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公开(公告)号：US20140302036A1
公开(公告)日：2014-10-09
申请号：US14203123
申请日：2014-03-10
Applicant: Amgen Inc.
Inventor： Hailing HSU , Ming ZHANG , Gunasekaran KANNAN , Frederick W. JACOBSEN , Wayne TSUJI
IPC: C07K16/24 , C07K16/46 , A61K45/06 , C07K16/22 , A61K39/395
CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2827 , C07K16/2875 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/94 , C07K2318/10 , C07K2319/70
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
Abstract translation: 本文描述了对BAFF和B7RP1特异性的双特异性蛋白质，编码这种蛋白质的核酸，制备此类蛋白质的方法以及这些蛋白质的用途。
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公开(公告)号：US20230265145A1
公开(公告)日：2023-08-24
申请号：US18001913
申请日：2021-06-25
Applicant: AMGEN INC.
Inventor： Hailing HSU , Ian FOLTZ , Marissa MOCK , Victor Mitch LUNA , Ming ZHANG , Sharon Lynn WANNBERG , Gamze Ozlem CAMDERE TAPIA , Timothy Patrick RILEY
CPC classification number: C07K14/5428 , C07K16/2803 , A61K38/00 , C07K2319/00
Abstract: Abstract: The present disclosure relates, in general, to muteins of IL-10 that are stable as monomers, antigen binding proteins that bind to TREM-1, and antigen binding proteins comprising IL-10 muteins and antigen binding moieties, e.g., anti-TREM-1 antibodies, and compositions thereof. The disclosure also provides methods of treating inflammatory disease, such as inflammatory bowel disease or ulcerative colitis, using the compositions.
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公开(公告)号：US20230128444A1
公开(公告)日：2023-04-27
申请号：US17936062
申请日：2022-09-28
Applicant: AMGEN INC.
Inventor： Hailing HSU , Ming ZHANG , Gunasekaran KANNAN , Frederick W. JACOBSEN , Wayne H. TSUJI
Abstract: Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
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