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1.发明申请Agents which regulate, inhibit, or modulate the activity and/or expression of lysyl oxidase (LOX) and LOX-like proteases as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies 审中-公开调节，抑制或调节赖氨酰氧化酶（LOX）和LOX样蛋白酶的活性和/或表达的作为降低眼内压和治疗青光眼性视网膜病变/视神经病的独特手段的药剂公开(公告)号：US20060134172A1
公开(公告)日：2006-06-22
申请号：US11293924
申请日：2005-12-05
申请人： Allan Shepard , Abbot Clark , Mark Hellberg
发明人： Allan Shepard , Abbot Clark , Mark Hellberg
IPC分类号： A61F2/00
CPC分类号： A61K31/135 , A61F9/0008 , A61K31/275 , A61K31/381
摘要： The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one non-nucleotide or non-protein agent that inhibits expression and/or signaling of lysyl oxidase (LOX) or a lysyl oxidase-like protease (LOXL).
摘要翻译： 本发明提供了一种通过施用治疗有效量的至少一种抑制赖氨酰氧化酶（LOX）的表达和/或信号传递的非核苷酸或非蛋白质试剂来降低眼内压并向有需要的患者提供神经保护作用的方法， 或赖氨酰氧化酶样蛋白酶（LOXL）。
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2.发明申请C3-Convertase Inhibitors for the Prevention and Treatment of Age-Related Macular Degeneration in Patients With At Risk Variants Of Complement Factor H 审中-公开用于预防和治疗患有年龄相关性黄斑变性的C3-转化酶抑制剂在患有风险变异的补体因子H公开(公告)号：US20070149616A1
公开(公告)日：2007-06-28
申请号：US11614595
申请日：2006-12-21
申请人： Abbot Clark , Allan Shepard
发明人： Abbot Clark , Allan Shepard
IPC分类号： A61K31/235 , C12Q1/68
CPC分类号： C12Q1/6883 , A61K31/215 , C12Q2600/106 , C12Q2600/156
摘要： The present invention provides methods for identifying a patient at risk for developing AMD by identifying the presence of the Y402H polymorphism or other at risk variants in the complement factor H gene. The present invention further provides methods for treating persons having AMD or at risk for developing AMD as a result of having the Y402H polymorphism or other at risk variants in the complement factor H gene.
摘要翻译： 本发明提供了通过鉴定补体H基因中存在Y402H多态性或其它风险变体的方法来鉴定患有发展AMD风险的患者的方法。 本发明进一步提供了治疗患有AMD的患者或由于在补体H基因中具有Y402H多态性或其他风险变异体而发展为AMD的风险的患者的方法。
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公开(公告)号：US20060172965A1
公开(公告)日：2006-08-03
申请号：US11345361
申请日：2006-02-01
申请人： Allan Shepard , Jon Chatterton , Abbot Clark , Martin Wax
发明人： Allan Shepard , Jon Chatterton , Abbot Clark , Martin Wax
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12Y301/01007 , C12Y306/03009 , C12Y402/01001
摘要： RNA interference is provided for inhibition of ocular hypertension target mRNA expression for lowering elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Ocular hypertension targets include carbonic anhydrase II, IV, and XII; β1- and β2 adrenergic receptors; acetylcholinesterase; Na+/K+-ATPase; and Na—K-2Cl cotransporter. Ocular hypertension is treated by administering interfering RNAs of the present invention.
摘要翻译： 提供RNA干扰用于抑制眼高血压靶mRNA表达，以降低开角型青光眼或高眼压患者眼内压升高。 眼睛高血压指标包括碳酸酐酶II，IV和XII; β1-和β2肾上腺素能受体; 乙酰胆碱酯酶; Na + + / K + + -ATP酶; 和Na-K-2Cl共转运蛋白。 通过施用本发明的干扰RNA来治疗眼高血压。
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4.发明申请Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (ctgf) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies 失效调节，抑制或调节结缔组织生长因子（ctgf）的活性和/或表达的作为降低眼内压和治疗青光眼性视网膜病变/视神经病的独特手段的药剂公开(公告)号：US20050234075A1
公开(公告)日：2005-10-20
申请号：US10510585
申请日：2003-04-18
申请人： Debra Fleenor , Allan Shepard , Nasreen Jacobson , Iok-Hou Pang , Abbot Clark
发明人： Debra Fleenor , Allan Shepard , Nasreen Jacobson , Iok-Hou Pang , Abbot Clark
IPC分类号： A61F9/007 , A61K31/00 , A61K31/202 , A61K31/404 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/519 , A61K31/52 , A61K45/00 , A61P27/02 , A61P27/06 , C12N9/99
CPC分类号： A61K31/4439 , A61K31/202 , A61K31/426 , A61K31/427 , A61K31/519 , A61K31/52
摘要： The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one non-nucleotide or non-protein agent that inhibits expression and/or signaling of connective tissue growth factor (CTGF).
摘要翻译： 本发明提供了一种通过施用治疗有效量的至少一种抑制结缔组织生长因子的表达和/或信号转导的非核苷酸或非蛋白质试剂来降低眼内压并向有需要的患者提供神经保护作用的方法 CTGF）。
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公开(公告)号：US20060020001A1
公开(公告)日：2006-01-26
申请号：US10537052
申请日：2003-12-19
申请人： Allan Shepard , Abbot Clark , Nasreen Jacobson
发明人： Allan Shepard , Abbot Clark , Nasreen Jacobson
IPC分类号： A61K31/426
CPC分类号： A61K31/426 , A61K31/165
摘要： Compositions containing inhibitors of cathepsin K (CTSK) expression and/or activity are provided. Methods for the treatment of glaucoma using the compositions of the invention are further provided.
摘要翻译： 提供含有组织蛋白酶K（CTSK）表达和/或活性抑制剂的组合物。 进一步提供使用本发明组合物治疗青光眼的方法。
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6.发明申请Use of agents which inhibit connective tissue growth factor (CTGF) binding and signaling via the TrkA/p75NTR receptor complex for the prevention and treatment of CTGF-mediated ocular disorders 审中-公开使用通过TrkA / p75NTR受体复合物抑制结缔组织生长因子（CTGF）结合和信号传导的药物，用于预防和治疗CTGF介导的眼部疾病公开(公告)号：US20060275797A1
公开(公告)日：2006-12-07
申请号：US11384638
申请日：2006-03-20
申请人： Allan Shepard , Nasreen Jacobson , Abbot Clark
发明人： Allan Shepard , Nasreen Jacobson , Abbot Clark
CPC分类号： A61K31/553 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N2500/00
摘要： The present invention provides a method for lowering intraocular pressure and providing neuroprotection to a patient in need thereof by administering a therapeutically effective amount of at least one agent that inhibits binding and/or signaling of connective tissue growth factor (CTGF) via the TrkA/p75NTR receptor complex.
摘要翻译： 本发明提供了一种通过施用治疗有效量的至少一种通过TrkA / p75抑制结缔组织生长因子（CTGF）的结合和/或信号传导的药物来降低眼内压并向有需要的患者提供神经保护作用的方法。 NTR 受体复合物。
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公开(公告)号：US20060172963A1
公开(公告)日：2006-08-03
申请号：US11344702
申请日：2006-02-01
申请人： Allan Shepard , Jon Chatterton , Abbot Clark
发明人： Allan Shepard , Jon Chatterton , Abbot Clark
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12Y301/01007 , C12Y306/03009 , C12Y402/01001
摘要： RNA interference is provided for inhibition of ocular hypertension target mRNA expression for lowering elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Ocular hypertension targets include carbonic anhydrase II, IV, and XII; β1- and β2 adrenergic receptors; acetylcholinesterase; Na+/K+-ATPase; and Na—K-2Cl cotransporter. Ocular hypertension is treated by administering interfering RNAs of the present invention.
摘要翻译： 提供RNA干扰用于抑制眼高血压靶mRNA表达，以降低开角型青光眼或高眼压患者眼内压升高。 眼睛高血压指标包括碳酸酐酶II，IV和XII; β1-和β2肾上腺素能受体; 乙酰胆碱酯酶; Na + + / K + + -ATP酶; 和Na-K-2Cl共转运蛋白。 通过施用本发明的干扰RNA来治疗眼高血压。
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8.发明申请Short form c-Maf transcription factor antagonists for treatment of glaucoma 审中-公开用于治疗青光眼的短型c-Maf转录因子拮抗剂公开(公告)号：US20050159432A1
公开(公告)日：2005-07-21
申请号：US11018283
申请日：2004-12-21
申请人： Allan Shepard , Nasreen Jacobson , Abbot Clark
发明人： Allan Shepard , Nasreen Jacobson , Abbot Clark
IPC分类号： A61K31/00 , A61K31/52 , A61K31/522
摘要： The short form version of c-Maf transcription factor is up-regulated in steroid-treated and transforming growth factor beta2-treated trabecular meshwork cells, and is present at elevated levels in glaucomatous versus normal trabecular meshwork cells and in glaucomatous versus normal optic nerve head tissue. Expression of short form c-Maf transcription factor under these conditions indicates a causal or effector role for the factor in primary open-angle and steroid-induced glaucoma pathogenesis. Antagonism of short form c-Maf transcription factor expression and/or activity in the trabecular meshwork or other ocular tissue is provided for inhibiting or alleviating glaucoma pathogenesis. Antagonists include cyclin-dependent kinase 2 inhibitors.
摘要翻译： c-Maf转录因子的短版本在类固醇治疗和转化生长因子β2处理的小梁细胞中上调，并且在青光眼与正常小梁网细胞和青光眼相对于正常视神经头的升高水平存在 组织。 在这些条件下，短型c-Maf转录因子的表达表明该因子在原发性开放角和类固醇诱发的青光眼发病机制中的因果或效应器作用。 提供短小型c-Maf转录因子表达和/或小梁网或其他眼组织中的活性的拮抗作用，用于抑制或减轻青光眼发病。 拮抗剂包括细胞周期蛋白依赖性激酶2抑制剂。
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公开(公告)号：US20060154981A1
公开(公告)日：2006-07-13
申请号：US11330634
申请日：2006-01-12
申请人： Peter Klimko , Mark Hellberg , Wan-Heng Wang , Abbot Clark , Loretta McNatt
发明人： Peter Klimko , Mark Hellberg , Wan-Heng Wang , Abbot Clark , Loretta McNatt
IPC分类号： A61K31/366 , A61K31/22 , A61K31/19
CPC分类号： A61K31/19 , A61K31/22 , A61K31/366
摘要： The use of 5,6,7-trihydroxyheptanoic acid and analogs for the treatment of ocular hypertension and glaucoma is disclosed.
摘要翻译： 公开了5,6,7-三羟基庚酸及其类似物用于治疗高眼压症和青光眼的用途。
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10.发明申请USE OF NON-FEMINIZING ESTROGENS AS RETINOPROTECTIVE AGENTS FOR THE TREATMENT OF GLAUCOMA 失效使用非有限化雌激素作为治疗GLAUCOMA的转基因保护剂公开(公告)号：US20070225263A1
公开(公告)日：2007-09-27
申请号：US11754710
申请日：2007-05-29
申请人： Iok-Hou Pang , Abbot Clark
发明人： Iok-Hou Pang , Abbot Clark
IPC分类号： A61K31/56
CPC分类号： A61K31/56
摘要： The invention provides pharmaceutical compositions containing non-feminizing estrogen and methods of using these compositions to prevent or ameliorate retinal and optic nerve damage associated with glaucoma.
摘要翻译： 本发明提供含有非女性化雌激素的药物组合物和使用这些组合物以预防或改善与青光眼相关的视网膜和视神经损伤的方法。
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