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公开(公告)号:US20150119364A1
公开(公告)日:2015-04-30
申请号:US14537771
申请日:2014-11-10
发明人: Stephen J. BAKER , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael DiPierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zegar , Yong-Kang Zhang , Huchen Zhou
IPC分类号: C07F5/04
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US20170258819A1
公开(公告)日:2017-09-14
申请号:US15599203
申请日:2017-05-18
发明人: Stephen J. BAKER , Virginia Sanders , Tsutomu Akama , Carolyn Bellinger-Kawahara , Yvonne Freund , Kirk R. Maples , Jacob J. Plattner , Yong-Kang Zhang , Huchen Zhou , Vincent S. Hernandez
CPC分类号: A61K31/69 , C07F5/027 , Y02A50/411
摘要: Methods of treating anti-inflammatory conditions through the use of boron-containing small molecules are disclosed.
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公开(公告)号:US20170066788A1
公开(公告)日:2017-03-09
申请号:US15355813
申请日:2016-11-18
发明人: Stephen J. BAKER , Tsutomu Akama , Carolyn Bellinger-Kawahara , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk R. Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
CPC分类号: C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US20160228463A1
公开(公告)日:2016-08-11
申请号:US15134286
申请日:2016-04-20
发明人: Stephen J. BAKER , Tsutomu Akama , Vincent S. Hernandez , Karin M. Hold , Kirk Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang , Gregory T. Fieldson , James J. Leyden
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US20170066787A1
公开(公告)日:2017-03-09
申请号:US15355393
申请日:2016-11-18
发明人: Stephen J. BAKER , Tsutomu Akama , Vincent S. Hernandez , Karin M. Hold , Kirk R. Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang , Gregory T. Fieldson
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译: 本发明涉及可用于治疗真菌感染的化合物,更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物,并具有允许化合物与患者接触时达到感染真菌的皮肤,指甲,毛发,爪或蹄特定部位的性质。 特别地,本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号:US20160206638A1
公开(公告)日:2016-07-21
申请号:US15091394
申请日:2016-04-05
发明人: Stephen J. BAKER , Tsutomu Akama , Vincent S. Hernandez , Karin M. Hold , Kirk Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang , Gregory T. Fieldson , James J. Leyden
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US20160151399A1
公开(公告)日:2016-06-02
申请号:US15046322
申请日:2016-02-17
发明人: Stephen J. BAKER , Tsutomu Akama , Vincent S. Hernandez , Karin M. Hold , Kirk Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang , Gregory T. Fieldson , James J. Leyden
IPC分类号: A61K31/69
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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公开(公告)号:US20150065459A1
公开(公告)日:2015-03-05
申请号:US14537694
申请日:2014-11-10
发明人: Stephen J. BAKER , Tsutomu Akama , Carolyn BELLINGER-KAWAHARA , Vincent S. Hernandez , Karin M. Hold , James J. Leyden , Kirk R. Maples , Jacob J. Plattner , Virginia Sanders , Yong-Kang Zhang
IPC分类号: C07F5/02
CPC分类号: C07F5/025 , A61K9/0012 , A61K31/69 , C07F5/02 , C07F5/027
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
摘要翻译: 本发明涉及可用于治疗真菌感染的化合物,更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物,并具有允许化合物与患者接触时达到感染真菌的皮肤,指甲,毛发,爪或蹄特定部位的性质。 特别地,本发明化合物具有促进钉板穿透的物理化学性质。
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公开(公告)号:US20140221631A1
公开(公告)日:2014-08-07
申请号:US14201459
申请日:2014-03-07
发明人: Stephen J. BAKER , Tsutomu Akama , Michael Richard Kevin Alley , Stephen J. Benkovic , Michael Dipierro , Vincent S. Hernandez , Karin M. Hold , Isaac Kennedy , Igor Likhotvorik , Weimin Mao , Kirk Maples , Jacob J. Plattner , Fernando Rock , Virginia Sanders , Aaron M. Stemphoski , George Petros Yiannikouros , Siead Zagar , Yong-Kang Zhang , Huchen Zhou
CPC分类号: C07F5/025 , A61K9/0012 , A61K9/08 , A61K31/69 , A61K31/70 , A61K31/7076 , A61K47/10 , C07F5/04 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , Y02A50/473
摘要: This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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