公开(公告)号：US08142826B2

公开(公告)日：2012-03-27

申请号：US12185649

申请日：2008-08-04

申请人： Kan He ,  Marc Roller ,  Antoine Bily ,  Naisheng Bai ,  Jacques Dikansky ,  Alvin Ibarra

发明人： Kan He ,  Marc Roller ,  Antoine Bily ,  Naisheng Bai ,  Jacques Dikansky ,  Alvin Ibarra

IPC分类号： A61K36/63

CPC分类号： A61K36/63 ,  A61K31/7088

摘要： A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl)methyl ester, commonly called excelside A, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4-hydroxyphenyl)ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.

摘要翻译： 可以通过阻断脂肪合成，激活PPAR-α，增加降血糖活性，降低体重，控制空腹血浆胰岛素水平与高胰岛素血症的关系，以及促进胰岛素敏感性以及促进胰岛素敏感性的方法，将Fraxinus excelsior种子提取物用于治疗受试者（包括人） 引起有益的急性促胰岛素作用。 Fraxinus excelsior种子提取物尤其包括分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2 - [（6-O- [b] -D-吡喃葡萄糖基 - D-吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）甲酯，通常称为excelside A，分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基 - 2 - [（6-O-和bgr-D-吡喃葡萄糖基-β-吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）2-（4-羟基苯基）乙酯，通常称为excelside B ，和化合物GI5，GI3，硝酸ide酯和油甙二甲酯。

公开(公告)号：US20100278944A1

公开(公告)日：2010-11-04

申请号：US12435343

申请日：2009-05-04

申请人： Andrew Scholey ,  Alvin Ibarra ,  Kan He ,  Marc Roller ,  Jacques Dikansky

发明人： Andrew Scholey ,  Alvin Ibarra ,  Kan He ,  Marc Roller ,  Jacques Dikansky

IPC分类号： A61K36/258 ,  A61P25/28

CPC分类号： A61K36/258

摘要： Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total genosides enhance cognitive function—including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.

摘要翻译： 公开的是通过施用美国人参来增强神经认知功能的方法。 优选的剂量范围为5至50mg的总苷类增强了认知功能，包括改善工作记忆（WM）性能，注意性能（例如，选择反应时间精度）和平静度。

公开(公告)号：US09011936B2

公开(公告)日：2015-04-21

申请号：US12580783

申请日：2009-10-16

申请人： Kan He ,  Marc Roller ,  Alvin Ibarra ,  Naisheng Bai ,  Jacques DiKansky

发明人： Kan He ,  Marc Roller ,  Alvin Ibarra ,  Naisheng Bai ,  Jacques DiKansky

IPC分类号： A61K36/53 ,  A61K36/00

CPC分类号： A61K36/53

摘要： Disclosed are methods of alleviating oxidative stress, regulating blood glucose levels, and controlling pancreatic lipase activity by administering a Rosemary extract. Such methods may be useful to help body weight and body fat, prevent obesity, and treat hyperglycemia, hyperinsulinemia, cardiovascular disease and Type-2 diabetes. Preferred extracts contain 20% or 50% carnosic acid.

摘要翻译： 公开了通过施用迷迭香提取物来减轻氧化应激，调节血糖水平和控制胰脂肪酶活性的方法。 这些方法可用于帮助体重和身体脂肪，预防肥胖，以及治疗高血糖症，高胰岛素血症，心血管疾病和2型糖尿病。 优选的提取物含有20％或50％的鼠尾草酸。

公开(公告)号：US20100112098A1

公开(公告)日：2010-05-06

申请号：US12263292

申请日：2008-10-31

申请人： Benoit Lemaire ,  Sophie Lafay ,  Karine Nardon ,  Alvin Ibarra ,  Marc Roller ,  Jacques Dikansky

发明人： Benoit Lemaire ,  Sophie Lafay ,  Karine Nardon ,  Alvin Ibarra ,  Marc Roller ,  Jacques Dikansky

IPC分类号： A61K36/82 ,  A61K31/235

CPC分类号： A61K31/235

摘要： A method of controlling body weight in humans by administering an amount of decaffeinated green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 5-caffeoylquinic acid (5-CQA) and total chlorogenic acids (tCGA) (5-CQA/tCGA) of between about 0.2 and 0.3. More preferably, the concentration of tCGA is greater than about 45% and the concentration of 5-CQA is less than about 10%. A preferred method of administration consists of administering between about 200 mg and about 1,000 mg per day, more preferably administering about 400 mg per day.

摘要翻译： 一种通过施用一定量的有效治疗受试者的脱咖啡因生咖啡提取物来控制人体重的方法。 一种优选的生咖啡提取物含有约5-30％的5-咖啡酰奎宁酸（5-CQA）和总绿原酸（tCGA）（5-CQA / tCGA）之比。 更优选地，tCGA的浓度大于约45％，并且5-CQA的浓度小于约10％。 优选的给药方法包括每天施用约200mg至约1,000mg，更优选每天施用约400mg。

公开(公告)号：US20100047372A1

公开(公告)日：2010-02-25

申请号：US12195303

申请日：2008-08-20

申请人： Benoit LEMAIRE ,  Sophie Lafay ,  Alvin Ibarra ,  Marc Roller ,  Jacques Dikansky

发明人： Benoit LEMAIRE ,  Sophie Lafay ,  Alvin Ibarra ,  Marc Roller ,  Jacques Dikansky

IPC分类号： A61K31/353 ,  A61K36/87 ,  A61P43/00

CPC分类号： A61K36/87

摘要： A method of enhancing physical performance during exercise by administering an amount of a grape extract effective to treat a subject. A preferred grape extract comprises a concentration of flavanol monomers of greater than about 5% by weight, and more preferably within a range from about 12% by weight to about 50% by weight, and a concentration of flavanol dimers preferably greater than about 2% by weight, and more preferably within a range from about 6% by weight to about 20% by weight. The flavanol monomers preferably include catechin, epicatechin, epicatechin gallate, and gallic acid. The flavanol dimers preferably include procyanidin B1, procyanidin B2, procyanidin B3, procyanidin B4, and procyanidin B2-O-gallate.

摘要翻译： 通过施用一定量的有效治疗受试者的葡萄提取物来增强运动期间的身体表现的方法。 优选的葡萄提取物包含大于约5重量％，更优选在约12重量％至约50重量％范围内的黄烷醇单体的浓度，并且黄烷醇二聚体的浓度优选大于约2重量％ ，更优选在约6重量％至约20重量％的范围内。 黄烷醇单体优选包括儿茶素，表儿茶素，表儿茶素没食子酸酯和没食子酸。 黄烷醇二聚体优选包括原花青素B1，原花青素B2，原花青素B3，原花青素B4和原花青素B2-O-没食子酸酯。

公开(公告)号：US09358264B2

公开(公告)日：2016-06-07

申请号：US13072648

申请日：2011-03-25

申请人： Alvin Ibarra ,  Marc Roller ,  Jacques DiKansky

发明人： Alvin Ibarra ,  Marc Roller ,  Jacques DiKansky

IPC分类号： A61K36/74 ,  A61K31/235 ,  A61K45/06

CPC分类号： A61K36/74 ,  A61K31/235 ,  A61K45/06

摘要： A method of controlling body weight in humans by administering an amount of decaffeinated green coffee extract effective to treat a subject. A preferred green coffee extract contains a ratio of 4-caffeoylquinic acid (4-CQA) to total chlorogenic acids (tCGA) (5-CQA/tCGA) of from about 0.1 to about 0.2. More preferably, the green coffee extract comprises from about 6% to about 8% of 4-caffeoylquinic acid and has a total chlorogenic acid concentration that exceeds about 45%. A preferred method of administration consists of administering the green coffee extracts is a dosage of about 200 mg twice a day prior to meals on an empty stomach.

摘要翻译： 一种通过施用一定量的有效治疗受试者的脱咖啡因生咖啡提取物来控制人体重的方法。 优选的生咖啡提取物含有约0.1-约0.2的4-咖啡酰奎宁酸（4-CQA）与总绿原酸（tCGA）（5-CQA / tCGA）的比例。 更优选地，生咖啡提取物包含约6％至约8％的4-咖啡酰奎尼酸，并且总绿原酸浓度超过约45％。 优选的给药方法包括在空腹时在饭前每天给予生咖啡提取物约200mg的剂量。

公开(公告)号：US08980342B2

公开(公告)日：2015-03-17

申请号：US12195303

申请日：2008-08-20

申请人： Benoit Lemaire ,  Sophie Lafay ,  Alvin Ibarra ,  Marc Roller ,  Jacques DiKansky

发明人： Benoit Lemaire ,  Sophie Lafay ,  Alvin Ibarra ,  Marc Roller ,  Jacques DiKansky

IPC分类号： A61K36/87 ,  A61K36/00

CPC分类号： A61K36/87

摘要： A method of enhancing physical performance during exercise by administering an amount of a grape extract effective to treat a subject. A preferred grape extract comprises a concentration of flavanol monomers of greater than about 5% by weight, and more preferably within a range from about 12% by weight to about 50% by weight, and a concentration of flavanol dimers preferably greater than about 2% by weight, and more preferably within a range from about 6% by weight to about 20% by weight. The flavanol monomers preferably include catechin, epicatechin, epicatechin gallate, and gallic acid. The flavanol dimers preferably include procyanidin B1, procyanidin B2, procyanidin B3, procyanidin B4, and procyanidin B2-O-gallate.

摘要翻译： 通过施用一定量的有效治疗受试者的葡萄提取物来增强运动期间的身体表现的方法。 优选的葡萄提取物包含大于约5重量％，更优选在约12重量％至约50重量％范围内的黄烷醇单体的浓度，并且黄烷醇二聚体的浓度优选大于约2重量％ ，更优选在约6重量％至约20重量％的范围内。 黄烷醇单体优选包括儿茶素，表儿茶素，表儿茶素没食子酸酯和没食子酸。 黄烷醇二聚体优选包括原花青素B1，原花青素B2，原花青素B3，原花青素B4和原花青素B2-O-没食子酸酯。

公开(公告)号：US20090117214A1

公开(公告)日：2009-05-07

申请号：US12185649

申请日：2008-08-04

申请人： Kan He ,  Marc Roller ,  Antonie Bily ,  Naisheng Bai ,  Jacques Dikansky ,  Alvin Ibarra

发明人： Kan He ,  Marc Roller ,  Antonie Bily ,  Naisheng Bai ,  Jacques Dikansky ,  Alvin Ibarra

IPC分类号： A61K36/63 ,  A61K31/7088 ,  A61P3/00 ,  C07G3/00

CPC分类号： A61K36/63 ,  A61K31/7088

摘要： A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) oxy]-3,4-dihydro-5-(methoxycarbonyl)methyl ester, commonly called excelside A, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4-hydroxyphenyl)ethyl ester, commonly called excelside B, and the compounds G15, G13, nuzhenide, and oleoside dimethyl ester.

摘要翻译： 可以通过阻断脂肪合成，激活PPAR-α，增加降血糖活性，降低体重，控制空腹血浆胰岛素水平与高胰岛素血症的关系，以及促进胰岛素敏感性以及促进胰岛素敏感性的方法，将可以用于治疗受试者（包括人）的Fraxinus excelsior种子提取物 引起有益的急性促胰岛素作用。 Fraxinus excelsior种子提取物尤其包括分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2 - [（6-O-β-D-吡喃葡萄糖基-β-D - 吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）甲酯，通常称为excelside A，分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2- 氧基] -3,4-二氢-5-（甲氧基羰基）-2-（4-羟基苯基）乙酯（通常称为excelside B）的化合物和化合物（6-O-β-D-吡喃葡萄糖基-β-D-吡喃葡萄糖基） G15，G13，nunzhenide和油脂二甲酯。

公开(公告)号：US08968800B2

公开(公告)日：2015-03-03

申请号：US13288745

申请日：2011-11-03

申请人： Andrew Scholey ,  Alvin Ibarra ,  Kan He ,  Marc Roller ,  Jacques Dikansky

发明人： Andrew Scholey ,  Alvin Ibarra ,  Kan He ,  Marc Roller ,  Jacques Dikansky

IPC分类号： A61K36/258

CPC分类号： A61K36/258

摘要： Disclosed are methods of enhancing neurocognitive function by administering of American Ginseng. Preferred dosages in the range of 5 to 50 mg total genosides enhance cognitive function—including, improvement of working memory (WM) performance, attentional performance (e.g., Choice Reaction Time accuracy), and calmness.

摘要翻译： 公开的是通过施用美国人参来增强神经认知功能的方法。 优选的剂量范围为5至50mg的总苷类增强了认知功能，包括改善工作记忆（WM）性能，注意性能（例如，选择反应时间精度）和平静度。

公开(公告)号：US08293292B2

公开(公告)日：2012-10-23

申请号：US13294058

申请日：2011-11-10

申请人： Kan He ,  Marc Roller ,  Antoine Bily ,  Naisheng Bai ,  Jacques DiKansky ,  Alvin Ibarra

发明人： Kan He ,  Marc Roller ,  Antoine Bily ,  Naisheng Bai ,  Jacques DiKansky ,  Alvin Ibarra

IPC分类号： A61K36/63

CPC分类号： A61K36/63 ,  A61K31/7088

摘要： A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a human, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S,3E,4S)2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl)methyl ester, commonly called excelside A, an isolated compound (2S,3E,4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl)2-(4-hydroxyphenyl)ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.

摘要翻译： 可以通过阻断脂肪合成，激活PPAR-α，增加降血糖活性，降低体重，控制空腹血浆胰岛素水平与高胰岛素血症的关系，以及促进胰岛素敏感性以及促进胰岛素敏感性的方法，将可以用于治疗受试者（包括人）的Fraxinus excelsior种子提取物 引起有益的急性促胰岛素作用。 Fraxinus excelsior种子提取物尤其包括分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基-2 - [（6-O- [b] -D-吡喃葡萄糖基 - D-吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）甲酯，通常称为excelside A，分离的化合物（2S，3E，4S）2H-吡喃-4-乙酸-3-亚乙基 - 2 - [（6-O-和bgr-D-吡喃葡萄糖基-β-吡喃葡萄糖基）氧基] -3,4-二氢-5-（甲氧基羰基）2-（4-羟基苯基）乙酯，通常称为excelside B ，和化合物GI5，GI3，硝酸ide酯和油甙二甲酯。