公开(公告)号：US09790207B2

公开(公告)日：2017-10-17

申请号：US14845333

申请日：2015-09-04

申请人： Alexandre Vasilievich Ivachtchenko ,  Andrey Alexandrovich Ivashchenko ,  Nikolay Filippovich Savchuk ,  ALLA CHEM, LLC

发明人： Alexandre Vasilievich Ivachtchenko ,  Oleg Dmitrievich Mitkin

IPC分类号： C07D403/14 ,  A61K31/4178 ,  A61K31/496 ,  C07D401/14 ,  A61K31/4439 ,  A61K45/06 ,  A61K38/21 ,  A61K31/7056 ,  A61K38/48 ,  A61K31/427

CPC分类号： C07D403/14 ,  A61K9/0019 ,  A61K9/2018 ,  A61K9/2059 ,  A61K9/4858 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/7056 ,  A61K38/21 ,  A61K38/482 ,  A61K45/06 ,  A61K47/10 ,  C07D401/14 ,  C12Y304/21

摘要： Compound represented by formula 1: or a pharmaceutically acceptable salt, a hydrate, a crystalline form, or a stereoisomer thereof, wherein: R1 is hydrogen, tert-butoxycarbonyl, where R11 is an optionally substituted C1-C6 alkyl, an optionally substituted C3-C6 cycloalkyl, or an optionally substituted C1-C6 alkyloxy, and arrows (←) indicate the position of substituents attachment; R2 is hydrogen, halogen, or C1-C4alkyl; R3 is an optionally substituted aryl, an optionally substituted aryloxy, an optionally substituted arylsulfanyl, an optionally substituted arylamino, or an optionally substituted nitrogen hetaryl; where R41 is an optionally substituted C1-C6 alkyl, an optionally substituted C3-C6 cycloalkyl, or an optionally substituted C1-C6 alkyloxy; X is buta-1,3-diynylene or 1,4-phenylene; arrows (←) indicate the position of substituents attachment.

公开(公告)号：US20170066746A1

公开(公告)日：2017-03-09

申请号：US14845333

申请日：2015-09-04

申请人： Alexandre Vasilievich Ivachtchenko ,  Andrey Alexandrovich Ivashchenko ,  Nikolay Filippovich Savchuk ,  ALLA CHEM, LLC

发明人： Alexandre Vasilievich Ivachtchenko ,  Oleg Dmitrievich Mitkin

IPC分类号： C07D403/14 ,  A61K31/496 ,  C07D401/14 ,  A61K31/427 ,  A61K45/06 ,  A61K38/21 ,  A61K31/7056 ,  A61K38/48 ,  A61K31/4178 ,  A61K31/4439

CPC分类号： C07D403/14 ,  A61K9/0019 ,  A61K9/2018 ,  A61K9/2059 ,  A61K9/4858 ,  A61K31/4178 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/7056 ,  A61K38/21 ,  A61K38/482 ,  A61K45/06 ,  A61K47/10 ,  C07D401/14 ,  C12Y304/21

摘要： Compound represented by formula 1: or a pharmaceutically acceptable salt, a hydrate, a crystalline form, or a stereoisomer thereof, wherein: R1 is hydrogen, tert-butoxycarbonyl, where R11 is an optionally substituted C1-C6 alkyl, an optionally substituted C3-C6 cycloalkyl, or an optionally substituted C1-C6 alkyloxy, and arrows (←) indicate the position of substituents attachment; R2 is hydrogen, halogen, or C1-C4alkyl; R3 is an optionally substituted aryl, an optionally substituted aryloxy, an optionally substituted arylsulfanyl, an optionally substituted arylamino, or an optionally substituted nitrogen hetaryl; where R41 is an optionally substituted C1-C6 alkyl, an optionally substituted C3-C6 cycloalkyl, or an optionally substituted C1-C6 alkyloxy; X is buta-1,3-diynylene or 1,4-phenylene; arrows (←) indicate the position of substituents attachment.

摘要翻译： 由式1表示的化合物或其药学上可接受的盐，水合物，结晶形式或立体异构体，其中：其中R11是任选取代的C 1 -C 6烷基，任选取代的C 3 -C 6环烷基或任选取代的C 1 -C 6烷氧基，箭头（< - ）表示取代基连接的位置; R2是氢，卤素或C1-C4烷基; R 3是任选取代的芳基，任选取代的芳氧基，任选取代的芳基硫烷基，任选取代的芳基氨基或任选取代的氮杂芳基; 其中R 41是任选取代的C 1 -C 6烷基，任选取代的C 3 -C 6环烷基或任选取代的C 1 -C 6烷氧基; X是丁-1,3-二亚炔基或1,4-亚苯基; 箭头（< - ）表示取代基连接的位置。

公开(公告)号：US20240238260A1

公开(公告)日：2024-07-18

申请号：US16767155

申请日：2020-03-27

申请人： Alena Alexandrovna Ivachtchenko ,  Nikolay Filippovich Savchuk ,  ALLA CHEM, LLC

发明人： Alexandre Vasilievich Ivachtchenko ,  Andrey Alexandrovich Ivashchenko

IPC分类号： A61K31/437 ,  A61P25/22 ,  A61P25/24 ,  C07D471/04

CPC分类号： A61K31/437 ,  A61P25/22 ,  A61P25/24 ,  C07D471/04

摘要： The present invention relates to a novel Noradrenergic and Specific Serotonergic Anxiolytic and Antidepressant (NaSSA) and a method for the production and use thereof for treating mental disorders.
The subject of this invention is a novel noradrenergic and specific serotonergic drug for the treatment of mental disorders in humans, which is 2,8-dimethyl-5-(2-phenylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride (A·HCl), a polymorphous modification thereof, and methods for the production and use thereof.

公开(公告)号：US10683315B2

公开(公告)日：2020-06-16

申请号：US15744094

申请日：2017-04-07

申请人： Alexandre Vasilievich Ivachtchenko ,  Andrey Alexandrovich Ivashchenko ,  Nikolay Filippovich Savchuk ,  ALLA CHEM, LLC ,  Alena Alexandrovna Ivachtchenko

发明人： Alexandre Vasilievich Ivachtchenko ,  Oleg Dmitrievich Mitkin

IPC分类号： A61P31/14 ,  C07F9/6558

摘要： The present invention relates to a prodrug and application thereof for the treatment of hepatitis C virus in patients.The prodrug of general formula 1, its stereoisomer, isotopically enriched analog, or crystalline or polymorphic form,

公开(公告)号：US20190054109A1

公开(公告)日：2019-02-21

申请号：US15745152

申请日：2017-04-07

申请人： Alexandre Vasilievich Ivachtchenko ,  Andrey Alexandrovich Ivashchenko ,  Nikolay Filippovich Savchuk ,  Alena Alexandrovna Ivachtchenko ,  Alexandre Vasilievich IVACHTCHENKO ,  ALLA CHEM, LLC

发明人： Alexandre Vasilievich Ivachtchenko ,  Oleg Dmitrievich Mitkin

IPC分类号： A61K31/7072 ,  A61P31/14 ,  A61K45/06 ,  A61K31/403 ,  A61K31/4709

摘要： The present invention relates to an antiviral composition and a method for application thereof in the treatment of hepatitis C virus.Said antiviral composition comprises the HCV NS5B inhibitor of general formula 1, or a stereoisomer, an isotopically enriched analog, or crystalline or polycrystalline forms thereof.

公开(公告)号：US08889701B1

公开(公告)日：2014-11-18

申请号：US14051464

申请日：2013-10-11

申请人： Alla Chem, LLC

发明人： Alexandre Vasilievich Ivachtchenko ,  Andrey Alexandrovich Ivashchenko ,  Oleg Dmitrievich Mitkin

IPC分类号： A01N43/54 ,  A61K31/505 ,  A61K45/06 ,  C07F9/6558 ,  A61K31/695 ,  A61K31/675

CPC分类号： C07F9/65586 ,  A61K31/665 ,  A61K31/675 ,  A61K31/695 ,  A61K31/7068 ,  A61K31/7072 ,  A61K45/06 ,  C07H19/067 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/393 ,  A61K2300/00

摘要： The instant invention relates to a novel compound representing a substituted phosphoramidic acid—a (2R,3R,5R)-3-hydroxy-(5-pyrimidin-1-yl)tetrahydrofuran-2-yl)methyl aryl phosphoramidate of formula 1 or a (S)-(2R,3R,5R)-3-hydroxy-(5-pyrimidin-1-yl)tetrahydrofuran-2-yl)methyl aryl phosphoramidate of formula 2, or a pharmaceutically acceptable salt, a hydrate, a crystalline form or a stereoisomer thereof, as defined in the specification.The novel compound is used for a pharmaceutical composition with at least one pharmaceutically acceptable excipient as well as with an inosine 5 monophosphate dehydrogenase inhibitor, HCV protease NS3 inhibitor, HCV protease NS3/4A inhibitor, and RNA polymerase NS5A inhibitor. The novel compound is useful as a viral polymerase HCV NS5B inhibitor and can be used for treating a disease caused by hepatitis C virus (HCV).

摘要翻译： 本发明涉及表示式1的取代的氨基磷酸-a（2R，3R，5R）-3-羟基 - （5-嘧啶-1-基）四氢呋喃-2-基）甲基芳基氨基磷酸酯的新化合物或 （2）的（S） - （2R，3R，5R）-3-羟基 - （5-嘧啶-1-基）四氢呋喃-2-基）甲基芳基氨基磷酸酯，或其药学上可接受的盐，水合物， 或其立体异构体，如说明书中所定义。 该新化合物用于具有至少一种药学上可接受的赋形剂以及肌苷5单磷酸脱氢酶抑制剂，HCV蛋白酶NS3抑制剂，HCV蛋白酶NS3 / 4A抑制剂和RNA聚合酶NS5A抑制剂的药物组合物。 该新型化合物可用作病毒聚合酶HCV NS5B抑制剂，可用于治疗丙型肝炎病毒（HCV）引起的疾病。

公开(公告)号：US20200206248A1

公开(公告)日：2020-07-02

申请号：US16615831

申请日：2018-02-14

申请人： Alena Alexandrovna Ivachtchenko ,  ALLA CHEM, LLC

发明人： Alexandre Vasilievich Ivachtchenko ,  Andrey Alexandrovich Ivashchenko ,  Nikolay Filippovich Savchuk

IPC分类号： A61K31/63 ,  A61K31/513 ,  A61K31/675 ,  A61K9/20 ,  A61P31/18 ,  A61P31/22

摘要： The present invention relates to a novel combination drug in a solid oral dosage form comprising, as one of the three active ingredients, elsulfavirine sodium that may be suitable for medical use when treating viral infections including HIV and HBV.An antiviral combination drug in a solid oral dosage form comprising, as one of the three active ingredients, a therapeutically effective amount of elsulfavirine sodium of formula 1a in a crystalline or polycrystalline form optionally in combination with auxiliary agents:

公开(公告)号：US09370576B2

公开(公告)日：2016-06-21

申请号：US14410584

申请日：2013-07-05

申请人： Alexandre Vasilievich Ivachtchenko ,  ALLA CHEM, LLC

发明人： Alexandre Vasilievich Ivachtchenko ,  Alexandre Viktorovich Demin

IPC分类号： A61K47/36 ,  A61K47/32 ,  A61K47/10 ,  A61K31/135 ,  A61K9/48 ,  A61J3/07

CPC分类号： A61K47/36 ,  A61J3/074 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/135 ,  A61K47/10 ,  A61K47/32

摘要： The invention relates to the field of pharmaceutics, in particular, to solid pharmaceutical composition comprising 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or pharmaceutically acceptable salt thereof, stabilizer, lubricant and filler; to method for preparation of pharmaceutical composition, to medicaments for immune suppression and treating multiple sclerosis. 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol represents an immune modulator, which causes redistribution of lymphocytes from blood flow into secondary lymphoid tissue that leads to immune suppression. The invention provides uniform distribution of the active ingredient in the solid composition, high stability and improved flowability of the solid pharmaceutical composition. Due to the improved flowability the compositions suggested in the invention can be used on automated equipment.

摘要翻译： 本发明涉及药物领域，特别涉及包含2-氨基-2- [2-（4-辛基苯基）乙基]丙烷-1,3-二醇或其药学上可接受的盐，稳定剂，润滑剂和 填料; 制备药物组合物的方法，用于免疫抑制和治疗多发性硬化症的药物。 2-氨基-2- [2-（4-辛基苯基）乙基]丙烷-1,3-二醇代表免疫调节剂，其引起淋巴细胞从血流重新分布到次级淋巴组织中，导致免疫抑制。 本发明提供固体组合物中活性成分的均匀分布，固体药物组合物的高稳定性和改善的流动性。 由于改进的流动性，本发明中提出的组合物可用于自动化设备。

公开(公告)号：US20150335754A1

公开(公告)日：2015-11-26

申请号：US14410584

申请日：2013-07-05

申请人： Alexandre Vasilievich Ivachtchenko ,  ALLA CHEM, LLC

发明人： Alexandre Vasilievich Ivachtchenko ,  Alexandra Viklorovich Demin

IPC分类号： A61K47/36 ,  A61K47/10 ,  A61K47/32 ,  A61K31/135

CPC分类号： A61K47/36 ,  A61J3/074 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/135 ,  A61K47/10 ,  A61K47/32

摘要： The invention relates to the field of pharmaceutics, in particular, to solid pharmaceutical composition comprising 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol or pharmaceutically acceptable salt thereof, stabilizer, lubricant and filler; to method for preparation of pharmaceutical composition, to medicaments for immune suppression and treating multiple sclerosis. 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol represents an immune modulator, which causes redistribution of lymphocytes from blood flow into secondary lymphoid tissue that leads to immune suppression. The invention provides uniform distribution of the active ingredient in the solid composition, high stability and improved flowability of the solid pharmaceutical composition. Due to the improved flowability the compositions suggested in the invention can be used on automated equipment.

摘要翻译： 本发明涉及药物领域，特别涉及包含2-氨基-2- [2-（4-辛基苯基）乙基]丙烷-1,3-二醇或其药学上可接受的盐，稳定剂，润滑剂和 填料; 制备药物组合物的方法，用于免疫抑制和治疗多发性硬化症的药物。 2-氨基-2- [2-（4-辛基苯基）乙基]丙烷-1,3-二醇代表免疫调节剂，其引起淋巴细胞从血流重新分布到次级淋巴组织中，导致免疫抑制。 本发明提供固体组合物中活性成分的均匀分布，固体药物组合物的高稳定性和改进的流动性。 由于改进的流动性，本发明中提出的组合物可用于自动化设备。