公开(公告)号：US20100262067A1

公开(公告)日：2010-10-14

申请号：US12820955

申请日：2010-06-22

Applicant: Victor I. Chornenky ,  Ali Jaafar

Inventor： Victor I. Chornenky ,  Ali Jaafar

IPC: A61N1/30 ,  A61B18/14

CPC classification number: A61B18/1492 ,  A61B18/12 ,  A61B18/1206 ,  A61B2018/00029 ,  A61B2018/00285 ,  A61B2018/00434 ,  A61B2018/00517 ,  A61B2018/00547 ,  A61B2018/00613 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/124 ,  A61N1/325

Abstract: An apparatus and a method for treatment of benign prostatic hyperplasia are disclosed. The apparatus includes an applicator piece carrying a set of electrodes shaped and positioned to create a substantial electric field in the volume of hyperplasia and a pulse generator adapted for delivery of electrical pulses above the upper electroporation limit for the neoplastic cells. The amplitude, duration and number of the electrical pulses are generally selected to cause necrosis of a significant fraction of the volume of benign prostatic hyperplasia. The apparatus may include a high frequency system for heating the prostatic tissue and a cooling system for cooling the urethra. The combined action of heating and cooling may increase the temperature of the prostate cells to 45 degrees C. to 55 degrees C., while keeping the urinary tract at a temperature 15 degrees C. to 20 degrees C. This temperature distribution can increase the selectivity of the treatment by increasing susceptibility of the neoplastic cells to the electroporation treatment and decreasing it for the normal urethral tissues.

Abstract translation: 公开了一种用于治疗良性前列腺增生的装置和方法。 该装置包括一个施加器部件，其承载一组电极，其形状和位置以在增生体积中产生实质电场，以及脉冲发生器，适于将电脉冲传送到肿瘤细胞的上部电穿孔极限以上。 通常选择电脉冲的幅度，持续时间和数量以使良性前列腺增生体积的显着部分坏死。 该装置可以包括用于加热前列腺组织的高频系统和用于冷却尿道的冷却系统。 加热和冷却的联合作用可将前列腺细胞的温度升高至45摄氏度至55摄氏度，同时将尿道保持在15摄氏度至20摄氏度的温度。该温度分布可提高选择性 通过增加肿瘤细胞对电穿孔治疗的敏感性并将其降低为正常的尿道组织来治疗。

公开(公告)号：US07130697B2

公开(公告)日：2006-10-31

申请号：US10668775

申请日：2003-09-23

Applicant: Victor I. Chornenky ,  Ali Jaafar

Inventor： Victor I. Chornenky ,  Ali Jaafar

IPC: A61F2/00 ,  A61B18/18

CPC classification number: A61N1/325 ,  A61B18/1477 ,  A61B18/1485 ,  A61B2017/00274 ,  A61B2018/00547 ,  A61B2018/1425

Abstract: An apparatus and method for treatment of benign prostatic hyperplasia is disclosed wherein the apparatus includes an applicator having a probe having proximal and distal probe sections wherein the proximal and distal probe sections each define an axis and wherein the axes are not collinear.

Abstract translation: 公开了用于治疗良性前列腺增生的装置和方法，其中所述装置包括具有探针的施用器，所述探针具有近端和远端探针部分，其中所述近端和远端探针部分各自限定轴线，并且其中所述轴线不共线。

公开(公告)号：US07086577B2

公开(公告)日：2006-08-08

申请号：US10358265

申请日：2003-02-05

Applicant: Victor I Chornenky ,  Eunsung Park ,  Graham S. Kerslick ,  Ali Jaafar ,  Mark Gailloux

Inventor： Victor I Chornenky ,  Eunsung Park ,  Graham S. Kerslick ,  Ali Jaafar ,  Mark Gailloux

IPC: B23K28/00

CPC classification number: A61N5/1001 ,  H01J35/32 ,  H01J2235/164

Abstract: An emitter for a miniature X-ray apparatus comprises an insulating shell, an anode, and a cathode. The insulating shell includes a conical brazing surface, brazed to a conical brazing surface on the anode. The braze consists of a pure titanium layer and a pure tin layer. During brazing, the pure metals react and bond to the insulating shell and create a titanium-tin alloy between the pure layers. Pure tin is sputtered from tin sputter target onto the exposed brazing surfaces of the cathode cap and the anode. The insulating shell is placed in a vacuum chamber of deposition applicator, which deposits an active metal onto the shell brazing surface. In a brazing oven, the anode is placed within insulating shell such that the anode conical brazing surface and the shell conical brazing surface are contacting and aligned with each other. During brazing, the cathode is brought into contact with the insulating shell. The sealed emitters are placed in a sputtering machine's vacuum chamber. A metal is sputtered from a sputtering target to form a metal layer on the exterior of insulating shell.

公开(公告)号：US08647338B2

公开(公告)日：2014-02-11

申请号：US13556455

申请日：2012-07-24

Applicant: Victor I. Chornenky ,  Ali Jaafar

Inventor： Victor I. Chornenky ,  Ali Jaafar

IPC: A61B18/14

CPC classification number: A61B18/14 ,  A61B18/1445 ,  A61B18/1477 ,  A61B2018/00452 ,  A61B2018/00613 ,  A61B2018/1425 ,  A61B2018/143 ,  A61N1/0412

Abstract: A method of treating a human body by destroying tissue cells is provided. The method involves positioning an electric field generating element near a target area containing tissue cells to be killed in the human body, and treating the human body by applying electrical pulses through the positioned electric field generating element in an amount above an upper limit of electroporation to irreversibly open pores in membranes of the tissue cells in the target area, thereby killing the tissue cells in the target area.

Abstract translation: 提供了通过破坏组织细胞来治疗人体的方法。 所述方法包括将电场产生元件定位在包含要在人体中被杀死的组织细胞的靶区域附近，并且通过以高于电穿孔上限的量施加电脉冲通过所述定位电场产生元件来处理人体， 在目标区域中的组织细胞的膜中不可逆地开放孔，从而杀死目标区域中的组织细胞。

公开(公告)号：US08460167B2

公开(公告)日：2013-06-11

申请号：US12878028

申请日：2010-09-08

Applicant: Victor I Chornenky ,  Ali Jaafar

Inventor： Victor I Chornenky ,  Ali Jaafar

IPC: A61N2/02

CPC classification number: A61N2/004 ,  A61N1/40 ,  A61N2/02

Abstract: A method, apparatus and a system for thermally-assisted pulsed electromagnetic field stimulation for treatment of osteoarthritis are disclosed. In one embodiment, the system comprises a multi-coil applicator adapted for positioning near or around of the treated joint, a pulse generator functionally coupled to the applicator, a power supply, and a feedback loop for stabilizing the temperature of the joint. The feedback loop includes a heating element, a temperature sensor and an electronic controller for maintaining the temperature of the joint in the range of 38 to 42 degree C. At elevated temperatures the healing effect of PEMF stimulation on the cartilage is maximized and overall efficiency of the treatment is improved. To produce a high electric field, the coils of the applicator are made with a low number of turns, for example less than 5 turns, and are spatially arranged to cover the whole joint without “dead” zones.

Abstract translation: 公开了用于治疗骨关节炎的热辅助脉冲电磁场​​刺激的方法，装置和系统。 在一个实施例中，系统包括多线圈施加器，适用于定位处理接头的近处或周围，与施加器功能耦合的脉冲发生器，电源和用于稳定接头温度的反馈回路。 反馈回路包括加热元件，温度传感器和电子控制器，用于将接头的温度保持在38至42摄氏度的范围内。在升高的温度下，PEMF刺激对软骨的愈合效果最大化，并且总体效率 治疗得到改善。 为了产生高电场，施加器的线圈被制成具有低匝数，例如小于5匝，并且在空间上布置成覆盖整个接头而没有“死区”。

公开(公告)号：US20110009860A1

公开(公告)日：2011-01-13

申请号：US12501225

申请日：2009-07-10

Applicant: Victor I. Chornenky ,  Ali Jaafar

Inventor： Victor I. Chornenky ,  Ali Jaafar

IPC: A61B18/14

CPC classification number: A61B18/14 ,  A61B18/1445 ,  A61B18/1477 ,  A61B2018/00452 ,  A61B2018/00613 ,  A61B2018/1425 ,  A61B2018/143 ,  A61N1/0412

Abstract: An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

Abstract translation: 提供了一种用于通过电穿孔代替整容手术来进行人脸和身体非侵入性治疗的装置和方法。 该装置包括高压脉冲发生器和具有两个或更多个电极的施加器，该电极与患者的皮肤紧密机械和电接触以将脉搏施加到患者皮肤。 施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。 输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。 沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。 电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

公开(公告)号：US06892099B2

公开(公告)日：2005-05-10

申请号：US09931672

申请日：2001-08-17

Applicant: Ali Jaafar ,  Victor I. Chornenky

Inventor： Ali Jaafar ,  Victor I. Chornenky

IPC: A61N1/32 ,  A61N1/34 ,  A61N1/18

CPC classification number: A61N1/325 ,  A61N1/0424 ,  A61N1/327 ,  A61N1/328 ,  A61N1/36014

Abstract: An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

Abstract translation: 提供了一种用于通过电穿孔代替整容手术来进行人脸和身体非侵入性治疗的装置和方法。 该装置包括高压脉冲发生器和具有两个或更多个电极的施加器，该电极与患者的皮肤紧密机械和电接触以将脉搏施加到患者皮肤。 施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。 输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。 沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。 电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

公开(公告)号：US06699230B2

公开(公告)日：2004-03-02

申请号：US09849051

申请日：2001-05-07

Applicant: Ali Jaafar ,  Victor I. Chornenky

Inventor： Ali Jaafar ,  Victor I. Chornenky

IPC: A61M3100

CPC classification number: A61M5/1456 ,  A61J3/002 ,  A61M5/1407 ,  A61M5/14244 ,  A61M5/1452 ,  A61M5/172 ,  A61M5/44 ,  A61M39/223 ,  A61M2005/1402 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/3606 ,  A61M2205/50 ,  A61M2205/8206

Abstract: This invention provides an apparatus and method for emergency administration or self-administration of thrombolytic therapy in early stage of a heart attack. The apparatus includes a needle injector for making a venipuncture, a battery operated micro cooler for maintaining low temperature environment for vials with lyophilized thrombolytic and adjuvant drugs, a container with a diluent for reconstitution of the lyophilized drugs, a programmable infusion pump, and a microprocessor for controlling the process of infusion and recording the data. As the system is activated, said container becomes fluidly communicable with the infusion pump and vials with drugs in the cooler. Designed for autonomous execution of several schedules of infusion, it also can be controlled remotely by a qualified operator via an Internet interface.

Abstract translation: 本发明提供了一种在心脏病发作早期进行血栓溶解治疗的应急管理或自我管理的装置和方法。 该装置包括用于制造静脉穿刺的针注射器，用于维持具有冻干溶栓剂和辅助药物的小瓶的低温环境的电池操作微冷却器，具有用于重构冻干药物的稀释剂的容器，可编程输液泵和微处理器 用于控制输液和记录数据的过程。 当系统被激活时，所述容器变得与输液泵流体连通，并将药物放在冷却器中。 专为自动执行几个输液时间表而设计，也可以由合格的操作员通过互联网接口远程控制。

公开(公告)号：US07938824B2

公开(公告)日：2011-05-10

申请号：US11106835

申请日：2005-04-15

Applicant: Victor I. Chornenky ,  Ali Jaafar

Inventor： Victor I. Chornenky ,  Ali Jaafar

IPC: A61B18/00 ,  A61N5/00 ,  C12N13/00

CPC classification number: A61N1/325 ,  A61N1/0424 ,  A61N1/327 ,  A61N1/328 ,  A61N1/36014

Abstract: An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

公开(公告)号：US20100002840A1

公开(公告)日：2010-01-07

申请号：US12337290

申请日：2008-12-17

Applicant: Ali Jaafar ,  Victor I. Chornenky

Inventor： Ali Jaafar ,  Victor I. Chornenky

IPC: H01J35/00 ,  G21F3/00

CPC classification number: H01J35/065 ,  H01J35/32

Abstract: Disclosed herein is an x-ray field emission apparatus, system and method, the apparatus having a hollow probe held at vacuum; a cathode enclosed within the probe, the cathode producing an electron stream when connected to a high negative potential; an anode enclosed within the probe and separated from the cathode by a gap, said the providing a target for the electron stream; and a shield assembly comprising a hollow shield electrode positioned within the probe and about the cathode.

Abstract translation: 本文公开了一种x射线场发射装置，系统和方法，该装置具有保持在真空下的中空探针; 封装在探针内的阴极，阴极在连接到高负电位时产生电子流; 阳极包围在探针内并与阴极隔开间隙，所述提供电子流的靶; 以及屏蔽组件，其包括位于探针内并围绕阴极的中空屏蔽电极。