公开(公告)号：US12121537B2

公开(公告)日：2024-10-22

申请号：US17936361

申请日：2022-09-28

申请人： RHA INVESTMENT LIMITED

发明人： Shawn J. Green

IPC分类号： A61K36/00 ,  A23L33/00 ,  A23L33/105 ,  A23L33/15 ,  A23L33/16 ,  A61K9/00 ,  A61K9/20 ,  A61K31/375 ,  A61K31/51 ,  A61K31/519 ,  A61K31/714 ,  A61K33/00 ,  A61K33/06 ,  A61K36/185 ,  A61K36/21 ,  A61K36/74 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  A61K47/46

CPC分类号： A61K33/00 ,  A23L33/105 ,  A23L33/15 ,  A23L33/16 ,  A23L33/30 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/2054 ,  A61K9/2068 ,  A61K31/375 ,  A61K31/51 ,  A61K31/519 ,  A61K31/714 ,  A61K33/06 ,  A61K36/185 ,  A61K36/21 ,  A61K36/74 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  A61K47/46 ,  A23V2002/00 ,  A61K36/74 ,  A61K2300/00 ,  A61K36/185 ,  A61K2300/00

摘要： Compositions and methods for improving nitric oxide levels in a subject, comprising administering to a subject, a composition comprising dietary nitrate derived from potassium nitrate, beet root (whole plant, powder, plant extract), and/or nitrate-rich leafy green portions (whole plant, powder, plant extract) that improve functional nitric oxide levels in subjects as shown by increasing salivary bioconversion of nitrate to nitrite, a necessary a required step for nitric oxide mediated health benefits. The disclosed novel compositions improve cardiac health, lowers blood pressure, intraocular pressure, and LDL and restores nitric oxide mediated cardiovascular benefits, including but not limited, restoring endothelium function and improving flow mediated dilation.

公开(公告)号：US20240245744A1

公开(公告)日：2024-07-25

申请号：US18099943

申请日：2023-01-22

申请人： Artis Asahel Clark

发明人： Artis Asahel Clark

IPC分类号： A61K36/74 ,  A61K9/00 ,  A61K9/107 ,  A61K31/00

CPC分类号： A61K36/74 ,  A61K9/0043 ,  A61K9/107 ,  A61K31/658

摘要： The therapeutic product invention states to the use of quantified solutions containing natural compounds of cannabidiol, CBDa, cannabigerol, CBGa combined with Uncaria tomentosas' hydroalcoholic extracts emulsified in saline solution in homogenous mixture administered intranasally. A natural respiratory immune booster with mechanisms against respiratory viruses and foreign substances (e.g. SARS-Cov-2 spike protein, bacterial, allergen) including; inhibition, reduction, blockage of cellular entry, and encapsulation and expulsion with minute impact of variant lineage. By induction of the interferon pathway both directly and indirectly following activation of the host immune response to viral pathogen, suppressing cytokine activation in response to viral infection, as well as blocks viral replication after entry into cells. Attaching to viral protein, mechanically inhibiting the SARS-COV-2 enzyme 3CLpro and disrupts the interface of the receptor-binding domain of angiotensin-converting enzyme 2 (RBD-ACE-2) as well as the SARS-COV-2 spike glycoprotein.

公开(公告)号：US20240180990A1

公开(公告)日：2024-06-06

申请号：US18286012

申请日：2022-04-07

申请人： TOKUYAMA CORPORATION ,  SCHOOL CORPORATION, AZABU VETERINARY MEDICINE EDUCATIONAL INSTITUTION

发明人： Kie YAMADA ,  Yoji INUI ,  Kazuhiro KAWAI ,  Tomomi KURUMISAWA

IPC分类号： A61K36/74 ,  A61P1/14

CPC分类号： A61K36/74 ,  A61P1/14

摘要： Methane production from ruminant digestion is reduced by allowing a ruminant to be fed on feed containing unfermented coffee grounds.

公开(公告)号：US20240148815A1

公开(公告)日：2024-05-09

申请号：US18280508

申请日：2022-03-08

申请人： NGN HEALTHCARE-NEW GENERATION NUTRACEUTICALS S.R.L.

发明人： Ettore Novellino ,  Gian Carlo Tenore

IPC分类号： A61K36/74 ,  A61K9/19 ,  A61K9/48 ,  A61K31/365 ,  A61K31/405 ,  A61K31/49 ,  A61K31/7048 ,  A61K36/28 ,  A61K36/48 ,  A61K36/515 ,  A61P3/04

CPC分类号： A61K36/74 ,  A61K9/19 ,  A61K9/485 ,  A61K9/4866 ,  A61K31/365 ,  A61K31/405 ,  A61K31/49 ,  A61K31/7048 ,  A61K36/28 ,  A61K36/48 ,  A61K36/515 ,  A61P3/04

摘要： The present invention describes a gastro-resistant pharmaceutical/nutraceutical composition comprising chincona cortex freeze-dried (Cinchona succirubra), chicory leaves and roots freeze-dried (Cichorium intybus, and/or Cichorium endivia, and/or Cichorium pumilum, and/or Cichorium spinosum), and gentian root freeze-dried (Gentiana lutea), and optionally griffonia seed extract (Griffonia simplicifolia). The nutraceutical composition object of the present invention is useful for appetite control, mealtime energy intake reduction, and body weight loss.

公开(公告)号：US20240050510A1

公开(公告)日：2024-02-15

申请号：US18265933

申请日：2021-12-09

申请人： The Open University

发明人： Ravid DORON

IPC分类号： A61K36/74 ,  A61K31/343 ,  A61K31/138 ,  A61K31/55 ,  A61K31/496 ,  A61P25/24 ,  A61P25/22 ,  A61K36/734

CPC分类号： A61K36/74 ,  A61K31/343 ,  A61K31/138 ,  A61K31/55 ,  A61K31/496 ,  A61P25/24 ,  A61P25/22 ,  A61K36/734

摘要： The present invention concerns methods and compositions employing a combination of Uncaria rhynchophylla (UR) herb and an antidepressant or anxiolytic drug therapy for treating or preventing anxiety, stress, depression, and/or symptoms thereof, wherein the combined administration of UR and the drug elicit a fast on-set response in the subject.

公开(公告)号：US11896600B2

公开(公告)日：2024-02-13

申请号：US17026263

申请日：2020-09-20

申请人： Kodimule Shyam Prasad

发明人： Kodimule Shyam Prasad

IPC分类号： A61K31/559 ,  A61K31/4045 ,  A61K36/74 ,  A61P25/28 ,  A61K9/00 ,  A61K31/522 ,  A61K31/216

CPC分类号： A61K31/559 ,  A61K31/4045 ,  A61K36/74 ,  A61P25/28 ,  A61K9/0053 ,  A61K31/216 ,  A61K31/522

摘要： The invention provides a composition comprising one or more hydroxytryptamides and method of its use in the treatment of neurodegenerative disorders. The invention includes embodiments wherein the composition comprises caffeine and chlorogenic acids. The composition finds use in the treatment of Alzheimer's disease and Parkinson's disease, including providing neuroprotection against the advancement of the symptoms of these disorders.

公开(公告)号：US11771864B2

公开(公告)日：2023-10-03

申请号：US16872689

申请日：2020-05-12

申请人： Jorge Neval Moll Neto

发明人： Jorge Neval Moll Neto ,  Silvia Siag Oigman ,  Jeffrey J. Christian ,  Benjamin Scott Arnett

IPC分类号： A61M21/02 ,  A61K36/74 ,  A24F42/20 ,  A24F42/60 ,  A61M15/00 ,  A61K9/00 ,  A61M15/06 ,  A61M15/08 ,  A61M11/00 ,  A61M11/04 ,  A24F40/20 ,  A61M21/00

CPC分类号： A61M21/02 ,  A24F42/20 ,  A24F42/60 ,  A61K9/0073 ,  A61K36/74 ,  A61M15/0001 ,  A61M15/003 ,  A61M15/06 ,  A61M15/08 ,  A24F40/20 ,  A61K9/0043 ,  A61M11/005 ,  A61M11/007 ,  A61M11/042 ,  A61M15/001 ,  A61M15/009 ,  A61M2021/0016 ,  A61M2021/0077 ,  A61M2205/18 ,  A61M2205/3569 ,  A61M2205/75 ,  A61M2205/8206

摘要： Devices, systems and methods are provided for delivering coffee-derived volatiles to a user, particularly for the treatment of addiction. The coffee volatiles are selected and delivered by devices and systems which allow for concentrated delivery to the olfactory system of the user in a controlled manner. The olfactory system is the part of the sensory system used for smelling or olfaction. Olfaction of such coffee volatiles in this prescribed fashion stimulates the reward system of the brain such that a specific desired outcome is achieved. In some embodiments, the desired outcome is a reduction in addiction symptoms or curbing of a sensation of addiction withdrawal.

公开(公告)号：US20230210936A1

公开(公告)日：2023-07-06

申请号：US17996076

申请日：2020-08-05

申请人： NANTONG UNIVERSITY

发明人： Xiaosong GU ,  Chunkang TANG ,  Leilei GONG ,  Xiaomin WANG ,  Xin TANG

IPC分类号： A61K36/8988 ,  A61K36/74 ,  A61K36/515 ,  A61K36/481 ,  A61K36/64 ,  A61K36/36 ,  A61K36/815 ,  A61K36/232 ,  A61K36/284 ,  A61K36/725 ,  A61K36/52 ,  A61K36/286 ,  A61K35/583 ,  A61P25/16

CPC分类号： A61K36/8988 ,  A61K36/74 ,  A61K36/515 ,  A61K36/481 ,  A61K36/64 ,  A61K36/36 ,  A61K36/815 ,  A61K36/232 ,  A61K36/284 ,  A61K36/725 ,  A61K36/52 ,  A61K36/286 ,  A61K35/583 ,  A61P25/16 ,  A61K2236/331 ,  A61K2236/37 ,  A61K2236/51

摘要： A traditional Chinese medicine compound preparation for treating Parkinson's disease and its preparation method and application are disclosed. The traditional Chinese medicine compound preparation comprises traditional Chinese medicine formula components and the traditional Chinese medicine formula components comprise the following raw material or raw material extracts by mass: 6-15 parts of uncaria rhynchophylla, 3-9 parts of gastrodia elata, 6-12 parts of Gentiana macrophylla, 10-20 parts of raw astragalus membranaceus, 10-20 parts of prepared rehmannia roots, 10-20 parts of achyranthes roots, 10-20 parts of wolfberry fruits, 10-20 parts of angelica sinensis, 10-20 parts of fried atractylodes macrocephala, 6-15 parts of fried spina date seeds, 3-12 parts of walnut kernels, 3-9 parts of safflower, and 20-30 parts of zaocys dhumnade.

公开(公告)号：US20230181487A1

公开(公告)日：2023-06-15

申请号：US18107348

申请日：2023-02-08

申请人： HIGHER OPTIONS GLOBAL, INC.

发明人： Jason Crawford

IPC分类号： A61K31/05 ,  A61K45/06 ,  A61K36/68 ,  A61K36/185 ,  A61K36/82 ,  A61K36/74 ,  A61K36/736 ,  A61K36/45 ,  A61K36/31 ,  A61K36/9066 ,  A61K31/522 ,  A61K36/79 ,  A61K31/4045 ,  A61K31/198 ,  A61K36/21 ,  A61K31/197 ,  A61K36/53 ,  A61K36/81

CPC分类号： A61K31/05 ,  A61K45/06 ,  A61K36/68 ,  A61K36/185 ,  A61K36/82 ,  A61K36/74 ,  A61K36/736 ,  A61K36/45 ,  A61K36/31 ,  A61K36/9066 ,  A61K31/522 ,  A61K36/79 ,  A61K31/4045 ,  A61K31/198 ,  A61K36/21 ,  A61K31/197 ,  A61K36/53 ,  A61K36/81

摘要： A composition includes ashwagandha in a range of 5% to 20%; plant-based nitric oxide-inducing ingredients in a range of 0.5% to 10%; coffee fruit extract in a range of 0.5% to 10%; grape seed extract in a range of 1% to 10%; Cordyceps in a range of 5% to 20%; extended-release caffeine in a range of 0.5% to 10%; whole coffee fruit extract in a range of 1% to 10%; Schisandra extract in a range of 1% to 10%; L-theanine in a range of 1% to 10%; and beet juice in a range of 20% to 60%.

公开(公告)号：US10350258B2

公开(公告)日：2019-07-16

申请号：US15669443

申请日：2017-08-04

申请人： Cognitive Clarity Inc.

发明人： Judy Cam ,  Thomas Lake ,  Qubai Hu ,  Joel Cummings ,  Alan D Snow

IPC分类号： A61K36/82 ,  A61K36/74

CPC分类号： A61K36/82 ,  A61K36/74 ,  A61K2300/00

摘要： Methods of treating the formation, deposition, accumulation, or persistence of beta-amyloid containing plaques and tau protein containing tangles including the step of treating the plaques or tangles with an effective amount of a composition comprising an Uncaria tomentosa extract and an oolong tea extract. Compositions containing an Uncaria tomentosa extract in combination with an oolong tea extract.