公开(公告)号：US11986529B2

公开(公告)日：2024-05-21

申请号：US17879441

申请日：2022-08-02

申请人： Amryt Endo, Inc.

发明人： Roni Mamluk ,  Moshe Tzabari ,  Karen Marom ,  Paul Salama ,  Irina Weinstein

IPC分类号： A61K47/44 ,  A61K9/00 ,  A61K9/10 ,  A61K9/48 ,  A61K31/70 ,  A61K31/7036 ,  A61K31/713 ,  A61K31/721 ,  A61K38/08 ,  A61K38/09 ,  A61K38/095 ,  A61K38/12 ,  A61K38/14 ,  A61K38/21 ,  A61K38/22 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/29 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/32 ,  A61K9/16 ,  A61K51/08 ,  A61K51/10

CPC分类号： A61K47/44 ,  A61K9/0031 ,  A61K9/0053 ,  A61K9/10 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/4891 ,  A61K31/70 ,  A61K31/7036 ,  A61K31/713 ,  A61K31/721 ,  A61K38/08 ,  A61K38/09 ,  A61K38/095 ,  A61K38/12 ,  A61K38/14 ,  A61K38/212 ,  A61K38/22 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/29 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/32 ,  A61K9/1623 ,  A61K51/083 ,  A61K51/1021 ,  A61K51/1024 ,  A61K51/1045

摘要： The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.

公开(公告)号：US11969471B2

公开(公告)日：2024-04-30

申请号：US17879430

申请日：2022-08-02

申请人： Amryt Endo, Inc.

发明人： Roni Mamluk ,  Moshe Tzabari ,  Karen Marom ,  Paul Salama ,  Irina Weinstein

IPC分类号： A61K47/44 ,  A61K9/00 ,  A61K9/10 ,  A61K9/48 ,  A61K31/70 ,  A61K31/7036 ,  A61K31/713 ,  A61K31/721 ,  A61K38/08 ,  A61K38/09 ,  A61K38/095 ,  A61K38/12 ,  A61K38/14 ,  A61K38/21 ,  A61K38/22 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/29 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/32 ,  A61K9/16 ,  A61K51/08 ,  A61K51/10

CPC分类号： A61K47/44 ,  A61K9/0031 ,  A61K9/0053 ,  A61K9/10 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/4891 ,  A61K31/70 ,  A61K31/7036 ,  A61K31/713 ,  A61K31/721 ,  A61K38/08 ,  A61K38/09 ,  A61K38/095 ,  A61K38/12 ,  A61K38/14 ,  A61K38/212 ,  A61K38/22 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/29 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26 ,  A61K47/32 ,  A61K9/1623 ,  A61K51/083 ,  A61K51/1021 ,  A61K51/1024 ,  A61K51/1045

摘要： The pharmaceutical compositions described herein include a suspension which comprises an admixture in solid form of a therapeutically effective amount of a therapeutic agent and at least one salt of a medium chain fatty acid and a hydrophobic medium, e.g. castor oil or glyceryl tricaprylate or a mixture thereof. The pharmaceutical compositions described herein contain medium chain fatty acid salts and are substantially free of alcohols. The pharmaceutical compositions may be encapsulated in a capsule. Methods of treating or preventing diseases by administering such compositions to affected subjects are also disclosed.