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公开(公告)号：US07962208B2
公开(公告)日：2011-06-14
申请号：US11113828
申请日：2005-04-25
申请人： Allan Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
发明人： Allan Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
IPC分类号： A61N1/08
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.
摘要翻译： 应用心脏保护起搏来预防或减少与血管重建手术期间血管闭塞的缺血事件相关的心律失常和/或发生的心律不齐。 起搏脉冲从起搏器产生，并通过一个或多个起搏电极产生，并通过并入到血运重建术中使用的经皮腔内血管介入（PTVI）装置上。 起搏器根据在缺血事件之前，期间和/或之后的预定心脏保护起搏序列产生起搏脉冲。
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公开(公告)号：US20110230928A1
公开(公告)日：2011-09-22
申请号：US13113706
申请日：2011-05-23
申请人： Allan Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
发明人： Allan Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.
摘要翻译： 应用心脏保护起搏来预防或减少与血管重建手术期间血管闭塞的缺血事件相关的心律失常和/或发生的心律不齐。 起搏脉冲从起搏器产生，并通过一个或多个起搏电极产生，并通过并入到血运重建术中使用的经皮腔内血管介入（PTVI）装置上。 起搏器根据在缺血事件之前，期间和/或之后的预定心脏保护起搏序列产生起搏脉冲。
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公开(公告)号：US08452400B2
公开(公告)日：2013-05-28
申请号：US13113706
申请日：2011-05-23
申请人： Allan C. Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
发明人： Allan C. Shuros , Tamara Colette Baynham , Jihong Qu , Joseph M. Pastore , Andrew P. Kramer , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
IPC分类号： A61N1/06
CPC分类号： A61N1/362 , A61B17/22 , A61B18/1492 , A61B2017/22001 , A61B2018/00214 , A61B2018/0041 , A61B2018/00422 , A61N1/056 , A61N1/3625 , A61N5/1001 , A61N2001/0585
摘要： Cardiac protection pacing is applied to prevent or reduce cardiac injury and/or occurrences of arrhythmia associated with an ischemic event including the occlusion of a blood vessel during a revascularization procedure. Pacing pulses are generated from a pacemaker and delivered through one or more pacing electrodes incorporated onto a percutaneous transluminal vascular intervention (PTVI) device used in the revascularization procedure. The pacemaker generates the pacing pulses according to a predetermined cardiac protection pacing sequence before, during, and/or after the ischemic event.
摘要翻译： 应用心脏保护起搏来预防或减少与血管重建手术期间血管闭塞的缺血事件相关的心律失常和/或发生的心律不齐。 起搏脉冲从起搏器产生，并通过一个或多个起搏电极产生，并通过并入到血运重建术中使用的经皮腔内血管介入（PTVI）装置上。 起搏器根据在缺血事件之前，期间和/或之后的预定心脏保护起搏序列产生起搏脉冲。
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4.发明申请公开(公告)号：US20090143835A1
公开(公告)日：2009-06-04
申请号：US12322382
申请日：2009-02-02
申请人： Joseph M. Pastore , Andrew P. Kramer , Julio C. Spinelli , Rodney W. Salo , Tamara Colette Baynham , Jeffrey Ross , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
发明人： Joseph M. Pastore , Andrew P. Kramer , Julio C. Spinelli , Rodney W. Salo , Tamara Colette Baynham , Jeffrey Ross , Frits W. Prinzen , Ward Y. R. Vanagt , Richard N. Cornelussen
IPC分类号： A61N1/365
CPC分类号： A61N1/056 , A61N1/3627 , A61N1/36557 , A61N1/37205 , A61N1/3787 , A61N2001/0585
摘要： An implantable cardiac protection pacing system delivers pacing pulses to protect the heart from injuries associated with ischemia and myocardial infarction. The system includes an implantable pulse generator (PG) that delivers the pacing pulses and a coronary stent electrically connected to the implantable PG to function as a pacing electrode through which the pacing pulses are delivered. In one embodiment, an intravascular lead provides the electrical connection between the coronary stent and the implantable PG to allow the implantable PG to be implanted in the femoral region. In another embodiment, the coronary stent and the implantable PG are integrated into an intravascular pulse generator-stent.
摘要翻译： 可植入心脏保护起搏系统提供起搏脉冲，以保护心脏免受与缺血和心肌梗塞相关的损伤。 该系统包括输送起搏脉冲的可植入脉冲发生器（PG）和电连接到可植入PG的冠状动脉支架，起到起搏电极的作用，起搏电极通过该起搏电极被输送。 在一个实施例中，血管内引线提供冠状支架和可植入PG之间的电连接，以允许将可植入PG植入股骨区域。 在另一个实施例中，冠状动脉支架和可植入PG集成到血管内脉冲发生器 - 支架中。
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公开(公告)号：US07437191B2
公开(公告)日：2008-10-14
申请号：US11458286
申请日：2006-07-18
申请人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. R. Vanagt
发明人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. R. Vanagt
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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公开(公告)号：US20090043348A1
公开(公告)日：2009-02-12
申请号：US12250868
申请日：2008-10-14
申请人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y.R. Vanagt
发明人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y.R. Vanagt
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of lo depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。 保护作用通过将心脏起搏装置配置为间歇地从正常操作模式切换到应变增强模式而产生，其中，lo去极化的空间模式被改变，从而使心室心肌的特定区域或区域增加机械应力 。
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公开(公告)号：US08214040B2
公开(公告)日：2012-07-03
申请号：US12250868
申请日：2008-10-14
申请人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. Vanagt
发明人： Joseph M. Pastore , Julio C. Spinelli , Frits W. Prinzen , Richard N. Cornelussen , Ward Y. Vanagt
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： A device and method for delivering electrical stimulation to the heart in a manner which provides a protective effect is disclosed. The protective effect is produced by configuring a cardiac pacing device to intermittently switch from a normal operating mode to a stress augmentation mode in which the spatial pattern of depolarization is varied to thereby subject a particular region or regions of the ventricular myocardium to increased mechanical stress.
摘要翻译： 公开了以提供保护作用的方式向心脏递送电刺激的装置和方法。 通过将心脏起搏装置配置为间歇地从正常操作模式切换到应力增强模式，其中去极化的空间模式改变从而使心室心肌的特定区域或区域增加机械应力，从而产生保护作用。
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8.发明申请METHOD AND APPARATUS FOR DEVICE CONTROLLED GENE EXPRESSION FOR CARDIAC PROTECTION 失效用于设备控制的基因表达用于心脏保护的方法和装置公开(公告)号：US20100274306A1
公开(公告)日：2010-10-28
申请号：US12830534
申请日：2010-07-06
申请人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
CPC分类号： A61N1/3627 , A61K48/0083 , A61N1/36514
摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.
摘要翻译： 基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。 生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。 在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。 基因调控信号直接或间接调控基因产物的基因表达。
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公开(公告)号：US20100145401A1
公开(公告)日：2010-06-10
申请号：US12703382
申请日：2010-02-10
申请人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
发明人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61N1/362
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译： 各种系统实施例包括神经刺激器，脉冲发生器和控制器。 神经刺激器适于产生神经刺激信号。 脉冲发生器适用于产生起搏信号以提供心肌起搏。 控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。 调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。 本文提供了其它方面和实施例。
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10.发明授权公开(公告)号：US08731677B2
公开(公告)日：2014-05-20
申请号：US12703382
申请日：2010-02-10
申请人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
发明人： Joseph M. Pastore , Tamara Colette Baynham , Andrew P. Kramer , Julio C. Spinelli , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3627 , A61N1/37211 , A61N1/3956
摘要： Various system embodiments comprise a neural stimulator, a pulse generator, and a controller. The neural stimulator is adapted to generate a neural stimulation signal. The pulse generator is adapted to generate a pacing signal to provide myocardium pacing. The controller is adapted to control the neural stimulator and the pulse generator to provide a cardioprotective conditioning therapy. The conditioning therapy includes neural stimulation to elicit a parasympathetic response and myocardium pacing. Other aspects and embodiments are provided herein.
摘要翻译： 各种系统实施例包括神经刺激器，脉冲发生器和控制器。 神经刺激器适于产生神经刺激信号。 脉冲发生器适于产生起搏信号以提供心肌起搏。 控制器适用于控制神经刺激器和脉冲发生器以提供心脏保护性调理疗法。 调理疗法包括神经刺激以引发副交感神经反应和心肌起搏。 本文提供了其它方面和实施例。
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