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公开(公告)号：US10278940B2
公开(公告)日：2019-05-07
申请号：US15336208
申请日：2016-10-27
Applicant: AmDerma Pharmaceuticals, LLC
Inventor： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC: A61K31/216 , A61K31/255 , A61K31/185 , A61K31/192 , A61K31/222 , A61K45/06 , A61K31/225 , C07C59/68 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K31/235 , C07C57/44 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , A61K31/10 , A61K9/00 , A61K31/095
Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
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2.发明申请Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer 审中-公开使用2,5-二羟基苯化合物和衍生物治疗皮肤癌公开(公告)号：US20170065547A1
公开(公告)日：2017-03-09
申请号：US15336208
申请日：2016-10-27
Applicant: AmDerma Pharmaceuticals, LLC
Inventor： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC: A61K31/255 , A61K31/095 , A61K45/06 , A61K31/192 , A61K9/00
CPC classification number: A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
Abstract translation: 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂化物，异构体或前药在治疗和/或预防皮肤癌中的用途。
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公开(公告)号：US20160008303A1
公开(公告)日：2016-01-14
申请号：US14863896
申请日：2015-09-24
Applicant: AmDerma Pharmaceuticals, LLC
Inventor： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC: A61K31/185 , A61K31/225 , A61Q17/04 , A61K45/06 , A61K8/46
CPC classification number: A61K31/185 , A61K8/368 , A61K8/466 , A61K31/10 , A61K31/192 , A61K31/222 , A61K31/225 , A61K31/60 , A61K31/618 , A61K45/06 , A61Q17/04 , A61Q19/08
Abstract: The present invention relates to the use of a 2,5-dihydroxybenzine derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or prophylactic treatment of, inter alia, dermatitis.
Abstract translation: 本发明涉及由式（I）表示的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂合物，异构体或前药用于治疗和/或预防性治疗特别是皮炎的用途。
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4.发明申请公开(公告)号：US20190192474A1
公开(公告)日：2019-06-27
申请号：US16292906
申请日：2019-03-05
Applicant: AmDerma Pharmaceuticals, LLC
Inventor： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC: A61K31/255 , A61K31/095 , C07C69/017 , A61K31/235 , C07C309/42 , C07C65/19 , A61K45/06 , A61K31/222 , A61K31/216 , A61K31/192 , A61K31/185 , A61K31/10 , C07C65/03 , C07C57/44 , C07C309/75 , C07C309/24 , C07C309/68 , A61K31/225 , C07C59/68 , C07C69/84 , A61K9/00
CPC classification number: A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, skin cancer.
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公开(公告)号：US10278941B2
公开(公告)日：2019-05-07
申请号：US15455844
申请日：2017-03-10
Applicant: AmDerma Pharmaceuticals, LLC
Inventor： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC: A61K31/255 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K45/06 , A61K31/225 , C07C59/68 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K31/235 , C07C57/44 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , A61K31/10 , A61K9/00 , A61K31/095
Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea.
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Patent Agency Ranking
公开(公告)号：US20180028484A1
公开(公告)日：2018-02-01
申请号：US15455844
申请日：2017-03-10
Applicant: AmDerma Pharmaceuticals, LLC
Inventor： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC: A61K31/255 , A61K31/185 , A61K31/235 , C07C309/42 , C07C65/19 , A61K9/00 , C07C69/84 , C07C59/68 , A61K31/225 , C07C309/68 , C07C309/24 , C07C309/75 , C07C57/44 , C07C65/03 , A61K31/10 , A61K45/06 , A61K31/222 , A61K31/216 , A61K31/192 , A61K31/095 , C07C69/017
CPC classification number: A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea.
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7.发明授权Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of rosacea 有权使用2,5-二羟基苯化合物和衍生物治疗酒渣鼻公开(公告)号：US09592216B2
公开(公告)日：2017-03-14
申请号：US14603784
申请日：2015-01-23
Applicant: AmDerma Pharmaceuticals, LLC
Inventor： Pedro Cuevas Sànchez , Guillermo Gimenez Gallego , Inigo Saenz de Tejada Gorman , Javier Angulo Frutos , Serafin Valverde Lopez , Antonio Romero Garrido , Rosa Maria Lozano Puerto
IPC: A61K31/255 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K45/06 , A61K31/225 , C07C59/68 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K31/235 , C07C57/44 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , A61K31/10
CPC classification number: A61K31/255 , A61K9/0014 , A61K31/095 , A61K31/10 , A61K31/185 , A61K31/192 , A61K31/216 , A61K31/222 , A61K31/225 , A61K31/235 , A61K45/06 , C07C57/44 , C07C59/68 , C07C65/03 , C07C65/19 , C07C69/017 , C07C69/84 , C07C309/24 , C07C309/42 , C07C309/68 , C07C309/75 , A61K2300/00
Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea.
Abstract translation: 本发明涉及式（I）的2,5-二羟基苯衍生物或其药学上可接受的盐，溶剂合物，异构体或前药用于治疗和/或预防酒渣肠炎的用途。
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公开(公告)号：US20130296282A1
公开(公告)日：2013-11-07
申请号：US13937464
申请日：2013-07-09
Applicant: AmDerma Pharmaceuticals, LLC
Inventor： Pedro Cuevas Sànchez
IPC: C07C309/29 , A61K45/06 , A61K31/185
CPC classification number: A61K31/185 , A61K9/0014 , A61K31/095 , A61K31/56 , A61K31/59 , A61K31/60 , A61K45/06 , C07C309/29
Abstract: The invention describes compositions and methods of use for 2,5-dihydroxybenzene sulfonic acid compounds and pharmaceutically acceptable salts thereof. The invention provides methods for (a) treating skin cancer; (b) treating cancer of the organs; (c) treating leukemia; (d) improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy; (e) treating rosacea; and (f) treating psoriasis by administration of a composition comprising at least one 2,5-dihydroxybenzene sulfonic acid compound or a pharmaceutically acceptable salt thereof, and, optionally at least one therapeutic agent. Also disclosed are compositions comprising administration of at least one 2,5-dihydroxybenzene sulfonic acid compound, or a pharmaceutically acceptable salt thereof, and, at least one therapeutic agent. In the invention the 2,5-dihydroxybenzene sulfonic acid compounds or pharmaceutically acceptable salts thereof are 2,5-dihydroxybenzene sulfonic acid, calcium 2,5-dihydroxybenzenesulfonate, potassium 2,5-dihydroxybenzenesulfonate, magnesium 2,5-dihydroxybenzenesulfonate and diethylamine 2,5-dihydroxybenzenesulfonate.
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公开(公告)号：US10441530B2
公开(公告)日：2019-10-15
申请号：US15697244
申请日：2017-09-06
Applicant: AmDerma Pharmaceuticals, LLC
Inventor： David W. Osborne , Pramod P. Sarpotdar , Arturo J. Angel , Inigo Saenz de Tejada Gorman , Pedro Cuevas Sànchez
Abstract: The invention relates to pharmaceutical compositions and related methods for the topical administration of polar drugs. In a particular embodiment, the invention relates to a pharmaceutical composition comprising an active pharmaceutical agent that is a polar drug, such as potassium 2,5-dihydroxybenzenesulfonate, at least one occlusive agent, and at least one stabilizer.
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公开(公告)号：US20180078495A1
公开(公告)日：2018-03-22
申请号：US15697244
申请日：2017-09-06
Applicant: AmDerma Pharmaceuticals, LLC
Inventor： David W. Osborne , Pramod P. Sarpotdar , Arturo J. Angel , Inigo Saenz de Tejada Gorman , Pedro Cuevas Sànchez
CPC classification number: A61K9/0014 , A61K31/185 , A61K47/06 , A61K47/10 , A61K47/26 , A61K47/38
Abstract: The invention relates to pharmaceutical compositions and related methods for the topical administration of polar drugs. In a particular embodiment, the invention relates to a pharmaceutical composition comprising an active pharmaceutical agent that is a polar drug, such as potassium 2,5-dihydroxybenzenesulfonate, at least one occlusive agent, and at least one stabilizer.
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