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    Compositions and methods for treating malaria with cupredoxin and cytochrome
    8.
    发明授权
    Compositions and methods for treating malaria with cupredoxin and cytochrome 有权
    用氧还蛋白和细胞色素治疗疟疾的组合物和方法

    公开(公告)号：US07740857B2

    公开(公告)日：2010-06-22

    申请号：US12041411

    申请日：2008-03-03

    申请人： Ananda Chakrabarty ,  Tapas Das Gupta ,  Tohru Yamada ,  Anita Chaudhari ,  Arsenio Fialho ,  Chang Soo Hong

    发明人： Ananda Chakrabarty ,  Tapas Das Gupta ,  Tohru Yamada ,  Anita Chaudhari ,  Arsenio Fialho ,  Chang Soo Hong

    IPC分类号： A61K39/00 ,  A61K38/44 ,  C12P21/04 ,  C07K14/445

    CPC分类号： C07K14/195 ,  A61K38/00 ,  C07K14/35 ,  C07K14/80 ,  C12N9/0006

    摘要： The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by P. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.

    摘要翻译： 本发明涉及氧还蛋白和细胞色素及其分别或一起用于抑制哺乳动物红细胞和其他感染疟原虫的组织中寄生虫血症的扩散，特别是恶性疟原虫人红细胞的寄生虫血症 。 本发明提供了分离的肽，其是铜氧还蛋白或细胞色素c的变体，衍生物或结构等同物，以及可用于治疗或预防哺乳动物疟疾感染的铜氧还蛋白和/或细胞色素c或其变体，衍生物或其结构等同物的组合物。 此外，本发明提供了治疗哺乳动物患者预防或抑制哺乳动物疟疾感染生长的方法。 本发明还提供了防止昆虫载体中疟疾感染生长的方法。

    COMPOSITIONS AND METHODS FOR TREATING MALARIA WITH CUPREDOXIN AND CYTOCHROME
    9.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATING MALARIA WITH CUPREDOXIN AND CYTOCHROME 有权
    用丙泊酚和细胞色素处理疟疾的组合物和方法

    公开(公告)号：US20080293619A1

    公开(公告)日：2008-11-27

    申请号：US11861536

    申请日：2007-09-26

    申请人： Ananda Chakrabarty ,  Tapas Das Gupta ,  Tohru Yamada ,  Anita Chaudhari ,  Arsenio Fialho ,  Chang Soo Hong

    发明人： Ananda Chakrabarty ,  Tapas Das Gupta ,  Tohru Yamada ,  Anita Chaudhari ,  Arsenio Fialho ,  Chang Soo Hong

    IPC分类号： A61K38/00 ,  A61K31/70 ,  A61P31/00

    CPC分类号： C07K14/195 ,  A61K38/00 ,  C07K14/35 ,  C07K14/80 ,  C12N9/0006

    摘要： The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by P. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.

    摘要翻译： 本发明涉及氧还蛋白和细胞色素及其分别或一起用于抑制哺乳动物红细胞和其他感染疟原虫的组织中寄生虫血症的扩散，特别是恶性疟原虫人红细胞的寄生虫血症 。 本发明提供了分离的肽，其是铜氧还蛋白或细胞色素c的变体，衍生物或结构等同物，以及可用于治疗或预防哺乳动物疟疾感染的铜氧还蛋白和/或细胞色素c或其变体，衍生物或其结构等同物的组合物。 此外，本发明提供了治疗哺乳动物患者预防或抑制哺乳动物疟疾感染生长的方法。 本发明还提供了防止昆虫载体中疟疾感染生长的方法。

    Compositions and methods for treating malaria with cupredoxin and cytochrome
    10.
    发明授权
    Compositions and methods for treating malaria with cupredoxin and cytochrome 有权
    用氧还蛋白和细胞色素治疗疟疾的组合物和方法

    公开(公告)号：US07338766B2

    公开(公告)日：2008-03-04

    申请号：US11436590

    申请日：2006-05-19

    申请人： Ananda Chakrabarty ,  Tapas Das Gupta ,  Tohru Yamada ,  Anita Chaudhari ,  Arsenio Fialho ,  Chang Soo Hong

    发明人： Ananda Chakrabarty ,  Tapas Das Gupta ,  Tohru Yamada ,  Anita Chaudhari ,  Arsenio Fialho ,  Chang Soo Hong

    IPC分类号： C12Q1/68 ,  C12P21/04 ,  A61K38/00 ,  A61K38/44 ,  C07K14/445

    CPC分类号： C07K14/195 ,  A61K38/00 ,  C07K14/35 ,  C07K14/80 ,  C12N9/0006

    摘要： The present invention relates to cupredoxin and cytochrome and their use, separately or together, to inhibit the spread of parasitemia in mammalian red blood cells and other tissues infected by the malaria parasite, and in particular the parasitemia of human red blood cells by P. falciparum. The invention provides isolated peptides that are variants, derivatives or structural equivalents of cupredoxins or cytochrome c, and compositions comprising cupredoxins and/or cytochrome c, or variants, derivatives or structural equivalents thereof, that are useful for treating or preventing malaria infection in mammals. Further, the invention provides methods to treat mammalian patients to prevent or inhibit the growth of malarial infection in mammals. The invention also provides methods to prevent the growth of malaria infection in insect vectors.

    摘要翻译： 本发明涉及氧还蛋白和细胞色素及其分别或一起用于抑制哺乳动物红细胞和其他感染疟原虫的组织中寄生虫血症的扩散，特别是恶性疟原虫人红细胞的寄生虫血症 。 本发明提供了分离的肽，其是铜氧还蛋白或细胞色素c的变体，衍生物或结构等同物，以及可用于治疗或预防哺乳动物疟疾感染的铜氧还蛋白和/或细胞色素c或其变体，衍生物或其结构等同物的组合物。 此外，本发明提供了治疗哺乳动物患者预防或抑制哺乳动物疟疾感染生长的方法。 本发明还提供了防止昆虫载体中疟疾感染生长的方法。