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39 条记录 (耗时 0.03 秒)

    Pyridine, quinoline and pyrimidine derivatives
    1.
    发明授权
    Pyridine, quinoline and pyrimidine derivatives 失效
    吡啶，喹啉和嘧啶衍生物

    公开(公告)号：US07939661B2

    公开(公告)日：2011-05-10

    申请号：US11847467

    申请日：2007-08-30

    申请人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    发明人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    IPC分类号： C07D215/38 ,  A61K31/04

    CPC分类号： C07D401/12

    摘要： This invention is concerned with compounds of the formula wherein A, R1 to R5 are as defined in the specification and G is a pyridine, quinoline or pyrimidine group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

    摘要翻译： 本发明涉及下式的化合物，其中A，R 1至R 5如说明书中所定义，G为本说明书中所定义的吡啶，喹啉或嘧啶基团及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

    Substituted n-benzyl piperidines as somatostatin receptor modulators
    2.
    发明授权
    Substituted n-benzyl piperidines as somatostatin receptor modulators 失效
    取代的正丁基哌啶作为生长抑素受体调节剂

    公开(公告)号：US07799806B2

    公开(公告)日：2010-09-21

    申请号：US12053781

    申请日：2008-03-24

    申请人： Konrad Bleicher ,  Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    发明人： Konrad Bleicher ,  Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    IPC分类号： A61K31/445

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D471/04

    摘要： This invention relates to compounds of the formula wherein A, R1 to R3 are as defined in the claims and G is benzoimidazole, quinoxaline, benzotriazole, dihydro-imidazo[4,5-c]pyridinone and dihydro-isoindolone group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5 such as diabetes mellitus.

    摘要翻译： 本发明涉及下式的化合物，其中A，R 1至R 3如权利要求中所定义，G为本说明书中定义的苯并咪唑，喹喔啉，苯并三唑，二氢 - 咪唑并[4,5-c]吡啶酮和二氢 - 异吲哚酮基 及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5如糖尿病有关的疾病的用途。

    ARYLOXAZOLE, ARYLOXADIAZOLE AND BENZIMIDAZOLE DERIVATIVES
    3.
    发明申请
    ARYLOXAZOLE, ARYLOXADIAZOLE AND BENZIMIDAZOLE DERIVATIVES 审中-公开
    阿唑氧唑，阿魏酸和苯并咪唑衍生物

    公开(公告)号：US20080306116A1

    公开(公告)日：2008-12-11

    申请号：US12123508

    申请日：2008-05-20

    申请人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    发明人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    IPC分类号： A61K31/454 ,  C07D405/12

    CPC分类号： C07D413/12 ,  C07D401/12

    摘要： This invention relates to compounds of the formula wherein X is O or NR8, Y is CR7 or N, and R1 to R8 are as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

    摘要翻译： 本发明涉及下式的化合物，其中X为O或NR8，Y为CR7或N，R1至R8如说明书中所定义，及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

    4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES
    5.
    发明申请
    4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES 失效
    4,4-取代的哌啶衍生物

    公开(公告)号：US20080293756A1

    公开(公告)日：2008-11-27

    申请号：US12111230

    申请日：2008-04-29

    申请人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    发明人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    IPC分类号： A61K31/438 ,  C07D471/10

    CPC分类号： C07D471/10 ,  C07D211/66 ,  C07D401/12

    摘要： This invention relates to 4,4-disubstituted piperidine derivatives of the formula wherein A and R1 to R5 are as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

    摘要翻译： 本发明涉及下式的4,4-二取代哌啶衍生物，其中A和R 1至R 5如说明书中所定义，及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

    Substituted piperidine derivatives as SST5 modulators
    10.
    发明授权
    Substituted piperidine derivatives as SST5 modulators 失效
    取代哌啶衍生物作为SST5调节剂

    公开(公告)号：US07968568B2

    公开(公告)日：2011-06-28

    申请号：US12621542

    申请日：2009-11-19

    申请人： Andreas D. Christ ,  Rainer E. Martin

    发明人： Andreas D. Christ ,  Rainer E. Martin

    IPC分类号： A61K31/445

    CPC分类号： C07D473/16 ,  C07D401/12 ,  C07D487/04

    摘要： This invention is concerned with compounds of the formula wherein A, R1 to R5 and G are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

    摘要翻译： 本发明涉及下式的化合物，其中A，R 1至R 5和G如说明书和权利要求书中所定义，及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。