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公开(公告)号:US08796443B2
公开(公告)日:2014-08-05
申请号:US13120342
申请日:2009-09-22
申请人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
发明人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
IPC分类号: C07H21/00 , C12N15/113 , C12N15/11
CPC分类号: C12N15/1136 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/3515 , C12N2310/3519 , C12N2310/3521 , C12N2320/32 , C12N2320/51 , C12N2320/53
摘要: The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing.
摘要翻译: 本发明涉及具有最小双链区的RNAi构建体及其在基因沉默中的应用。 与本发明相关的RNAi构建体包括8-14个核苷酸的双链区域和各种化学修饰,并且在基因沉默中是非常有效的。
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公开(公告)号:US09095504B2
公开(公告)日:2015-08-04
申请号:US13636748
申请日:2011-03-24
申请人: Lyn Libertine , Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
发明人: Lyn Libertine , Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
IPC分类号: C12N15/11 , A61K9/00 , A61K31/713 , A61K45/06
CPC分类号: C12N15/1136 , A61K9/0048 , A61K9/0051 , A61K31/713 , A61K45/06 , A61K47/554 , C12N2310/14 , C12N2310/313 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2320/31 , C12N2320/32 , A61K2300/00
摘要: The present invention relates to ocular administration of sd-rxRNA and rxRNAori molecules.
摘要翻译: 本发明涉及sd-rxRNA和rxRNAori分子的眼部给药。
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公开(公告)号:US09080171B2
公开(公告)日:2015-07-14
申请号:US13636728
申请日:2011-03-24
申请人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
发明人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
IPC分类号: C07H21/04 , C12N15/113 , C07H21/02 , C12N15/11
CPC分类号: C12N15/113 , C07H21/02 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/334 , C12N2310/335 , C12N2310/344 , C12N2310/351 , C12N2310/3515 , C12N2320/32 , C12N2320/51 , C12N2310/3521 , C12N2310/3533
摘要: The present invention relates to methods for in vivo administration of sd-rxRNA molecules.
摘要翻译: 本发明涉及体内施用sd-rxRNA分子的方法。
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公开(公告)号:US08664189B2
公开(公告)日:2014-03-04
申请号:US13120315
申请日:2009-09-22
申请人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , Pamela A. Pavco , James Cardia
发明人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , Pamela A. Pavco , James Cardia
IPC分类号: A61K48/00
CPC分类号: C12N15/1136 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/3515 , C12N2310/3519 , C12N2310/3521 , C12N2320/32 , C12N2320/51 , C12N2320/53
摘要: The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal applications.
摘要翻译: 本发明涉及具有改善的组织和细胞摄取特性的RNAi构建体以及在真皮应用中使用这些化合物的方法。
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公开(公告)号:US10041073B2
公开(公告)日:2018-08-07
申请号:US13069780
申请日:2011-03-23
申请人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
发明人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
IPC分类号: C12N15/113 , C12N15/11
CPC分类号: C12N15/1136 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/3515 , C12N2310/3519 , C12N2310/3521 , C12N2320/32 , C12N2320/51 , C12N2320/53
摘要: The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing. The RNAi constructs may be, for instance, miRNA constructs that are miRNA modulators.
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公开(公告)号:US20130131142A1
公开(公告)日:2013-05-23
申请号:US13636748
申请日:2011-03-24
申请人: Lyn Libertine , Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
发明人: Lyn Libertine , Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
IPC分类号: A61K9/00
CPC分类号: C12N15/1136 , A61K9/0048 , A61K9/0051 , A61K31/713 , A61K45/06 , A61K47/554 , C12N2310/14 , C12N2310/313 , C12N2310/321 , C12N2310/322 , C12N2310/3515 , C12N2320/31 , C12N2320/32 , A61K2300/00
摘要: The present invention relates to ocular administration of sd-rxRNA and rxRNAori molecules.
摘要翻译: 本发明涉及sd-rxRNA和rxRNAori分子的眼部给药。
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公开(公告)号:US20130131141A1
公开(公告)日:2013-05-23
申请号:US13636728
申请日:2011-03-24
申请人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
发明人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
IPC分类号: C12N15/113
CPC分类号: C12N15/113 , C07H21/02 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/334 , C12N2310/335 , C12N2310/344 , C12N2310/351 , C12N2310/3515 , C12N2320/32 , C12N2320/51 , C12N2310/3521 , C12N2310/3533
摘要: The present invention relates to methods for in vivo administration of sd-rxRNA molecules.
摘要翻译: 本发明涉及体内施用sd-rxRNA分子的方法。
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公开(公告)号:US09340786B2
公开(公告)日:2016-05-17
申请号:US13636755
申请日:2011-03-24
申请人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , Pamela A. Pavco , Lyn Libertine , James Cardia , Karen G. Bulock
发明人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , Pamela A. Pavco , Lyn Libertine , James Cardia , Karen G. Bulock
IPC分类号: A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113
CPC分类号: C12N15/1136 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/3341 , C12N2310/351 , C12N2310/3515 , C12N2320/32 , C12N2320/52 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要: The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal and fibrotic applications.
摘要翻译: 本发明涉及具有改善的组织和细胞摄取特性的RNAi构建体以及在真皮和纤维化应用中使用这些化合物的方法。
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公开(公告)号:US20140113950A1
公开(公告)日:2014-04-24
申请号:US13636755
申请日:2011-03-24
申请人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , Pamela A. Pavco , Lyn Libertine , James Cardia , Karen G. Bulock
发明人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , Pamela A. Pavco , Lyn Libertine , James Cardia , Karen G. Bulock
IPC分类号: C12N15/113
CPC分类号: C12N15/1136 , C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/3341 , C12N2310/351 , C12N2310/3515 , C12N2320/32 , C12N2320/52 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
摘要: The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal and fibrotic applications.
摘要翻译: 本发明涉及具有改善的组织和细胞摄取特性的RNAi构建体以及在真皮和纤维化应用中使用这些化合物的方法。
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公开(公告)号:US20120040459A1
公开(公告)日:2012-02-16
申请号:US13120342
申请日:2009-09-22
申请人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
发明人: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
IPC分类号: C12N5/071 , C12N15/113
CPC分类号: C12N15/1136 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/3515 , C12N2310/3519 , C12N2310/3521 , C12N2320/32 , C12N2320/51 , C12N2320/53
摘要: The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing.
摘要翻译: 本发明涉及具有最小双链区的RNAi构建体及其在基因沉默中的应用。 与本发明相关的RNAi构建体包括8-14个核苷酸的双链区域和各种化学修饰,并且在基因沉默中是非常有效的。
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