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    Iron catalyzed cross coupling reactions of aromatic compounds
    1.
    发明授权
    Iron catalyzed cross coupling reactions of aromatic compounds 失效
    铁催化的芳族化合物的交叉偶联反应

    公开(公告)号：US07026478B2

    公开(公告)日：2006-04-11

    申请号：US10143404

    申请日：2002-05-10

    申请人： Alois Fürstner ,  Andreas Leitner ,  María Méndez

    发明人： Alois Fürstner ,  Andreas Leitner ,  María Méndez

    IPC分类号： C07D237/00 ,  C07D237/02 ,  C07D487/00 ,  C07D251/00 ,  C07D239/02 ,  C07D215/00 ,  C07D215/04 ,  C07D215/12 ,  C07C69/76 ,  C07C303/00

    CPC分类号： C07D213/64 ,  C07C1/326 ,  C07D213/06 ,  C07D213/16 ,  C07D215/06 ,  C07D217/02 ,  C07D237/08 ,  C07D239/38 ,  C07D239/74 ,  C07D241/12 ,  C07D241/42 ,  C07D251/20 ,  C07D487/04

    摘要： A process for the production of compounds Ar—R1 by means of a cross-coupling reaction of an organometallic reagent R1-M with an aromatic or heteroaromatic substrate Ar—X catalyzed by one or several iron salts or iron complexes as catalysts or pre-catalysts, present homogeneously or heterogeneously in the reaction mixture. This new invention exhibits substantial advantages over established cross coupling methodology using palladium- or nickel complexes as the catalysts. Most notable aspects are the fact that (i) expensive and/or toxic nobel metal catalysts are replaced by cheap, stable, commercially available and toxicologically benign iron salts or iron complexes as the catalysts or pre-catalysts, (ii) commercially attractive aryl chlorides as well as various aryl sulfonates can be used as starting materials, (iii) the reaction can be performed under “ligand-free” conditons, and (iv) the reaction times are usually very short.

    摘要翻译： 通过有机金属试剂R 1 -M与芳族或杂芳族底物Ar-X的交叉偶联反应生产化合物Ar-R 1的方法 由一种或多种铁盐或铁络合物催化，作为催化剂或预催化剂，在反应混合物中均匀或不均匀地存在。 与使用钯或镍络合物作为催化剂的已建立的交联方法相比，该新发明显示出显着的优点。 最显着的方面是（i）昂贵的和/或有毒的诺贝尔金属催化剂被廉价的，稳定的，可商购的和毒理学上良好的铁盐或铁络合物替代为催化剂或预催化剂，（ii）商业上吸引人的芳基氯化物 以及各种芳基磺酸盐可以用作原料，（iii）反应可以在“无配体”条件下进行，（iv）反应时间通常很短。

    Process for producing nickel(0)-phosphorus ligand complexes
    9.
    发明授权
    Process for producing nickel(0)-phosphorus ligand complexes 有权
    制备镍（0） - 磷配体络合物的方法

    公开(公告)号：US07705171B2

    公开(公告)日：2010-04-27

    申请号：US12279795

    申请日：2007-02-13

    申请人： Gerd Haderlein ,  Tobias Aechtner ,  Andreas Leitner ,  Peter Pfab ,  Hermann Luyken ,  Jens Scheidel

    发明人： Gerd Haderlein ,  Tobias Aechtner ,  Andreas Leitner ,  Peter Pfab ,  Hermann Luyken ,  Jens Scheidel

    IPC分类号： C07F15/04

    CPC分类号： B01J31/1845 ,  B01J31/24 ,  B01J2231/32 ,  B01J2531/847

    摘要： A process for preparing nickel(0)-phosphorus ligand complexes comprising at least one nickel(0) central atom and at least one phosphorus ligand by reacting a nickel(II) compound with a reducing agent in the presence of the ligand to give a reaction mixture, wherein a) the molar reducing agent:nickel(II) compound ratio in the reaction is from 1:1 to 1000:1, calculated as the molar ratio of the redox equivalents, b) the molar phosphorus ligand:nickel(II) compound ratio in the reaction is not more than 30:1, calculated as the molar P atoms:Ni atoms ratio, c) the nickel(0) content in the resulting reaction mixture is not more than 1.3% by weight and d) the resulting reaction mixture is extracted by adding at least one dinitrile and at least one hydrocarbon to form at least two immiscible phases.

    摘要翻译： 一种通过在配体存在下使镍（II）化合物与还原剂反应而制备包含至少一个镍（O）中心原子和至少一个磷配体的镍（0） - 磷配体络合物的方法，得到反应 混合物，其中a）摩尔还原剂：反应中的镍（II）化合物比例为1:1至1000:1，以氧化还原当量的摩尔比计算，b）磷配体：镍（II） 反应中的化合物比例不超过30:1，以P原子摩尔数计算：Ni原子比，c）所得反应混合物中的镍（0）含量不超过1.3重量％，d）所得的 通过加入至少一种二腈和至少一种烃以形成至少两个不混溶的相来萃取反应混合物。

    METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE
    10.
    发明申请
    METHOD FOR PRODUCING ORGANIC PHOSPHOROUS COMPOUNDS CONTAINING HALOGENE 有权
    用于生产含有卤素的有机磷化合物的方法

    公开(公告)号：US20090281356A1

    公开(公告)日：2009-11-12

    申请号：US12373336

    申请日：2007-07-03

    申请人： Robert Baumann ,  Tobias Aechtner ,  Wolfgang Siegel ,  Hermann Luyken ,  Peter Pfab ,  Jens Scheidel ,  Andreas Leitner ,  Andreas Glass

    发明人： Robert Baumann ,  Tobias Aechtner ,  Wolfgang Siegel ,  Hermann Luyken ,  Peter Pfab ,  Jens Scheidel ,  Andreas Leitner ,  Andreas Glass

    IPC分类号： C07F9/48

    CPC分类号： C07F9/4891 ,  C07F9/4875

    摘要： Method of producing compounds of the general formula XPR2(OR1)  I a where X is chlorine, bromine or iodine and R1 is an organic radical, by reacting compounds of the general formula X2PR2  II, in which X has the meaning given above and R2 is an organic radical, with compounds of the general formula R1OH  III, in which R1 has the meaning given above, to give a mixture IV, in that a) the postreaction is carried out at a temperature of from 50 to 240° C. and a pressure of from 0.001 to 0.9 bar, b) from the mixture IV the compounds I a are separated off from the compounds PR2(OR1)2  I b and, if appropriate, the compounds II and c) compounds I b and, if appropriate, unreacted compounds II are returned to the synthesis stage.

    摘要翻译： 通过使通式X 2 PR 2 II的化合物（其中X具有上面给出的含义，R 2）是通过使通式XPR2（OR1）Ia的化合物的制备方法，其中X是氯，溴或碘，R 1是有机基团 具有通式R 1 OH III的化合物的化合物，其中R 1具有上述含义，得到混合物IV，其中a）反应在50-240℃的温度和 压力为0.001至0.9巴，b）从混合物IV中，化合物I a与化合物PR2（OR1）2 I b分离，如果合适，分离出化合物II和c）化合物I b，如果合适， 未反应的化合物II返回到合成阶段。