公开(公告)号：US08647338B2

公开(公告)日：2014-02-11

申请号：US13556455

申请日：2012-07-24

申请人： Victor I. Chornenky ,  Ali Jaafar

发明人： Victor I. Chornenky ,  Ali Jaafar

IPC分类号： A61B18/14

CPC分类号： A61B18/14 ,  A61B18/1445 ,  A61B18/1477 ,  A61B2018/00452 ,  A61B2018/00613 ,  A61B2018/1425 ,  A61B2018/143 ,  A61N1/0412

摘要： A method of treating a human body by destroying tissue cells is provided. The method involves positioning an electric field generating element near a target area containing tissue cells to be killed in the human body, and treating the human body by applying electrical pulses through the positioned electric field generating element in an amount above an upper limit of electroporation to irreversibly open pores in membranes of the tissue cells in the target area, thereby killing the tissue cells in the target area.

摘要翻译： 提供了通过破坏组织细胞来治疗人体的方法。 所述方法包括将电场产生元件定位在包含要在人体中被杀死的组织细胞的靶区域附近，并且通过以高于电穿孔上限的量施加电脉冲通过所述定位电场产生元件来处理人体， 在目标区域中的组织细胞的膜中不可逆地开放孔，从而杀死目标区域中的组织细胞。

公开(公告)号：US08460167B2

公开(公告)日：2013-06-11

申请号：US12878028

申请日：2010-09-08

申请人： Victor I Chornenky ,  Ali Jaafar

发明人： Victor I Chornenky ,  Ali Jaafar

IPC分类号： A61N2/02

CPC分类号： A61N2/004 ,  A61N1/40 ,  A61N2/02

摘要： A method, apparatus and a system for thermally-assisted pulsed electromagnetic field stimulation for treatment of osteoarthritis are disclosed. In one embodiment, the system comprises a multi-coil applicator adapted for positioning near or around of the treated joint, a pulse generator functionally coupled to the applicator, a power supply, and a feedback loop for stabilizing the temperature of the joint. The feedback loop includes a heating element, a temperature sensor and an electronic controller for maintaining the temperature of the joint in the range of 38 to 42 degree C. At elevated temperatures the healing effect of PEMF stimulation on the cartilage is maximized and overall efficiency of the treatment is improved. To produce a high electric field, the coils of the applicator are made with a low number of turns, for example less than 5 turns, and are spatially arranged to cover the whole joint without “dead” zones.

摘要翻译： 公开了用于治疗骨关节炎的热辅助脉冲电磁场​​刺激的方法，装置和系统。 在一个实施例中，系统包括多线圈施加器，适用于定位处理接头的近处或周围，与施加器功能耦合的脉冲发生器，电源和用于稳定接头温度的反馈回路。 反馈回路包括加热元件，温度传感器和电子控制器，用于将接头的温度保持在38至42摄氏度的范围内。在升高的温度下，PEMF刺激对软骨的愈合效果最大化，并且总体效率 治疗得到改善。 为了产生高电场，施加器的线圈被制成具有低匝数，例如小于5匝，并且在空间上布置成覆盖整个接头而没有“死区”。

公开(公告)号：US20110009860A1

公开(公告)日：2011-01-13

申请号：US12501225

申请日：2009-07-10

申请人： Victor I. Chornenky ,  Ali Jaafar

发明人： Victor I. Chornenky ,  Ali Jaafar

IPC分类号： A61B18/14

CPC分类号： A61B18/14 ,  A61B18/1445 ,  A61B18/1477 ,  A61B2018/00452 ,  A61B2018/00613 ,  A61B2018/1425 ,  A61B2018/143 ,  A61N1/0412

摘要： An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

摘要翻译： 提供了一种用于通过电穿孔代替整容手术来进行人脸和身体非侵入性治疗的装置和方法。 该装置包括高压脉冲发生器和具有两个或更多个电极的施加器，该电极与患者的皮肤紧密机械和电接触以将脉搏施加到患者皮肤。 施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。 输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。 沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。 电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

公开(公告)号：US20060217703A1

公开(公告)日：2006-09-28

申请号：US11347965

申请日：2006-02-06

申请人： Victor Chornenky ,  Ali Jaafar

发明人： Victor Chornenky ,  Ali Jaafar

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B18/12 ,  A61B18/1206 ,  A61B2018/00029 ,  A61B2018/00285 ,  A61B2018/00434 ,  A61B2018/00517 ,  A61B2018/00547 ,  A61B2018/00613 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/124 ,  A61N1/325

摘要： An apparatus and a method for treatment of benign prostatic hyperplasia are disclosed. The apparatus includes an applicator piece carrying a set of electrodes shaped and positioned to create a substantial electric field in the volume of hyperplasia and a pulse generator adapted for delivery of electrical pulses above the upper electroporation limit for the neoplastic cells. The amplitude, duration and number of the electrical pulses are generally selected to cause necrosis of a significant fraction of the volume of benign prostatic hyperplasia. The apparatus may include a high frequency system for heating the prostatic tissue and a cooling system for cooling the urethra. The combined action of heating and cooling may increase the temperature of the prostate cells to 45 degrees C. to 55 degrees C., while keeping the urinary tract at a temperature 15 degrees C. to 20 degrees C. This temperature distribution can increase the selectivity of the treatment by increasing susceptibility of the neoplastic cells to the electroporation treatment and decreasing it for the normal urethral tissues.

摘要翻译： 公开了一种用于治疗良性前列腺增生的装置和方法。 该装置包括一个施加器部件，其承载一组电极，其形状和位置以在增生体积中产生实质电场，以及脉冲发生器适用于递送高于肿瘤细胞上电穿孔极限的电脉冲。 通常选择电脉冲的幅度，持续时间和数量以使良性前列腺增生体积的显着部分坏死。 该装置可以包括用于加热前列腺组织的高频系统和用于冷却尿道的冷却系统。 加热和冷却的联合作用可将前列腺细胞的温度升高至45摄氏度至55摄氏度，同时将尿道保持在15摄氏度至20摄氏度的温度。该温度分布可提高选择性 通过增加肿瘤细胞对电穿孔治疗的敏感性并将其降低为正常的尿道组织来治疗。

公开(公告)号：US20060067467A1

公开(公告)日：2006-03-30

申请号：US11236147

申请日：2005-09-27

申请人： Victor Chornenky ,  Ali Jaafar

发明人： Victor Chornenky ,  Ali Jaafar

IPC分类号： A61N5/10

CPC分类号： A61N5/1015

摘要： A system and method providing conformal x-ray brachytherapy for treatment of a body having a tumor by irradiation of a target volume of tissue in a patient is disclosed wherein an x-ray probe including an x-ray emitter, an imaging probe configured to image the target volume, a translation stage mounting the x-ray probe for translational motion, a rotation stage mounting the x-ray probe for rotational motion, a compliant balloon inserted into a cavity created in a body by excision of a tumor, and computer operatively connected to the x-ray and imaging probes and the rotation and translation stages are provided to image and control the operation of the x-ray probe to irradiate the target volume according to predetermined treatment protocols.

摘要翻译： 公开了一种提供适形X射线近距离放射疗法的系统和方法，用于通过照射患者的目标体积的组织来治疗患有肿瘤的身体，其中包括x射线发射器的X射线探针，被配置为成像的成像探针 目标体积，安装用于平移运动的x射线探针的平移台，安装用于旋转运动的x射线探针的旋转台，插入通过切除肿瘤而在体内产生的腔中的顺应性球囊，以及可操作地计算机 连接到x射线和成像探针，并且提供旋转和平移阶段以根据预定的治疗方案对X射线探针的操作进行成像和控制以照射目标体积。

公开(公告)号：US06892099B2

公开(公告)日：2005-05-10

申请号：US09931672

申请日：2001-08-17

申请人： Ali Jaafar ,  Victor I. Chornenky

发明人： Ali Jaafar ,  Victor I. Chornenky

IPC分类号： A61N1/32 ,  A61N1/34 ,  A61N1/18

CPC分类号： A61N1/325 ,  A61N1/0424 ,  A61N1/327 ,  A61N1/328 ,  A61N1/36014

摘要： An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

摘要翻译： 提供了一种用于通过电穿孔代替整容手术来进行人脸和身体非侵入性治疗的装置和方法。 该装置包括高压脉冲发生器和具有两个或更多个电极的施加器，该电极与患者的皮肤紧密机械和电接触以将脉搏施加到患者皮肤。 施加器可以由具有一个尖端的一个电极和另一个具有平坦表面的两个部件组成。 输送到电极的高电压脉冲在尖锐的电极的尖端产生足够高的电场，以通过电穿孔引起相对较大的皮下脂肪细胞的死亡。 沿着皮肤移动电极尖端产生一系列坏死的皮下脂肪细胞，其随后被身体代谢。 电极沿着面部或颈部上的预定线的多次应用产生皮肤收缩和处理区域下面的皮下脂肪体积。

公开(公告)号：US06699230B2

公开(公告)日：2004-03-02

申请号：US09849051

申请日：2001-05-07

申请人： Ali Jaafar ,  Victor I. Chornenky

发明人： Ali Jaafar ,  Victor I. Chornenky

IPC分类号： A61M3100

CPC分类号： A61M5/1456 ,  A61J3/002 ,  A61M5/1407 ,  A61M5/14244 ,  A61M5/1452 ,  A61M5/172 ,  A61M5/44 ,  A61M39/223 ,  A61M2005/1402 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/3606 ,  A61M2205/50 ,  A61M2205/8206

摘要： This invention provides an apparatus and method for emergency administration or self-administration of thrombolytic therapy in early stage of a heart attack. The apparatus includes a needle injector for making a venipuncture, a battery operated micro cooler for maintaining low temperature environment for vials with lyophilized thrombolytic and adjuvant drugs, a container with a diluent for reconstitution of the lyophilized drugs, a programmable infusion pump, and a microprocessor for controlling the process of infusion and recording the data. As the system is activated, said container becomes fluidly communicable with the infusion pump and vials with drugs in the cooler. Designed for autonomous execution of several schedules of infusion, it also can be controlled remotely by a qualified operator via an Internet interface.

摘要翻译： 本发明提供了一种在心脏病发作早期进行血栓溶解治疗的应急管理或自我管理的装置和方法。 该装置包括用于制造静脉穿刺的针注射器，用于维持具有冻干溶栓剂和辅助药物的小瓶的低温环境的电池操作微冷却器，具有用于重构冻干药物的稀释剂的容器，可编程输液泵和微处理器 用于控制输液和记录数据的过程。 当系统被激活时，所述容器变得与输液泵流体连通，并将药物放在冷却器中。 专为自动执行几个输液时间表而设计，也可以由合格的操作员通过互联网接口远程控制。

公开(公告)号：US06697670B2

公开(公告)日：2004-02-24

申请号：US10364187

申请日：2003-02-11

申请人： Victor I. Chomenky ,  Ali Jaafar

发明人： Victor I. Chomenky ,  Ali Jaafar

IPC分类号： A61N118

CPC分类号： A61N1/327 ,  A61N1/0412 ,  A61N1/0424 ,  A61N1/0456 ,  A61N1/328 ,  A61N1/36021

摘要： An apparatus and method for non-invasive treatment in lieu of cosmetic surgery is disclosed. The apparatus comprises a combination of a high and low voltage pulse generators connected to two or more electrodes placed on a treatment site of the patient's body. High voltage pulses, delivered to the electrodes, create an electric field that kills subcutaneous fat cells. Low voltage pulses, delivered to the same or individual electrodes provide transcutaneous electrical nerve stimulation (TENS), blocking the signals of discomfort or pain that may arise from the high voltage pulsing.

摘要翻译： 公开了一种用于非侵入性治疗代替整容手术的装置和方法。 该装置包括连接到放置在患者身体的治疗部位上的两个或多个电极的高电压脉冲发生器和低压脉冲发生器的组合。 输送到电极的高电压脉冲产生杀死皮下脂肪细胞的电场。 传递到相同或单独电极的低电压脉冲提供经皮电神经刺激（TENS），阻止由高压脉冲引起的不适或疼痛的信号。

公开(公告)号：US20120303020A1

公开(公告)日：2012-11-29

申请号：US13556455

申请日：2012-07-24

申请人： Victor I. CHORNENKY ,  Ali JAAFAR

发明人： Victor I. CHORNENKY ,  Ali JAAFAR

IPC分类号： A61B18/14

CPC分类号： A61B18/14 ,  A61B18/1445 ,  A61B18/1477 ,  A61B2018/00452 ,  A61B2018/00613 ,  A61B2018/1425 ,  A61B2018/143 ,  A61N1/0412

摘要： A method of treating a human body by destroying tissue cells is provided. The method involves positioning an electric field generating element near a target area containing tissue cells to be killed in the human body, and treating the human body by applying electrical pulses through the positioned electric field generating element in an amount above an upper limit of electroporation to irreversibly open pores in membranes of the tissue cells in the target area, thereby killing the tissue cells in the target area.

摘要翻译： 提供了通过破坏组织细胞来治疗人体的方法。 所述方法包括将电场产生元件定位在包含要在人体中被杀死的组织细胞的靶区域附近，并且通过以高于电穿孔上限的量施加电脉冲通过所述定位电场产生元件来处理人体， 在目标区域中的组织细胞的膜中不可逆地开放孔，从而杀死目标区域中的组织细胞。

公开(公告)号：USRE42835E1

公开(公告)日：2011-10-11

申请号：US12571974

申请日：2009-10-01

申请人： Victor Chornenky ,  Ali Jaafar

发明人： Victor Chornenky ,  Ali Jaafar

IPC分类号： A61N1/18

CPC分类号： A61N1/327 ,  A61N1/0412 ,  A61N1/0424 ,  A61N1/0456 ,  A61N1/328 ,  A61N1/36021

摘要： An apparatus and method for non-invasive treatment in lieu of cosmetic surgery is disclosed. The apparatus comprises a combination of a high and low voltage pulse generators connected to two or more electrodes placed on a treatment site of the patient's body. High voltage pulses, delivered to the electrodes, create an electric field that kills subcutaneous fat cells. Low voltage pulses, delivered to the same or individual electrodes provide transcutaneous electrical nerve stimulation (TENS), blocking the signals of discomfort or pain that may arise from the high voltage pulsing.

摘要翻译： 公开了一种用于非侵入性治疗代替整容手术的装置和方法。 该装置包括连接到放置在患者身体的治疗部位上的两个或多个电极的高电压脉冲发生器和低压脉冲发生器的组合。 输送到电极的高电压脉冲产生杀死皮下脂肪细胞的电场。 传递到相同或单独电极的低电压脉冲提供经皮电神经刺激（TENS），阻止由高压脉冲引起的不适或疼痛的信号。