公开(公告)号：US20150031870A1

公开(公告)日：2015-01-29

申请号：US14487932

申请日：2014-09-16

Applicant: Amgen Inc.

Inventor： SIMON MARK JACKSON ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Wenyan Shen ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US20150087819A1

公开(公告)日：2015-03-26

申请号：US14562546

申请日：2014-12-05

Applicant: AMGEN INC.

Inventor： SIMON MARK JACKSON ,  NIGEL PELHAM CLINTON WALKER ,  DEREK EVAN PIPER ,  BEI SHAN ,  WENYAN SHEN ,  JOYCE CHI YEE CHAN ,  CHADWICK TERENCE KING ,  RANDAL ROBERT KETCHEM ,  CHRISTOPHER MEHLIN ,  TERESA ARAZAS CARABEO ,  QIONG CAO

IPC: C07K16/40

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US20130079502A1

公开(公告)日：2013-03-28

申请号：US13682698

申请日：2012-11-20

Applicant: AMGEN, INC.

Inventor： SIMON MARK JACKSON ,  BEI SHAN ,  WENYAN SHEN ,  JOYCE CHI YEE CHAN ,  CHADWICK TERENCE KING

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.