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1.发明申请公开(公告)号：US20090099111A1
公开(公告)日：2009-04-16
申请号：US12170078
申请日：2008-07-09
IPC分类号： A61K31/7105 , A61K31/713 , C07H21/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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2.发明申请公开(公告)号：US20090105175A1
公开(公告)日：2009-04-23
申请号：US12170104
申请日：2008-07-09
IPC分类号： A61K31/7105 , A61K31/713 , A61K31/7125 , A61P27/02 , C07H21/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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3.发明申请公开(公告)号：US20090099113A1
公开(公告)日：2009-04-16
申请号：US12170132
申请日：2008-07-09
IPC分类号： A61K31/7088 , C07H21/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
摘要翻译： 本发明涉及降低眼睛眼内压（IOP）的方法和组合物。 本发明的组合物包含短干扰核酸分子（siNA），包括但不限于减少与眼内液的产生或引流相关基因表达的siRNA。 本发明的组合物可用于制备用于治疗眼睛症状的药物，所述眼部病症显示增加的眼压，例如青光眼，感染，炎症，葡萄膜炎和糖尿病性视网膜病变。 本发明的方法包括向有需要的患者施用有效量的本发明的一种或多种siNA。
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公开(公告)号：US20090264501A9
公开(公告)日：2009-10-22
申请号：US11574428
申请日：2005-08-30
申请人： Ana I. Jimenez , Angela Sesto , Jose P. Roman , Irene Gascon , Gonzalo Gonzalez De Buitrago , Maria C. Jimenez
发明人： Ana I. Jimenez , Angela Sesto , Jose P. Roman , Irene Gascon , Gonzalo Gonzalez De Buitrago , Maria C. Jimenez
IPC分类号： A61K31/7088 , A61K31/7052 , C07H21/00 , C12Q1/02 , C12Q1/68 , A61P25/00 , A61P11/00 , A61K31/713 , A61P25/28 , A61P9/00 , A61P29/00 , A61P17/00 , A61K48/00
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2310/53
摘要： Methods and compositions for the downregulation of P2X7 receptor expression or activity are disclosed. Preferred compositions comprise siNA. The methods and compositions are useful in the treatment of diseases characterised by increased 112X7 receptor activity, such as neuronal degeneration, Alzheimer's disease, inflammatory diseases, and some cancers.
摘要翻译： 公开了P2X7受体表达或活性下调的方法和组合物。 优选的组合物包含siNA。 方法和组合物可用于治疗特征在于增加的112X7受体活性的疾病，例如神经元变性，阿尔茨海默氏病，炎性疾病和一些癌症。
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5.发明申请公开(公告)号：US20090105176A1
公开(公告)日：2009-04-23
申请号：US12170148
申请日：2008-07-09
IPC分类号： A61K31/7105 , A61K31/713 , A61K31/7125 , A61P27/02 , C07H21/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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6.发明申请公开(公告)号：US20090099114A1
公开(公告)日：2009-04-16
申请号：US12170157
申请日：2008-07-09
IPC分类号： A61K31/7052 , C07H21/00 , A61P27/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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7.发明申请公开(公告)号：US20090099112A1
公开(公告)日：2009-04-16
申请号：US12170116
申请日：2008-07-09
IPC分类号： A61K31/7088 , C07H21/02
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： The present invention relates to methods and compositions that decrease intraocular pressure (IOP) of the eye. The compositions of the invention comprise short interfering nucleic acid molecules (siNA) including, but not limited to, siRNA that decrease expression of genes associated with production or drainage of intraocular fluid. The compositions of the invention can be used in the preparation of a medicament for the treatment of an eye conditions displaying increased IOP such as glaucoma, infection, inflammation, uveitis, and diabetic retinopathy. The methods of the invention comprise the administration to a patient in need thereof an effective amount of one or more siNAs of the invention.
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公开(公告)号：US20090005330A1
公开(公告)日：2009-01-01
申请号：US11574428
申请日：2005-08-30
申请人： Ana I. Jimenez , Angela Sesto , Jose P. Roman , Irene Gascon , Gonzalo Gonzalez De Buitrago , Maria C. Jimenez
发明人： Ana I. Jimenez , Angela Sesto , Jose P. Roman , Irene Gascon , Gonzalo Gonzalez De Buitrago , Maria C. Jimenez
IPC分类号： A61K31/7052 , C07H21/00 , C12Q1/02 , C12Q1/68 , A61P25/00 , A61P9/00 , A61P29/00 , A61P17/00
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2310/53
摘要： Methods and compositions for the downregulation of P2X7 receptor expression or activity are disclosed. Preferred compositions comprise siNA. The methods and compositions are useful in the treatment of diseases characterised by increased 112X7 receptor activity, such as neuronal degeneration, Alzheimer's disease, inflammatory diseases, and some cancers.
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公开(公告)号：US20080249048A1
公开(公告)日：2008-10-09
申请号：US11858579
申请日：2007-09-20
CPC分类号： A61K31/7115 , A61K31/00 , Y02A50/486
摘要： Methods and compositions for the treatment of intestinal disorders, such as IBD and Crohn's disease, are disclosed. Preferred compositions include siNA. Also disclosed is a method of specifically targeting siNA to treat intestinal disorders by intrarectal administration of siNA compounds.
摘要翻译： 公开了用于治疗肠疾病如IBD和克罗恩病的方法和组合物。 优选的组合物包括siNA。 还公开了专门靶向siNA以通过直肠内施用siNA化合物治疗肠道疾病的方法。
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10.发明申请Treatment of Eye Disorders Characterized by an Elevated Intraocular Pressure by siRNAs 有权通过siRNA升高的眼内压治疗眼部疾病公开(公告)号：US20070270365A1
公开(公告)日：2007-11-22
申请号：US11574169
申请日：2005-08-23
CPC分类号： C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14
摘要： Sequences and protocols for treatment of eye conditions by use of RNA interference are disclosed. Target genes are selected from those responsible for aqueous flow or aqueous outflow, while particularly preferred conditions to be treated include glaucoma and uveitis.
摘要翻译： 公开了通过使用RNA干扰治疗眼睛状况的序列和方案。 靶基因选自负责水流或水流出的那些，而待治疗的特别优选的病症包括青光眼和葡萄膜炎。
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