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    ARYL- AND HETEROARYLPIPERIDINECARBOXYLATE-DERIVATIVES METHODS FOR THEIR PREPARATION AND USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS
    4.
    发明申请
    ARYL- AND HETEROARYLPIPERIDINECARBOXYLATE-DERIVATIVES METHODS FOR THEIR PREPARATION AND USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS 审中-公开
    ARYL-和异二氢吡啶羧酸酯衍生物的制备方法及其作为脂肪酸氨基水解酶酶抑制剂的用途

    公开(公告)号：US20070021405A1

    公开(公告)日：2007-01-25

    申请号：US11465238

    申请日：2006-08-17

    申请人： Ahmed ABOUABDELLAH ,  Antonio ALMARIO GARCIA ,  Christian HOORNAERT ,  Patrick LARDENOIS ,  Frank MARGUET

    发明人： Ahmed ABOUABDELLAH ,  Antonio ALMARIO GARCIA ,  Christian HOORNAERT ,  Patrick LARDENOIS ,  Frank MARGUET

    IPC分类号： C07D417/02 ,  C07D413/02 ,  C07D403/02

    CPC分类号： C07D471/04 ,  C07D207/06 ,  C07D211/16 ,  C07D211/52 ,  C07D401/04 ,  C07D401/06

    摘要： The present invention comprises compounds corresponding to the general formula (I): in which m, n=1 to 3 and m+n=2 to 5; p=1 to 7; A=single bond or X, Y and/or Z; X=optionally substituted methylene; Y=C2-alkenylene, which is optionally substituted, or C2-alkynylene; Z=C3-7-cycloalkyl; R1 represents a group of aryl or heteroaryl type; R2 represents a hydrogen or fluorine atom or a hydroxyl, C1-6-alkoxy or NR8R9 group; R3 represents a hydrogen atom or a C1-6-alkyl group; R4 represents a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl or C3-7-cycloalkyl-C1-3-alkyl group; in the base form or in the form of an addition salt with an acid, of a hydrate or of a solvate. The compounds are useful in the treatment of a number of diseases and/or pathological conditions such as chronic pain, dizziness, vomiting, nausea, eating disorders, neurological and psychiatric pathologies, acute or chronic neurodegenerative diseases, epilepsy, sleep disorders, cardiovascular diseases, renal ischaemia, cancers, disorders of the immune system, allergic diseases, parasitic, viral or bacterial infectious diseases, inflammatory diseases, osteoporosis, eye conditions, pulmonary conditions, gastrointestinal diseases or urinary incontinence.

    摘要翻译： 本发明包括对应于通式（I）的化合物：其中m，n = 1至3，m + n = 2至5; p = 1〜7; A =单键或X，Y和/或Z; X =任选取代的亚甲基; Y = C 2 - 亚烯基，其任选被取代，或C 2 - 亚炔基; Z = C 3-7 - 环烷基; R 1表示芳基或杂芳基的基团; R 2表示氢或氟原子或羟基，C 1-6 - 烷氧基或NR 8 R 9 >组 R 3表示氢原子或C 1-6 - 烷基; R 4表示氢原子或C 1-6 - 烷基，C 3-7 - 环烷基或C 3-7 环烷基-C 1-3 - 烷基; 以碱的形式或与酸的加成盐，水合物或溶剂化物的形式。 这些化合物可用于治疗许多疾病和/或病理状况，例如慢性疼痛，头晕，呕吐，恶心，进食障碍，神经和精神病理学，急性或慢性神经变性疾病，癫痫症，睡眠障碍，心血管疾病， 肾缺血，癌症，免疫系统疾病，过敏性疾病，寄生虫，病毒或细菌感染性疾病，炎性疾病，骨质疏松症，眼睛条件，肺部疾病，胃肠道疾病或尿失禁。