathan Strick

    IPC分类号： A61K31/70

    CPC分类号： A61K31/717

    摘要： A novel treatment for topical inflammatory conditions such as acne, eczema, shingles, insect bites and hives is provided, consisting of the application of a pharmaceutical cream or ointment which incorporates hydroxypropyl methylcellulose acetate succinate (“HPMCAS”) in a micronized form and which preferably contains one or more thickeners, a bio-adhesive agent and water so that the formulation, when applied, can stick to the area to be treated.

    摘要翻译： 提供了一种用于局部炎性病症如痤疮，湿疹，带状疱疹，昆虫叮咬和荨麻疹的新型治疗方法，其包括以微粉化形式掺入羟丙基甲基纤维素乙酸琥珀酸酯（“HPMCAS”）的药用霜剂或软膏剂， 含有一种或多种增稠剂，生物粘合剂和水，使得当施用时，制剂可以粘附到待处理的区域。

    Water dispersible film
    10.
    发明申请
    Water dispersible film 审中-公开
    水分散膜

    公开(公告)号：US20050070501A1

    公开(公告)日：2005-03-31

    申请号：US10918915

    申请日：2004-08-16

    申请人： Alexander Neurath ,  Nathan Strick ,  Yun-Yao Li

    发明人： Alexander Neurath ,  Nathan Strick ,  Yun-Yao Li

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K31/716

    CPC分类号： A61K31/716 ,  A61K9/0034 ,  A61K9/7007

    摘要： A soft, pliable cellulose acetate phthalate (CAP)—hydroxypropyl cellulose (HPC) composite film is provided which is generated by casting from organic solvent mixtures containing ethanol. The film rapidly reduces the infectivity of several sexually transmitted disease pathogens, including the human immunodeficiency virus (HIV-1), herpesvirus (HSV), non-viral sexually transmitted disease pathogens (such as Neisseria gonorrhoeae, Haemophilus ducreyi, Chlamydia trachomatis and Treponema pallidum) and bacteria associated with bacterial vaginosis (BV). The film is converted into a gel/cream and thus does not have to be removed following application and use. In addition to being a topical microbicide, the film can be employed for the mucosal delivery of pharmaceuticals other than cellulose acetate phthalate.

    摘要翻译： 提供柔软的，柔韧的乙酸邻苯二甲酸纤维素（CAP） - 羟丙基纤维素（HPC）复合膜，其通过从含有乙醇的有机溶剂混合物中浇铸而产生。 该片迅速降低了几种性传播疾病病原体的感染性，包括人类免疫缺陷病毒（HIV-1），疱疹病毒（HSV），非病毒性传播疾病病原体（如淋病奈瑟氏球菌，杜氏血吸虫，沙眼衣原体和苍白密螺旋体 ）和细菌性阴道炎相关的细菌（BV）。 该胶片被转化为凝胶/霜剂，因此在使用和使用后不需要除去。 除了是局部杀微生物剂之外，该膜还可用于除了邻苯二甲酸乙酸纤维素之外的药物的粘膜递送。