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公开(公告)号：US07228172B2
公开(公告)日：2007-06-05
申请号：US10734767
申请日：2003-12-13
申请人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
发明人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： An implantable bi-ventricular heart stimulating device and system, suitable for treating congestive heart failure, have a control circuit with first and second pacing circuits and first and second sensing circuits. The device operates with time cycles corresponding to normal heart cycles. The control circuit determines: (a) whether a signal typical of an evoked response to a pacing pulse delivered by the first pacing circuit is sensed within a first time interval and (b) whether a signal typical for an R-wave transferred from the second ventricle, or from some other part of the heart, to the first ventricle is detected within a first time window. The operation of the device depends on whether the conditions (a) and (b) are fulfilled.
摘要翻译： 适用于治疗充血性心力衰竭的可植入式双心室心脏刺激装置和系统具有具有第一和第二起搏电路和第一和第二感测电路的控制电路。 该装置以对应于正常心脏周期的时间周期运行。 控制电路确定：（a）在第一时间间隔内是否感测到由第一起搏电路传送的起搏脉冲的典型诱发响应的信号，以及（b）是否从第二时间间隔传送的R波的典型信号 在第一时间窗口内检测到心室或心脏的其他部分到第一脑室。 设备的操作取决于条件（a）和（b）是否得到满足。
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2.发明授权Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权可植入双心室刺激装置和系统，以及双心室刺激和感测方法公开(公告)号：US06961613B2
公开(公告)日：2005-11-01
申请号：US10712437
申请日：2003-11-13
CPC分类号： A61N1/3712 , A61N1/368 , A61N1/3684
摘要： An implantable bi-ventricular heart stimulating device has a control circuit that within a time cycle, delivers pacing pulses with both first and second pacing circuits with a time gap between a pacing pulse delivered by these pacing circuits. The time gap can be such that a pacing pulse delivered by the second pacing circuits falls substantially within a first time interval in which an evoked response can be expected to a pacing pulse delivered by the first pacing circuit. The control circuit performs a temporary modification of the operation of the device such that during at least one time cycle no pacing pulse is delivered by the second pacing circuit during the first time interval.
摘要翻译： 可植入的双心室心脏刺激装置具有控制电路，其在一个时间周期内，通过第一起搏电路和第二起搏电路之间的时间间隔在由这些起搏电路输送的起搏脉冲之间提供起搏脉冲。 时间间隙可以使得由第二起搏电路传送的起搏脉冲基本上落在第一时间间隔内，其中诱发响应可以预期到由第一起搏电路传送的起搏脉冲。 控制电路对装置的操作进行暂时的修改，使得在至少一个时间周期期间，第一起搏电路在第一时间间隔期间不发出起搏脉冲。
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3.发明授权Implantable bi-ventricular stimulation device and system, and bi-ventricular stimulation and sensing method 有权可植入双心室刺激装置和系统，以及双心室刺激和感测方法公开(公告)号：US07085602B2
公开(公告)日：2006-08-01
申请号：US10720449
申请日：2003-11-24
申请人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
发明人： Sven-Erik Hedberg , Asa Uhrenius , Karin Jarverud , Hans Strandberg , Nils Holmström , Anders Björling , Göran Budgifvars
IPC分类号： A61N1/365
CPC分类号： A61N1/368 , A61N1/056 , A61N1/3684 , A61N2001/0585
摘要： An implantable bi-ventricular heart stimulating device (10) has a control circuit with first and second sensing circuits for respectively sensing in the two ventricles and first and second stimulation circuits for respectively stimulating the two ventricles. The control circuit determines whether a signal, sensed by said second sensing circuit, occurs essentially simultaneously with a signal sensed by the first sensing circuit. Furthermore, the control circuit determines whether a further signal is sensed by said second sensing circuit within a predetermined time interval which follows after the signal sensed by the second sensing circuit but within the same time cycle as that signal. If this occurs, the control circuit determines whether the sensed signals represent actual cardiac events, or are likely the result of far field detection.
摘要翻译： 可植入式双心室心脏刺激装置（10）具有控制电路，该控制电路具有用于分别感测两个心室的第一和第二感测电路以及分别刺激两个脑室的第一和第二刺激电路。 控制电路确定由所述第二感测电路检测到的信号是否基本上与由第一感测电路感测的信号同时发生。 此外，控制电路确定在由第二感测电路感测到的信号之后但在与该信号相同的时间周期内的预定时间间隔内，所述第二感测电路是否感测到另外的信号。 如果发生这种情况，则控制电路确定感测到的信号是否代表实际的心脏事件，或者很可能是远场检测的结果。
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4.发明授权Cardiac stimulating and detecting device, system and method for identifying far field signals 有权用于识别远场信号的心脏刺激和检测装置，系统和方法公开(公告)号：US07184816B2
公开(公告)日：2007-02-27
申请号：US10864064
申请日：2004-06-09
IPC分类号： A61B5/04
CPC分类号： A61N1/37 , A61N1/3627 , A61N1/3684 , Y10S128/901
摘要： In an implantable heart stimulating device, system and method, a control circuit has first and second circuits for sensing and pacing. The first circuit can be connected to a first electrode member suited to be positioned in or at a first ventricle of the heart. The second circuit can be connected to a second electrode member suited to be positioned in or at a second ventricle of the heart. The control circuit is able to detect whether signals sensed by the second circuit are likely to be far field signals. The control circuit performs this detection by at least determining whether, during a predetermined time (length, more signals are sensed by the second circuit than by the first circuit.
摘要翻译： 在可植入心脏刺激装置，系统和方法中，控制电路具有用于感测和起搏的第一和第二电路。 第一电路可以连接到适于定位在心脏的第一心室中或第一心室处的第一电极构件。 第二电路可以连接到适于定位在心脏的第二心室中或第二心室处的第二电极构件。 控制电路能够检测由第二电路感测的信号是否可能是远场信号。 控制电路通过至少确定在预定时间（长度，由第二电路感测到的信号多于第一电路的信号）来执行该检测。
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公开(公告)号：US07089058B2
公开(公告)日：2006-08-08
申请号：US10813776
申请日：2004-03-31
IPC分类号： A61N1/368
CPC分类号： A61N1/3702 , A61N1/3684
摘要： A multi-chamber pacing system has a pulse generator for successively delivering pacing pulses to chambers of a patient's heart. Evoked response detectors having blanking intervals following the delivery of pacing pulses include sensing elements for sensing IEGM-signals from each of the heart chambers and an integrating unit that integrates the IEGM-signal within evoked response detection time windows after delivery of pacing pulses for detecting evoked response. The evoked response detection time window for a heart chamber contain at least one blanking interval resulting from delivery of a pacing pulse to another chamber and each of the sensed IEGM signals having a generally known morphology. An integral reconstructing unit reconstructs the time integral of the IEGM signal from one of the heart chambers in the blanking interval following delivery of a pacing pulse to another heart chamber.
摘要翻译： 多室起搏系统具有脉冲发生器，用于连续地向患者心脏的腔室输送起搏脉冲。 在递送起搏脉冲之后具有消隐间隔的诱发响应检测器包括用于感测来自每个心室的IEGM信号的感测元件和在递送用于检测诱发的起搏脉冲之后的诱发响应检测时间窗口内积分IEGM信号的积分单元 响应。 心室的诱发反应检测时间窗口包含至少一个消隐间隔，其由将起搏脉冲递送到另一个腔室而产生，每个感测的IEGM信号具有通常已知的形态。 整体重建单元在将起搏脉冲递送到另一个心室之后的消隐间隔中的一个心室重建IEGM信号的时间积分。
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公开(公告)号：US07069076B2
公开(公告)日：2006-06-27
申请号：US10761707
申请日：2004-01-21
IPC分类号： A61N1/36
CPC分类号： A61N1/3702 , A61N1/3684
摘要： A multi-chamber pacing system has a pulse generator for successively delivering pacing pulses to chambers of a patient's heart, and IEGM signal detectors, having blanking intervals following the delivery of pacing pulses, including sensing circuits for sensing IEGM-signals from each of the heart chambers. Each of said sensed IEGM signals has a generally known morphology. A signal-reconstructing unit reconstructs the IEGM signal from one of the heart chambers in the blanking interval following delivery of a pacing pulse to another heart chamber.
摘要翻译： 多室起搏系统具有脉冲发生器，用于连续地向患者心脏的腔室输送起搏脉冲，以及IEGM信号检测器，其具有递送起搏脉冲之后的消隐间隔，包括用于感测来自每个心脏的IEGM信号的感测电路 房间。 所述感测的IEGM信号中的每一个具有通常已知的形态。 信号重建单元在将起搏脉冲递送到另一个心室之后的消隐间隔中的一个心室重建IEGM信号。
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公开(公告)号：US06529777B1
公开(公告)日：2003-03-04
申请号：US09622817
申请日：2000-08-23
申请人： Nils Holmström , Sven-Erik Hedberg , Kenth Nilsson
发明人： Nils Holmström , Sven-Erik Hedberg , Kenth Nilsson
IPC分类号： A61N105
CPC分类号： A61N1/371 , A61N1/0565 , A61N1/362 , A61N1/36585
摘要： In an implantable electrode for an electrode lead for a stimulation device for stimulating tissue, the electrode is formed as a biocompatible piezoelectric electrode which is adapted to be in direct electrical contact with tissue for electrically and mechanically stimulating the tissue and for detecting electrical and mechanical evoked response of the stimulated tissue. The stimulation device can include circuitry for making a diagnosis of a heart condition using signals received from the implantable electrode.
摘要翻译： 在用于刺激组织的刺激装置的电极引线的可植入电极中，电极形成为生物相容性压电电极，其适于与组织直接电接触，用于电和机械刺激组织并检测电和机械诱发 刺激组织的反应。 刺激装置可以包括使用从可植入电极接收的信号进行心脏状况诊断的电路。
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公开(公告)号：US20100099994A1
公开(公告)日：2010-04-22
申请号：US12528160
申请日：2007-02-28
IPC分类号： A61B5/02
CPC分类号： A61B5/1107 , A61B5/0051 , A61B5/4519 , A61B5/6869 , A61N1/36578
摘要： An implantable heart analyzing device has a housing and a control circuit located within said housing. The control circuit generates an output signal adapted to actuate an activator, which is able to make a wall of the heart deflect or vibrate. The control circuit also communicates with a sensor, which can be identical with the activator, with which the movement of the heart wall can be sensed. The control circuit executes a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of the heart wall. An implantable heart analyzing includes the aforementioned heart analyzing device, as well as the activator and the sensor. The heart analyzing device and the system implement a method that results in generation of the aforementioned information concerning the tension of the heart wall.
摘要翻译： 可植入心脏分析装置具有壳体和位于所述壳体内的控制电路。 控制电路产生适于致动激活器的输出信号，其能够使心脏的壁发生偏转或振动。 控制电路还与传感器通信，传感器可以与激活器相同，通过该传感器可以感测心脏壁的移动。 控制电路执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够得出关于心壁的张力的信息。 可植入心脏分析包括上述心脏分析装置，以及活化剂和传感器。 心脏分析装置和系统实施导致产生上述关于心脏壁张力的信息的方法。
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公开(公告)号：US20100041970A1
公开(公告)日：2010-02-18
申请号：US12532186
申请日：2007-11-27
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
IPC分类号： A61B5/1459
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： An implantable medical device has an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison. The, indication signal is indicative of the lung functionality of the patient.
摘要翻译： 可植入医疗装置具有适于测量氧合血液中的氧气水平的氧传感器，并且根据氧气水平产生氧测量信号。 氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。 将获得的氧测量信号与预定阈值电平进行比较，并根据比较产生指示信号。 该指示信号表示患者的肺功能。
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公开(公告)号：US08620432B2
公开(公告)日：2013-12-31
申请号：US13171952
申请日：2011-06-29
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译： 可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。 基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。 针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。 选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。
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