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11 条记录 (耗时 0.02 秒)

    Use of Substituted 8-Perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] Pyrimidin-4-one Derivatives as Therapeutic Agents
    5.
    发明申请
    Use of Substituted 8-Perfluoroalkyl-6,7,8,9-tetrahydropyrimido[1,2-a] Pyrimidin-4-one Derivatives as Therapeutic Agents 失效
    使用取代的8-全氟烷基-6,7,8,9-四氢嘧啶并[1,2-a]嘧啶-4-酮衍生物作为治疗剂

    公开(公告)号：US20070191384A1

    公开(公告)日：2007-08-16

    申请号：US11696256

    申请日：2007-04-04

    申请人： Alistair LOCHEAD ,  Mourad SAADY ,  Franck SLOWINSKI ,  Philippe YAICHE

    发明人： Alistair LOCHEAD ,  Mourad SAADY ,  Franck SLOWINSKI ,  Philippe YAICHE

    IPC分类号： A61K31/519

    CPC分类号： A61K31/519 ,  C07D487/04

    摘要： The invention relates to use of a substituted-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as described herein for treating a variety of disease states. More specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of GSK3β, such as Pick's disease.

    摘要翻译： 本发明涉及由式（I）表示的取代嘧啶酮衍生物或其盐的用途：其中X，Y，R 1，R 2，R 3，R 4，R 5，n，p和q如本文所述用于处理多种 的疾病状态。 更具体地，本发明涉及包含所述衍生物或其盐作为活性成分的药物，其用于预防和/或治疗由GSK3β的异常活性如皮克病引起的疾病。

    USE OF 8-SUBSTITUTED-6,7,8,9-TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES
    8.
    发明申请
    USE OF 8-SUBSTITUTED-6,7,8,9-TETRAHYDROPYRIMIDO[1,2-a] PYRIMIDIN-4-ONE DERIVATIVES 失效
    使用8-取代-6,7,8,9-四氢嘧啶并[1,2-a]嘧啶-4-酮衍生物

    公开(公告)号：US20080021046A1

    公开(公告)日：2008-01-24

    申请号：US11764374

    申请日：2007-06-18

    申请人： Alistair LOCHEAD ,  Mourad SAADY ,  Franck SLOWINSKI ,  Philippe YAICHE

    发明人： Alistair LOCHEAD ,  Mourad SAADY ,  Franck SLOWINSKI ,  Philippe YAICHE

    IPC分类号： A61K31/519 ,  A61P25/00 ,  A61P35/00

    CPC分类号： A61K31/519 ,  C07D487/04

    摘要： The invention relates to use of substituted-pyrimidone derivatives represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, R4, R5, n, p and q are as defined herein. More specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by abnormal activity of GSK3β, such as Pick's disease among various other diseases as claimed herein.

    摘要翻译： 本发明涉及由式（I）表示的取代嘧啶酮衍生物或其盐的用途：其中X，Y，R 1，R 2，R 3，R 4，R 5，n，p和q如本文所定义。 更具体地，本发明涉及包含所述衍生物或其盐作为活性成分的药物，其用于预防和/或治疗由GSK3β的异常活性引起的疾病，例如各种其他疾病中的皮克病，例如 在此。