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1.发明授权Neutralization of CD95 activity blocks invasion of glioblastoma cells in vivo 有权CD95活性中和阻断胶质母细胞瘤细胞侵袭公开(公告)号：US09309320B2
公开(公告)日：2016-04-12
申请号：US12521625
申请日：2007-12-28
申请人： Ana Martin-Villalba , Susanne Kleber , Benedikt Wiestler , Peter G. Krammer , Christel Herold-Mende , Ignacio Sancho-Martinez
发明人： Ana Martin-Villalba , Susanne Kleber , Benedikt Wiestler , Peter G. Krammer , Christel Herold-Mende , Ignacio Sancho-Martinez
IPC分类号： A61K39/00 , A61K38/00 , C07K16/28 , C07K14/705 , G01N33/566 , G01N33/574
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2317/76 , C07K2319/00 , C07K2319/30 , G01N33/566 , G01N33/57407 , G01N33/6863 , G01N2333/70578 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： The present invention relates to methods for treating an individual with high grade glioblastoma multiforme by preventing or disrupting the binding of CD95 to its ligand, CD95L, in vivo, whereupon that neutralization of CD95 activity reduces undesirable glial cell migration and invasion into body tissue.
摘要翻译： 本发明涉及通过在体内预防或破坏CD95与其配体CD95L的结合来治疗具有高级胶质母细胞瘤多形性的个体的方法，因此中和CD95活性降低了不希望的胶质细胞迁移和侵入体内组织。
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2.发明申请Neutralization of CD95 Activity Blocks Invasion of glioblastoma Cells In Vivo 有权CD95活性块的中和进入体内胶质母细胞瘤细胞公开(公告)号：US20100322922A1
公开(公告)日：2010-12-23
申请号：US12521625
申请日：2007-12-28
申请人： Ana Martin-Villalba , Susanne Kleber , Benedikt Wiestler , Peter G. Krammer , Christel Herold-Mende , Ignacio Sancho-Martinez
发明人： Ana Martin-Villalba , Susanne Kleber , Benedikt Wiestler , Peter G. Krammer , Christel Herold-Mende , Ignacio Sancho-Martinez
IPC分类号： A61K39/395 , G01N33/574 , A61P35/00
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K14/70575 , C07K14/70578 , C07K16/2878 , C07K2317/76 , C07K2319/00 , C07K2319/30 , G01N33/566 , G01N33/57407 , G01N33/6863 , G01N2333/70578 , G01N2500/00 , G01N2500/04 , G01N2500/10 , G01N2510/00
摘要： The present invention relates to methods for treating an individual with high grade glioblastoma multiforme by preventing or disrupting the binding of CD95 to its ligand, CD95L, in vivo, whereupon that neutralization of CD95 activity reduces undesirable glial cell migration and invasion into body tissue.
摘要翻译： 本发明涉及通过在体内预防或破坏CD95与其配体CD95L的结合来治疗具有高级胶质母细胞瘤多形性的个体的方法，因此中和CD95活性降低了不希望的胶质细胞迁移和侵入体内组织。
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公开(公告)号：US20110189194A1
公开(公告)日：2011-08-04
申请号：US13054269
申请日：2009-07-14
IPC分类号： A61K39/395 , A61P29/00 , A61P25/00
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K14/70575
摘要： The present invention refers to the use of an inhibitor of the CD95/CD95L system for the prevention and/or treatment of an inflammatory disorder or for the prevention and/or treatment of an inflammatory process in a neuronal disorder, particularly in a CNS disorder.
摘要翻译： 本发明涉及CD95 / CD95L系统的抑制剂用于预防和/或治疗炎性病症或预防和/或治疗神经元病症，特别是CNS病症中的炎性过程的用途。
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4.发明申请Death Receptor CD95 Controls Neurogenesis of Adult Neural Stem Cells in Vivo and in Vitro 审中-公开死亡受体CD95控制体内和体外成人神经干细胞的神经发生公开(公告)号：US20110300113A1
公开(公告)日：2011-12-08
申请号：US12442017
申请日：2007-09-19
IPC分类号： A61K35/12 , C12N5/10 , A61K31/7088 , C07H21/04 , C07K14/52 , A61P25/28 , A61P25/16 , A61P25/00 , C12N15/85 , C07K16/28
CPC分类号： C07K14/70575 , A61K38/00
摘要： The present invention relates to the activation of the CD95L/CD95 system for inducing neuronal differentiation in vitro and in vivo and the use of CD95L compositions to effect differentiation.
摘要翻译： 本发明涉及在体外和体内诱导神经元分化的CD95L / CD95系统的活化以及使用CD95L组合物进行分化。
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5.发明授权Inhibition of the CD95 ligand/receptor system for the treatment of neurological disorders and injuries 有权抑制CD95配体/受体系统治疗神经系统疾病和损伤公开(公告)号：US07935339B2
公开(公告)日：2011-05-03
申请号：US10545231
申请日：2004-02-10
申请人： Ana Martin-Villalba , Peter Krammer , Deana Demjen
发明人： Ana Martin-Villalba , Peter Krammer , Deana Demjen
IPC分类号： A61K39/395
CPC分类号： C07K16/2875 , A61K39/39541 , A61K2039/505 , A61K2300/00
摘要： The present invention relates to the use of inhibitors of the CD95 ligand/receptor system for the manufacture of a medicament for the treatment of neurological disorders or injuries in a mammal, particularly for the treatment of spinal cord injury, more particularly for the treatment of paraplegia.
摘要翻译： 本发明涉及CD95配体/受体系统抑制剂在制备用于治疗哺乳动物神经系统疾病或损伤的药物中的用途，特别是用于治疗脊髓损伤，特别是用于治疗截瘫 。
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6.发明申请Inhibition of the cd95 ligand/receptor system for the treatment of neurological disorders and injuries 有权抑制cd95配体/受体系统治疗神经系统疾病和损伤公开(公告)号：US20060234968A1
公开(公告)日：2006-10-19
申请号：US10545231
申请日：2004-02-10
申请人： Ana Martin-Villalba , Peter Krammer , Deana Demjen
发明人： Ana Martin-Villalba , Peter Krammer , Deana Demjen
IPC分类号： A61K48/00 , A61K38/17 , A61K39/395
CPC分类号： C07K16/2875 , A61K39/39541 , A61K2039/505 , A61K2300/00
摘要： The present invention relates to the use of inhibitors of the CD95 ligand/receptor system for the manufacture of a medicament for the treatment of neurological disorders or injuries in a mammal, particularly for the treatment of spinal cord injury, more particularly for the treatment of paraplegia.
摘要翻译： 本发明涉及CD95配体/受体系统抑制剂在制备用于治疗哺乳动物神经系统疾病或损伤的药物中的用途，特别是用于治疗脊髓损伤，特别是用于治疗截瘫 。
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