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1.发明授权Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy 失效放射性标记的血管活性肠肽类似物用于诊断和放射治疗公开(公告)号：US06608174B1
公开(公告)日：2003-08-19
申请号：US09629632
申请日：2000-07-31
申请人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Sarjana Dutt , Rajan T. Sharma , Rinku Ahuja , Anil K. Mishra , Lazar T. Mathew
发明人： Anand C. Burman , Sudhanand Prasad , Rama Mukherjee , Sarjana Dutt , Rajan T. Sharma , Rinku Ahuja , Anil K. Mishra , Lazar T. Mathew
IPC分类号： A61K3816
CPC分类号： C07K14/57563 , A61K38/00 , A61K51/08
摘要： The present invention encompasses radiolabeled peptide analogs of vasoactive intestinal peptide (VIP) labeled with a radionuclide useful for imaging target sites within mammalian living systems. The invention particularly provides radiolabeled VIP derivatives that bind selectively to the VIP receptor on target cells. Specifically, the invention relates to the radiolabeling of VIP-receptor specific agents and their subsequent use for radiodiagnostic and radiotherapeutic purposes. The invention encompasses methods for radiolabeling these peptides with radio-nuclides and the use of these peptides as scintigraphic imaging agents. The radiolabeled VIP derivatives of the present invention exhibit pharmacological activity and therefore are useful as either imaging agent for visualization of VIP-receptor positive tumors and metastases, as a radiodiagnostic agent or as a radio-therapeutic agent for the treatment of such tumors in vivo by specifically targeting the cytotoxic radionuclide selectively to the tumor site in mammalian living systems.
摘要翻译： 本发明包括用放射性核素标记的血管活性肠肽（VIP）的放射性标记肽类似物，其用于成像哺乳动物生物系统内的靶位点。 本发明特别提供了放射性标记的VIP衍生物，其选择性地结合靶细胞上的VIP受体。 具体地，本发明涉及VIP-受体特异性试剂的放射性标记及其随后用于放射诊断和放射治疗目的。 本发明包括用放射性核素放射性标记这些肽的方法以及这些肽作为闪烁照相成像剂的用途。 本发明的放射性标记的VIP衍生物显示药理活性，因此可用作VIP-受体阳性肿瘤和转移的可视化显像剂，作为放射诊断剂或作为放射治疗剂，用于通过 特别是将细胞毒性放射性核素选择性地靶向哺乳动物生命系统中的肿瘤部位。
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2.发明授权Rotor member for dynamoelectric machines with longitudinal passages of decreasing area communicating with radial core vents 失效用于电动机的转子构件，其具有与径向排气孔连通的减小区域的纵向通道
公开(公告)号：US3997803A
公开(公告)日：1976-12-14
申请号：US493994
申请日：1974-08-01
申请人： Anil K. Mishra
发明人： Anil K. Mishra
摘要： A rotor member is provided for dynamoelectric machines having a laminated core with radial ventilating ducts extending through the core and passages for ventilating air extending longitudinally of the core and communicating with the radial ducts. The longitudinal air passages decrease in cross-sectional area from one end of the core to the other in a manner to produce substantially equal velocity of air flow through all of the radial ducts to insure uniformity of temperature from one end of the rotor to the other.
摘要翻译： 提供了一种用于电动机的转子构件，其具有层叠铁心，其具有延伸穿过铁芯的径向通风管道和用于使沿着芯部纵向延伸并与径向管道连通的通风的通道。 纵向空气通道以从芯的一端到另一端的横截面积减小，以便产生基本相等的空气流通过所有径向管道的速度，以确保温度从转子的一端到另一端的均匀性 。
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公开(公告)号：US5768480A
公开(公告)日：1998-06-16
申请号：US327336
申请日：1994-10-21
申请人： James Melton Crawford, Jr. , Daniel L. Dvorak , Diane Judith Litman , Anil K. Mishra , Peter Frederick Patel-Schneider
发明人： James Melton Crawford, Jr. , Daniel L. Dvorak , Diane Judith Litman , Anil K. Mishra , Peter Frederick Patel-Schneider
摘要： Techniques for integrating rules into imperative object-oriented languages such as C++. C++ is extended to permit definition of rules as members of classes. When a rule is defined as a member of a class, a preprocessor receives the declaration of the rule's class and of any other class involved in the rule and generates additional data members and member functions for the classes. The additional members of the classes permit a complete implementation of the rule. No additional rule interpreter or decision network is required. The rule definition defines collections of objects linked by interobject pointers to which the rule applies. A rule is evaluated only if there is a change in a value mentioned in the rule in an object belonging to a collection of objects for the rule. The rule's condition is a sequence of bindings and tests. The bindings define a path through a collections of objects to which the rule applies, and the path is followed during evaluation. The rules thus implement access-limited logic.
摘要翻译： 将规则集成到诸如C ++的强制性面向对象语言中的技术。 扩展C ++以允许将规则定义为类的成员。 当规则被定义为类的成员时，预处理程序将接收规则类和规则中涉及的任何其他类的声明，并为类生成附加的数据成员和成员函数。 这些课程的其他成员可以完全实施该规则。 不需要额外的规则解释器或决策网络。 规则定义定义了应用规则的对象指针链接的对象集合。 只有属性属于规则对象集合的对象中规则中提到的值发生更改时，才会评估规则。 规则的条件是绑定和测试的顺序。 绑定定义通过规则应用于的对象集合的路径，并且在评估期间遵循路径。 因此，规则实施了访问限制逻辑。
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公开(公告)号：US4182966A
公开(公告)日：1980-01-08
申请号：US827044
申请日：1977-08-23
摘要： A ventilation system is provided for dynamoelectric machines such as hydro generators having salient pole rotors and in which the rotor and stator have separate ventilation systems sealed from the air gap. The stator ventilation system includes radial vent ducts with longitudinal ducts in the stator core extending between adjacent radial vent ducts. The longitudinal ducts are sealed from the air gap and are disposed in the region of the stator windings, preferably extending through the teeth. Ventilating air flows radially inward through the vent ducts, longitudinally through the longitudinal ducts from one vent duct to the next, and radially outward to the external circuit where it is circulated through coolers, by means of a blower or otherwise.
摘要翻译： 为诸如具有凸极转子的水力发电机的电动机提供通风系统，其中转子和定子具有与气隙密封的单独的通风系统。 定子通风系统包括径向通风管道，定子芯中的纵向管道在相邻的径向通风管道之间延伸。 纵向管道与气隙密封并且设置在定子绕组的区域中，优选地延伸通过齿。 通风空气径向向内流过通风管道，纵向通过纵向管道从一个通风管道向下流动，并径向向外流动到外部回路，在那里通过鼓风机或其他方式循环通过冷却器。
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