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公开(公告)号：US10858389B2
公开(公告)日：2020-12-08
申请号：US15561009
申请日：2016-03-25
申请人： Amgen Inc.
发明人： Sheng Cui , Krishnakumar Ranganathan , Richard Crockett , Ying Chen , Aleksander Swietlow , Kevin Crossley , Yun Shi , Karel Decroos , Etienne Moniotte
摘要： The instant disclosure is directed to solution phase fragment coupling methods for preparing etelcalcetide and its pharmaceutically acceptable salts.
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公开(公告)号：US11377474B2
公开(公告)日：2022-07-05
申请号：US16532344
申请日：2019-08-05
申请人： AMGEN INC.
发明人： Jeroen Bezemer , Ying Chen , Richard Crockett , Kevin Crossley , Sheng Cui , Liang Huang , Sian Jones , Asher Lower , Krishnakumar Ranganathan
摘要： A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided.
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公开(公告)号：US10407464B2
公开(公告)日：2019-09-10
申请号：US15300209
申请日：2015-04-03
申请人： AMGEN INC.
发明人： Jeroen Bezemer , Ying Chen , Richard Crockett , Kevin Crossley , Sheng Cui , Liang Huang , Sian Jones , Asher Lower , Krishnakumar Ranganathan
摘要： A method for preparing AMG 416, or a pharmaceutically acceptable salt thereof, is provided. AMG 416 is a synthetic, eight amino-acid selective peptide agonist of the calcium sensing receptor. It is being developed as an intravenous treatment of secondary hyperparathyroidism (SHPT) in hemodialysis patients with chronic kidney disease-mineral and bone disorder (CKD-MBD).
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公开(公告)号：US20180079777A1
公开(公告)日：2018-03-22
申请号：US15561009
申请日：2016-03-25
申请人： Amgen Inc.
发明人： Sheng Cui , Krishnakumar Ranganathan , Richard Crockett , Ying Chen , Aleksander Swietlow , Kevin Crossley , Yun Shi , Karel Decroos , Etienne Moniotte
CPC分类号： C07K1/026 , C07K1/18 , C07K5/081 , C07K5/1019 , C07K7/06
摘要： The instant disclosure is directed to solution phase fragment coupling methods for preparing etelcalcetide and its pharmaceutically acceptable salts.
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