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    Stabilized protein crystals formulations containing them and methods of making them
    1.
    发明授权
    Stabilized protein crystals formulations containing them and methods of making them 有权
    含有它们的稳定化蛋白质晶体制剂及其制备方法

    公开(公告)号：US06541606B2

    公开(公告)日：2003-04-01

    申请号：US09374132

    申请日：1999-08-10

    申请人： Alexey L. Margolin ,  Nazar K. Khalaf ,  Nancy L. St. Clair ,  Scott L. Rakestraw ,  Bhami C. Shenoy

    发明人： Alexey L. Margolin ,  Nazar K. Khalaf ,  Nancy L. St. Clair ,  Scott L. Rakestraw ,  Bhami C. Shenoy

    IPC分类号： C07K1700

    CPC分类号： A61K9/50 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1647 ,  A61K38/27 ,  A61K39/00 ,  A61K39/395 ,  A61K47/10 ,  A61K47/26 ,  A61K47/40 ,  A61K47/42 ,  C07K14/765 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/18 ,  C12N9/84 ,  C12Y101/03004 ,  C12Y301/01003 ,  C12Y305/01011 ,  Y10S530/813 ,  Y10S530/815

    摘要： This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals. According to this invention, protein crystals or crystal formulations are encapsulated within a matrix comprising a polymeric carrier to form a composition. The formulations and compositions enhance preservation of the native biologically active tertiary structure of the proteins and create a reservoir which can slowly release active protein where and when it is needed. Methods are provided preparing stabilized formulations using pharmaceutical ingredients or excipients and optionally encapsulating them in a polymeric carrier to produce compositions and using such protein crystal formulations and compositions for biomedical applications, including delivery of therapeutic proteins and vaccines. Additional uses for the protein crystal formulations and compositions of this invention involve protein delivery in human food, agricultural feeds, veterinary compositions, diagnostics, cosmetics and personal care compositions.

    摘要翻译： 本发明涉及用于稳定，储存和递送生物活性大分子如蛋白质，肽和核酸的方法。 特别地，本发明涉及包含它们的蛋白质或核酸晶体，制剂和组合物。 提供了用于蛋白质和核酸结晶的方法以及制备用于干燥或浆液制剂的稳定的蛋白质或核酸晶体。 本发明还涉及将蛋白质，糖蛋白，酶，抗体，激素和肽晶体或晶体制剂包封到用于生物递送给人和动物的组合物中。 根据本发明，将蛋白质晶体或晶体制剂包封在包含聚合物载体的基质中以形成组合物。 制剂和组合物增强蛋白质的天然生物活性三级结构的保存，并产生可以在何时何地需要缓慢释放活性蛋白质的储库。 提供了使用药物成分或赋形剂并任选将其包封在聚合物载体中以产生组合物并使用用于生物医学应用的蛋白质晶体制剂和组合物（包括递送治疗性蛋白质和疫苗）的方法。 本发明的蛋白质晶体制剂和组合物的另外用途涉及人类食物，农业饲料，兽医成分，诊断，化妆品和个人护理组合物中的蛋白质递送。

    Stabilized protein crystals, formulations comprising them and methods of making them
    2.
    发明授权
    Stabilized protein crystals, formulations comprising them and methods of making them 有权
    稳定的蛋白质晶体，包含它们的制剂及其制备方法

    公开(公告)号：US08558048B2

    公开(公告)日：2013-10-15

    申请号：US12609650

    申请日：2009-10-30

    申请人： Alexey L. Margolin ,  Nazar K. Khalaf ,  Nancy L. St. Clair ,  Scott L. Rakestraw ,  Bhami C. Shenoy

    发明人： Alexey L. Margolin ,  Nazar K. Khalaf ,  Nancy L. St. Clair ,  Scott L. Rakestraw ,  Bhami C. Shenoy

    IPC分类号： C07C7/14 ,  C07C7/20 ,  C01C1/18

    CPC分类号： A61K9/50 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1647 ,  A61K38/27 ,  A61K39/00 ,  A61K39/395 ,  A61K47/10 ,  A61K47/26 ,  A61K47/40 ,  A61K47/42 ,  C07K14/765 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/18 ,  C12N9/84 ,  C12Y101/03004 ,  C12Y301/01003 ,  C12Y305/01011 ,  Y10S530/813 ,  Y10S530/815

    摘要： This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals. According to this invention, protein crystals or crystal formulations are encapsulated within a matrix comprising a polymeric carrier to form a composition. The formulations and compositions enhance preservation of the native biologically active tertiary structure of the proteins and create a reservoir which can slowly release active protein where and when it is needed. Methods are provided preparing stabilized formulations using pharmaceutical ingredients or excipients and optionally encapsulating them in a polymeric carrier to produce compositions and using such protein crystal formulations and compositions for biomedical applications, including delivery of therapeutic proteins and vaccines. Additional uses for-the protein crystal formulations and compositions of this invention involve protein delivery in human food, agricultural feeds, veterinary compositions, diagnostics, cosmetics and personal care compositions.

    摘要翻译： 本发明涉及用于稳定，储存和递送生物活性大分子如蛋白质，肽和核酸的方法。 特别地，本发明涉及包含它们的蛋白质或核酸晶体，制剂和组合物。 提供了用于蛋白质和核酸结晶的方法以及制备用于干燥或浆液制剂的稳定的蛋白质或核酸晶体。 本发明还涉及将蛋白质，糖蛋白，酶，抗体，激素和肽晶体或晶体制剂包封到用于生物递送给人和动物的组合物中。 根据本发明，将蛋白质晶体或晶体制剂包封在包含聚合物载体的基质中以形成组合物。 制剂和组合物增强蛋白质的天然生物活性三级结构的保存，并产生可以在何时何地需要缓慢释放活性蛋白质的储库。 提供了使用药物成分或赋形剂并任选将其包封在聚合物载体中以产生组合物并使用用于生物医学应用的蛋白质晶体制剂和组合物（包括递送治疗性蛋白质和疫苗）的方法。 用于本发明的蛋白质晶体制剂和组合物的其它用途涉及人类食物，农业饲料，兽医成分，诊断，化妆品和个人护理组合物中的蛋白质递送。

    Stabilized protein crystals, formulations comprising them and methods of making them
    3.
    发明申请
    Stabilized protein crystals, formulations comprising them and methods of making them 审中-公开
    稳定的蛋白质晶体，包含它们的制剂及其制备方法

    公开(公告)号：US20080226623A1

    公开(公告)日：2008-09-18

    申请号：US12069696

    申请日：2008-02-11

    申请人： Alexey L. Margolin ,  Nazar K. Khalaf ,  Nancy L. St. Clair ,  Scott L. Rakestraw ,  Bhami C. Shenoy

    发明人： Alexey L. Margolin ,  Nazar K. Khalaf ,  Nancy L. St. Clair ,  Scott L. Rakestraw ,  Bhami C. Shenoy

    IPC分类号： A61K39/395 ,  A61K9/48 ,  A61K38/00 ,  A61P43/00 ,  A61K38/46

    CPC分类号： A61K9/50 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1647 ,  A61K38/27 ,  A61K39/00 ,  A61K39/395 ,  A61K47/10 ,  A61K47/26 ,  A61K47/40 ,  A61K47/42 ,  C07K14/765 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/18 ,  C12N9/84 ,  C12Y101/03004 ,  C12Y301/01003 ,  C12Y305/01011 ,  Y10S530/813 ,  Y10S530/815

    摘要： This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals. According to this invention, protein crystals or crystal formulations are encapsulated within a matrix comprising a polymeric carrier to form a composition. The formulations and compositions enhance preservation of the native biologically active tertiary structure of the proteins and create a reservoir which can slowly release active protein where and when it is needed. Methods are provided preparing stabilized formulations using pharmaceutical ingredients or excipients and optionally encapsulating them in a polymeric carrier to produce compositions and using such protein crystal formulations and compositions for biomedical applications, including delivery of therapeutic proteins and vaccines. Additional uses for the protein crystal formulations and compositions of this invention involve protein delivery in human food, agricultural feeds, veterinary compositions, diagnostics, cosmetics and personal care compositions.

    摘要翻译： 本发明涉及用于稳定，储存和递送生物活性大分子如蛋白质，肽和核酸的方法。 特别地，本发明涉及包含它们的蛋白质或核酸晶体，制剂和组合物。 提供了用于蛋白质和核酸结晶的方法以及制备用于干燥或浆液制剂的稳定的蛋白质或核酸晶体。 本发明还涉及将蛋白质，糖蛋白，酶，抗体，激素和肽晶体或晶体制剂包封到用于生物递送给人和动物的组合物中。 根据本发明，将蛋白质晶体或晶体制剂包封在包含聚合物载体的基质中以形成组合物。 制剂和组合物增强蛋白质的天然生物活性三级结构的保存，并产生可以在何时何地需要缓慢释放活性蛋白质的储库。 提供了使用药物成分或赋形剂并任选将其包封在聚合物载体中以产生组合物并使用用于生物医学应用的蛋白质晶体制剂和组合物（包括递送治疗性蛋白质和疫苗）的方法。 本发明的蛋白质晶体制剂和组合物的另外用途涉及人类食物，农业饲料，兽医成分，诊断，化妆品和个人护理组合物中的蛋白质递送。

    STABILIZED PROTEIN CRYSTALS, FORMULATIONS COMPRISING THEM AND METHODS OF MAKING THEM
    4.
    发明申请
    STABILIZED PROTEIN CRYSTALS, FORMULATIONS COMPRISING THEM AND METHODS OF MAKING THEM 有权
    稳定蛋白水晶，包含它们的制剂及其制备方法

    公开(公告)号：US20100255100A1

    公开(公告)日：2010-10-07

    申请号：US12609650

    申请日：2009-10-30

    申请人： Alexey J. Margolin ,  Nazar K. Khalaf ,  Nancy L. St. Clair ,  Scott L. Rakestraw ,  Bhami C. Shenoy

    发明人： Alexey J. Margolin ,  Nazar K. Khalaf ,  Nancy L. St. Clair ,  Scott L. Rakestraw ,  Bhami C. Shenoy

    IPC分类号： A61K38/46 ,  A61K38/28 ,  A61K38/22 ,  A61K38/16 ,  A61K38/26 ,  A61K38/37 ,  A61K38/24 ,  A61K9/00 ,  A61P5/06 ,  A61P7/12 ,  A61P15/08 ,  A61P3/10

    CPC分类号： A61K9/50 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/1647 ,  A61K38/27 ,  A61K39/00 ,  A61K39/395 ,  A61K47/10 ,  A61K47/26 ,  A61K47/40 ,  A61K47/42 ,  C07K14/765 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/18 ,  C12N9/84 ,  C12Y101/03004 ,  C12Y301/01003 ,  C12Y305/01011 ,  Y10S530/813 ,  Y10S530/815

    摘要： This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and compositions comprising them. Methods are provided for the crystallization of proteins and nucleic acids and for the preparation of stabilized protein or nucleic acid crystals for use in dry or slurry formulations. The present invention is further directed to encapsulating proteins, glycoproteins, enzymes, antibodies, hormones and peptide crystals or crystal formulations into compositions for biological delivery to humans and animals. According to this invention, protein crystals or crystal formulations are encapsulated within a matrix comprising a polymeric carrier to form a composition. The formulations and compositions enhance preservation of the native biologically active tertiary structure of the proteins and create a reservoir which can slowly release active protein where and when it is needed. Methods are provided preparing stabilized formulations using pharmaceutical ingredients or excipients and optionally encapsulating them in a polymeric carrier to produce compositions and using such protein crystal formulations and compositions for biomedical applications, including delivery of therapeutic proteins and vaccines. Additional uses for-the protein crystal formulations and compositions of this invention involve protein delivery in human food, agricultural feeds, veterinary compositions, diagnostics, cosmetics and personal care compositions.

    摘要翻译： 本发明涉及用于稳定，储存和递送生物活性大分子如蛋白质，肽和核酸的方法。 特别地，本发明涉及包含它们的蛋白质或核酸晶体，制剂和组合物。 提供了用于蛋白质和核酸结晶的方法以及制备用于干燥或浆液制剂的稳定的蛋白质或核酸晶体。 本发明还涉及将蛋白质，糖蛋白，酶，抗体，激素和肽晶体或晶体制剂包封到用于生物递送给人和动物的组合物中。 根据本发明，将蛋白质晶体或晶体制剂包封在包含聚合物载体的基质中以形成组合物。 制剂和组合物增强蛋白质的天然生物活性三级结构的保存，并产生可以在何时何地需要缓慢释放活性蛋白质的储库。 提供了使用药物成分或赋形剂并任选将其包封在聚合物载体中以产生组合物并使用用于生物医学应用的蛋白质晶体制剂和组合物（包括递送治疗性蛋白质和疫苗）的方法。 用于本发明的蛋白质晶体制剂和组合物的其它用途涉及人类食物，农业饲料，兽医成分，诊断，化妆品和个人护理组合物中的蛋白质递送。