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公开(公告)号：US20060019311A1
公开(公告)日：2006-01-26
申请号：US11148945
申请日：2005-06-09
申请人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
发明人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S435/961 , Y10S436/823 , Y10S530/807
摘要： A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.
摘要翻译： 检测负责亚急性，可传染，海绵状脑病的朊病毒病原体的形式的方法，其包括游离或结合载体的大环佐剂配体（AML），其被添加到能够含有PrP sc 所得悬浮液然后与抗PrP超抗原反应，然后检测PrP的存在。
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公开(公告)号：US20070154885A1
公开(公告)日：2007-07-05
申请号：US11701334
申请日：2007-02-01
申请人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
发明人： Aly Moussa , Anthony Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S435/961 , Y10S436/823 , Y10S530/807
摘要： A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.
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公开(公告)号：US07217530B2
公开(公告)日：2007-05-15
申请号：US11148945
申请日：2005-06-09
申请人： Aly Moussa , Anthony William Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Nicoleta Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
发明人： Aly Moussa , Anthony William Coleman , Patrick Shahgaldian , Eric Da Silva , Ambroise Martin , Adina Nicoleta Lazar , Edwige Leclere , Marilyne Dupin , Herve Perron
IPC分类号： G01N33/53 , G01N33/551 , G01N33/547 , C12Q1/37 , C07K1/04
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10S435/961 , Y10S436/823 , Y10S530/807
摘要： A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and the presence of PrP is then detected.
摘要翻译： 检测负责亚急性，可传染，海绵状脑病的朊病毒病原体的形式的方法，其包括游离或结合载体的大环佐剂配体（AML），其被添加到能够含有PrP sc 所得悬浮液然后与抗PrP超抗原反应，然后检测PrP的存在。
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4.发明申请Method For Detecting Prp Using at Least One Positive Charge and/or at Least One Glycosidic Bond and a Ligand Other Than a Protein Ligand 失效用于使用至少一种正电荷和/或至少一种糖苷键和除蛋白质配体以外的配体来检测Prp的方法公开(公告)号：US20080176256A1
公开(公告)日：2008-07-24
申请号：US10583891
申请日：2005-01-19
申请人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
发明人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
IPC分类号： G01N33/00
CPC分类号： G01N33/6896 , G01N2800/2828
摘要： The invention relates to a method for detecting PrP in a biological human or animal sample that may contain PrP. The inventive method is characterised in that it uses a molecule containing at least one positive charge and/or at least one osidic bond and a ligand other than a proteinic ligand selected from macrocyclic ligands and glycosaminoglycanes.
摘要翻译： 本发明涉及用于检测可能含有PrP的生物人或动物样品中的PrP的方法。 本发明的方法的特征在于，其使用含有至少一个正电荷和/或至少一个奥斯卡的分子和除了选自大环配体和糖胺聚糖的蛋白质配体之外的配体。
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5.发明申请Method for detecting PrP using at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand 审中-公开使用至少一种正电荷和/或至少一种糖苷键和除蛋白质配体以外的配体来检测PrP的方法公开(公告)号：US20090286269A1
公开(公告)日：2009-11-19
申请号：US12457535
申请日：2009-06-15
申请人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
发明人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
IPC分类号： C12Q1/48 , G01N33/68 , G01N33/566
CPC分类号： G01N33/6896 , G01N2800/2828
摘要： A method for detecting PrP in a biological human or animal sample that may contain said PrP. The method is characterized in that it uses a molecule containing at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand selected from macrocyclic ligands and glycosaminoglycans.
摘要翻译： 用于检测可能含有所述PrP的生物人或动物样品中PrP的方法。 该方法的特征在于其使用含有至少一个正电荷和/或至少一个糖苷键的分子和除了选自大环配体和糖胺聚糖的蛋白质配体之外的配体。
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6.发明授权Method for detecting PrP using at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand 失效使用至少一种正电荷和/或至少一种糖苷键和除蛋白质配体以外的配体来检测PrP的方法公开(公告)号：US07566530B2
公开(公告)日：2009-07-28
申请号：US10583891
申请日：2005-01-19
申请人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
发明人： Anna Benscik-Reynier , Anthony William Coleman , Eric Da Silva , Marilyne Dupin , Edwige Leclere , Ambroise Martin , Aly Moussa , Herve Perron , Frederic Ronzon
CPC分类号： G01N33/6896 , G01N2800/2828
摘要： The invention relates to a method for detecting PrP in a biological human or animal sample that may contain PrP. The inventive method is characterised in that it uses a molecule containing at least one positive charge and/or at least one osidic bond and a ligand other than a proteinic ligand selected from macrocyclic ligands and glycosaminoglycanes.
摘要翻译： 本发明涉及用于检测可能含有PrP的生物人或动物样品中的PrP的方法。 本发明的方法的特征在于，其使用含有至少一个正电荷和/或至少一个奥斯卡的分子和除了选自大环配体和糖胺聚糖的蛋白质配体之外的配体。
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7.发明申请Process for detecting PRPsc using an antibiotic from the family of aminoglycosides 失效使用来自氨基糖苷类家族的抗生素检测PRPsc的方法公开(公告)号：US20060014215A1
公开(公告)日：2006-01-19
申请号：US11151066
申请日：2005-06-13
申请人： Aly Moussa , Anthony Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Herve Perron , Ambroise Martin
发明人： Aly Moussa , Anthony Coleman , Anna Bencsik-Reynier , Patrick Shahgaldian , Herve Perron , Ambroise Martin
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2828 , Y10T436/104998
摘要： A process of concentration by precipitation of PrPsc for detecting or diagnosing PrPsc, wherein a tissue or biological fluid stemming from or obtained from an animal or human organism is brought together with an antibiotic from the family of aminoglycosides, preferably streptomycin or one of its derivatives. The use of such an antibiotic for eliminating PrPsc from a tissue or biological fluid and a kit for diagnosing pathologies associated with the presence of PrPsc is also disclosed.
摘要翻译： 用于检测或诊断PrP 的ScP浓度的浓缩过程，其中从动物或人类生物体产生或获自动物或人类生物体的组织或生物液体与 来自氨基糖苷类的抗生素，优选链霉素或其衍生物之一。 还公开了使用这种抗生素从组织或生物流体中消除PrP sc 以及用于诊断与PrP 的存在相关的病理学的试剂盒。
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8.发明授权
公开(公告)号：US5728540A
公开(公告)日：1998-03-17
申请号：US468670
申请日：1995-06-06
IPC分类号： G01N33/53 , A61K38/00 , C07K1/18 , C07K14/47 , C12Q1/02 , G01N33/50 , G01N33/566 , C12Q1/37 , C12N5/00 , C12Q1/04 , G01N33/567
CPC分类号： C07K14/4713 , G01N33/5091 , A61K38/00 , Y10S424/16 , Y10S435/964 , Y10S436/827 , Y10S436/828
摘要： Gliotoxic factor in the isolated or purified state, characterized in that it possesses toxic activity with respect to human or animal astrocytic cells, having the effect of a cytomorphological disorganization of their network of intermediate filaments and/or a degradation of the proteins of said intermediate filaments and/or cell death, in particular by apoptosis.
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公开(公告)号：US20110243962A1
公开(公告)日：2011-10-06
申请号：US12997486
申请日：2009-07-08
IPC分类号： A61K39/42 , C07K16/10 , C07H21/04 , A61P37/04 , A61P31/12 , A61P25/00 , A61P25/18 , A61P17/06 , A61P35/00 , A61P3/10 , C12N15/63 , C12P21/02 , G01N33/566 , C12N5/10
CPC分类号： C07K16/1036 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention deals with a ligand comprising each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 and SEQ ID No. 6 or sequence having either number of substituted aminoacids within said sequences as indicated in the following, from 0 to 3 in CDR1(SEQ ID No. 1), from 0 to 2 in CDR2(SEQ ID No. 2), from 0 to 2 in CDR3(SEQ ID No. 3), from 0 to 1 in CDR4(SEQ ID No. 4), from 0 to 4 in CDR5(SEQ ID No. 5), from 0 to 2 in CDR6(SEQ ID No. 6), or aminoacids substituted with other aminoacids having equivalent chemical functions and properties, within said sequences SEQ ID No. 1 to SEQ ID No. 6.
摘要翻译： 本发明涉及包含SEQ ID No.1，SEQ ID No.2，SEQ ID No.3，SEQ ID No.4，SEQ ID No.5所示的每个互补决定区（CDR）和 SEQ ID No.6或在所述序列中具有任意数目的取代氨基酸的序列，如下所示，CDR1（SEQ ID No.1）中为0至3，CDR2（SEQ ID No.2）为0至2， 在CDR3（SEQ ID No.3）中为0至2，CDR4（SEQ ID No.4）为0至1，CDR5（SEQ ID No.5）为0至4，CDR6（SEQ ID NO：0）为0至2 SEQ ID NO：6），或在所述序列SEQ ID No.1至SEQ ID No.6内具有等同化学功能和性质的其它氨基酸取代的氨基酸。
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10.发明授权Multiple sclerosis-associated retroviral (MSRV) nucleic acids corresponding to the Env region 失效对应于Env区域的多发性硬化相关逆转录病毒（MSRV）核酸公开(公告)号：US07771927B1
公开(公告)日：2010-08-10
申请号：US09319156
申请日：1998-07-07
申请人： Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Frederic Bedin , Mireille Sodoyer , Catherine Ott , Francois Mallet , Herve Perron , Bernard Mandrand
发明人： Glaucia Paranhos-Baccala , Florence Komurian-Pradel , Frederic Bedin , Mireille Sodoyer , Catherine Ott , Francois Mallet , Herve Perron , Bernard Mandrand
CPC分类号： C07K14/4713 , C07K14/005 , C12N2740/10022
摘要： The invention concerns a nucleic material, in isolated or purified state, and a nucleotide fragment comprising a nucleotide sequence selected from the group consisting in (i) the sequences SEQ ID NO: 112, SEQ ID NO:114, SEQ ID NO: 117, SEQ ID NO: 120, SEQ ID NO. 124, SEQ ID NO: 130, SEQ ID NO: 141 and SEQ ID NO: 142, (ii) the complementary sequences of sequences (i); and (iii) the sequences equivalent to sequences (ii) and (iii), in particular the sequence having for every series of 100 contiguous monomers, at least 50%, preferably 70% homology with sequences (i) and (ii) respectively. The invention also concerns their uses for detecting a retrovirus associated with multiple sclerosis and/or rheumatoid arthritis.
摘要翻译： 本发明涉及分离或纯化状态的核酸，以及包含选自（i）序列SEQ ID NO：112，SEQ ID NO：114，SEQ ID NO：117， SEQ ID NO：120，SEQ ID NO： 124，SEQ ID NO：130，SEQ ID NO：141和SEQ ID NO：142，（ii）序列（i）的互补序列; 和（iii）与序列（ii）和（iii）相当的序列，特别是具有每100个连续单体的序列的序列，分别与序列（i）和（ii）具有至少50％，优选70％的同源性。 本发明还涉及其用于检测与多发性硬化和/或类风湿性关节炎相关的逆转录病毒的用途。
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