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公开(公告)号：US20060019311A1
公开(公告)日：2006-01-26
申请号：US11148945
申请日：2005-06-09
申请人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
发明人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S435/961 , Y10S436/823 , Y10S530/807
摘要： A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.
摘要翻译： 检测负责亚急性，可传染，海绵状脑病的朊病毒病原体的形式的方法，其包括游离或结合载体的大环佐剂配体（AML），其被添加到能够含有PrP sc 所得悬浮液然后与抗PrP超抗原反应，然后检测PrP的存在。
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公开(公告)号：US20070154885A1
公开(公告)日：2007-07-05
申请号：US11701334
申请日：2007-02-01
申请人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
发明人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S435/961 , Y10S436/823 , Y10S530/807
摘要： A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.
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公开(公告)号：US07217530B2
公开(公告)日：2007-05-15
申请号：US11148945
申请日：2005-06-09
申请人： Aly Moussa , Anthony William Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Nicoleta Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
发明人： Aly Moussa , Anthony William Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Nicoleta Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
IPC分类号： G01N33/53 , G01N33/551 , G01N33/547 , C12Q1/37 , C07K1/04
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S435/961 , Y10S436/823 , Y10S530/807
摘要： A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.
摘要翻译： 检测负责亚急性，可传染，海绵状脑病的朊病毒病原体的形式的方法，其包括游离或结合载体的大环佐剂配体（AML），其被添加到能够含有PrP sc 所得悬浮液然后与抗PrP超抗原反应，然后检测PrP的存在。
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4.发明申请Process for detecting PRPsc using an antibiotic from the family of aminoglycosides 失效使用来自氨基糖苷类家族的抗生素检测PRPsc的方法公开(公告)号：US20060014215A1
公开(公告)日：2006-01-19
申请号：US11151066
申请日：2005-06-13
申请人： Aly Moussa , Anthony Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Herve Perron , Ambroise Martin
发明人： Aly Moussa , Anthony Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Herve Perron , Ambroise Martin
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10T436/104998
摘要： A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPsc from a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPsc is also disclosed.
摘要翻译： 用于检测或诊断PrP 的ScP浓度的浓缩过程，其中从动物或人类生物体产生或获自动物或人类生物体的组织或生物液体与 来自氨基糖苷类的抗生素，优选链霉素或其衍生物之一。 还公开了使用这种抗生素从组织或生物流体中消除PrP sc 以及用于诊断与PrP 的存在相关的病理学的试剂盒。
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5.发明授权Process for detecting PrPSC using an antibiotic from the family of aminoglycosides 失效使用来自氨基糖苷类家族的抗生素检测PrPSC的方法公开(公告)号：US07695918B2
公开(公告)日：2010-04-13
申请号：US11151066
申请日：2005-06-13
申请人： Aly Moussa , Anthony William Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Hervé Perron , Ambroise Martin
发明人： Aly Moussa , Anthony William Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Hervé Perron , Ambroise Martin
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10T436/104998
摘要： A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPsc from a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPsc is also disclosed.
摘要翻译： 通过沉淀PrPsc来检测或诊断PrPsc的浓缩过程，其中从动物或人类生物体产生或获自动物或人类生物体的组织或生物流体与来自氨基糖苷类，优选链霉素或其衍生物之一的抗生素结合在一起。 还公开了使用这种抗生素从组织或生物流体中消除PrPsc和用于诊断与PrPsc存在相关的病理学的试剂盒。
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公开(公告)号：US08871837B2
公开(公告)日：2014-10-28
申请号：US13823304
申请日：2011-09-09
IPC分类号： C08K9/06 , B01J20/26 , G01N33/543 , C08G77/18
CPC分类号： C08G77/18 , B01J20/268 , G01N33/54313 , G01N33/54353 , G01N2600/00
摘要： A method for preparation of a molecular recognition element comprising the steps of binding a template to a surface of a carrier material, providing a recognition material to the surface of the carrier material, initiating polymerization of the recognition material on the surface of the carrier material, stopping the polymerization of the recognition material on the surface of the carrier material, and releasing the template from the surface of the carrier material and the polymerized recognition material. The method is characterized as an aim size of individual imprints is predefined, and the polymerization of the recognition material on the surface of the carrier material is stopped when a size of individual imprints of the polymerized recognition material essentially equals the predefined aim size. This method is readily applicable for preparation of a molecular recognition element useful as a drug, catalyst, competitive affinity ligand inhibitor, competitor, agonist, antagonist or diagnostic agent.
摘要翻译： 一种制备分子识别元件的方法，包括以下步骤：将模板结合到载体材料的表面，向载体材料的表面提供识别材料，引发识别材料在载体材料表面上的聚合， 停止载体材料表面上的识别材料的聚合，并从载体材料和聚合识别材料的表面释放模板。 该方法的特征在于预定义个体印记的目标尺寸，并且当聚合识别材料的单独印记的尺寸基本上等于预定义的目标尺寸时，停止载体材料表面上识别材料的聚合。 该方法容易适用于制备可用作药物，催化剂，竞争性亲和配体抑制剂，竞争剂，激动剂，拮抗剂或诊断剂的分子识别元件。
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公开(公告)号：US20130184418A1
公开(公告)日：2013-07-18
申请号：US13823304
申请日：2011-09-09
IPC分类号： C08G77/18
CPC分类号： C08G77/18 , B01J20/268 , G01N33/54313 , G01N33/54353 , G01N2600/00
摘要： A method for preparation of a molecular recognition element comprising the steps of binding a template to a surface of a carrier material, providing a recognition material to the surface of the carrier material, initiating polymerization of the recognition material on the surface of the carrier material, stopping the polymerization of the recognition material on the surface of the carrier material, and releasing the template from the surface of the carrier material and the polymerized recognition material. The method is characterized as an aim size of individual imprints is predefined, and the polymerization of the recognition material on the surface of the carrier material is stopped when a size of individual imprints of the polymerized recognition material essentially equals the predefined aim size. This method is readily applicable for preparation of a molecular recognition element useful as a drug, catalyst, competitive affinity ligand inhibitor, competitor, agonist, antagonist or diagnostic agent.
摘要翻译： 一种制备分子识别元件的方法，包括以下步骤：将模板结合到载体材料的表面，向载体材料的表面提供识别材料，引发识别材料在载体材料表面上的聚合， 停止载体材料表面上的识别材料的聚合，并从载体材料和聚合识别材料的表面释放模板。 该方法的特征在于预定义个体印记的目标尺寸，并且当聚合识别材料的单独印记的尺寸基本上等于预定义的目标尺寸时，停止载体材料表面上识别材料的聚合。 该方法容易适用于制备可用作药物，催化剂，竞争性亲和配体抑制剂，竞争剂，激动剂，拮抗剂或诊断剂的分子识别元件。
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