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120 条记录 (耗时 0.032 秒)

    ARYLOXAZOLE, ARYLOXADIAZOLE AND BENZIMIDAZOLE DERIVATIVES
    1.
    发明申请
    ARYLOXAZOLE, ARYLOXADIAZOLE AND BENZIMIDAZOLE DERIVATIVES 审中-公开
    阿唑氧唑，阿魏酸和苯并咪唑衍生物

    公开(公告)号：US20080306116A1

    公开(公告)日：2008-12-11

    申请号：US12123508

    申请日：2008-05-20

    申请人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    发明人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    IPC分类号： A61K31/454 ,  C07D405/12

    CPC分类号： C07D413/12 ,  C07D401/12

    摘要： This invention relates to compounds of the formula wherein X is O or NR8, Y is CR7 or N, and R1 to R8 are as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

    摘要翻译： 本发明涉及下式的化合物，其中X为O或NR8，Y为CR7或N，R1至R8如说明书中所定义，及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

    Pyridine, quinoline and pyrimidine derivatives
    3.
    发明授权
    Pyridine, quinoline and pyrimidine derivatives 失效
    吡啶，喹啉和嘧啶衍生物

    公开(公告)号：US07939661B2

    公开(公告)日：2011-05-10

    申请号：US11847467

    申请日：2007-08-30

    申请人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    发明人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    IPC分类号： C07D215/38 ,  A61K31/04

    CPC分类号： C07D401/12

    摘要： This invention is concerned with compounds of the formula wherein A, R1 to R5 are as defined in the specification and G is a pyridine, quinoline or pyrimidine group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

    摘要翻译： 本发明涉及下式的化合物，其中A，R 1至R 5如说明书中所定义，G为本说明书中所定义的吡啶，喹啉或嘧啶基团及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

    Substituted n-benzyl piperidines as somatostatin receptor modulators
    4.
    发明授权
    Substituted n-benzyl piperidines as somatostatin receptor modulators 失效
    取代的正丁基哌啶作为生长抑素受体调节剂

    公开(公告)号：US07799806B2

    公开(公告)日：2010-09-21

    申请号：US12053781

    申请日：2008-03-24

    申请人： Konrad Bleicher ,  Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    发明人： Konrad Bleicher ,  Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    IPC分类号： A61K31/445

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D471/04

    摘要： This invention relates to compounds of the formula wherein A, R1 to R3 are as defined in the claims and G is benzoimidazole, quinoxaline, benzotriazole, dihydro-imidazo[4,5-c]pyridinone and dihydro-isoindolone group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5 such as diabetes mellitus.

    摘要翻译： 本发明涉及下式的化合物，其中A，R 1至R 3如权利要求中所定义，G为本说明书中定义的苯并咪唑，喹喔啉，苯并三唑，二氢 - 咪唑并[4,5-c]吡啶酮和二氢 - 异吲哚酮基 及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5如糖尿病有关的疾病的用途。

    4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES
    5.
    发明申请
    4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES 失效
    4,4-取代的哌啶衍生物

    公开(公告)号：US20080293756A1

    公开(公告)日：2008-11-27

    申请号：US12111230

    申请日：2008-04-29

    申请人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    发明人： Andreas D. Christ ,  Rainer E. Martin ,  Peter Mohr

    IPC分类号： A61K31/438 ,  C07D471/10

    CPC分类号： C07D471/10 ,  C07D211/66 ,  C07D401/12

    摘要： This invention relates to 4,4-disubstituted piperidine derivatives of the formula wherein A and R1 to R5 are as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

    摘要翻译： 本发明涉及下式的4,4-二取代哌啶衍生物，其中A和R 1至R 5如说明书中所定义，及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

    PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES
    9.
    发明申请
    PYRIDINE, QUINOLINE AND PYRIMIDINE DERIVATIVES 失效
    吡啶，喹啉和吡嗪衍生物

    公开(公告)号：US20080064697A1

    公开(公告)日：2008-03-13

    申请号：US11847467

    申请日：2007-08-30

    申请人： Andreas Christ ,  Rainer Martin ,  Peter Mohr

    发明人： Andreas Christ ,  Rainer Martin ,  Peter Mohr

    IPC分类号： A61K31/496 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/5377 ,  A61P3/10 ,  C07D401/12 ,  C07D413/14

    CPC分类号： C07D401/12

    摘要： This invention is concerned with compounds of the formula wherein A, R1 to R5 are as defined in the specification and G is a pyridine, quinoline or pyrimidine group as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

    摘要翻译： 本发明涉及下式的化合物，其中A，R 1至R 5如说明书中所定义，G为吡啶，喹啉或嘧啶基团，如 说明书及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。

    ROTARY FEED-THROUGH WITH LEAKAGE SENSOR
    10.
    发明申请
    ROTARY FEED-THROUGH WITH LEAKAGE SENSOR 有权
    旋转进给 - 带泄漏传感器

    公开(公告)号：US20070034265A1

    公开(公告)日：2007-02-15

    申请号：US11460269

    申请日：2006-07-27

    申请人： Peter Mohr ,  Wolfgang Bechteler ,  Stephan Gast ,  Hans Leidl

    发明人： Peter Mohr ,  Wolfgang Bechteler ,  Stephan Gast ,  Hans Leidl

    IPC分类号： F16L27/08

    CPC分类号： F16L27/0828 ,  G01M3/183 ,  G01M3/2853 ,  Y10T137/8326 ,  Y10T137/86268

    摘要： The invention pertains to a rotary feed-through for supplying a fluid to a rotating machine part with a hollow shaft (3) that is rotatably supported in a housing (1, 2) and has a first sliding surface (29), with a sealing bushing (31) that is arranged in a rotationally fixed fashion within the housing (1, 2) coaxial to the shaft (3) and has a second sliding surface (30) for contacting the first sliding surface (29), and with a collecting chamber (27) that is arranged within the housing (1, 2) and serves for collecting the leakage fluid escaping between the two sliding surfaces (29, 30). The leakage fluid collected within the rotary feed-through can be monitored with the aid of a detection channel (26, 33, 34, 37, 39, 47) in the housing (1, 2) that is connected to the collecting chamber (27) and contains a leakage sensor (41).

    摘要翻译： 本发明涉及一种用于向旋转机器部件供应流体的旋转馈通，所述旋转机器部分具有可旋转地支撑在壳体（1,2）中并具有第一滑动表面（29）的中空轴（3） 衬套（31），其以与所述轴（3）同轴的所述壳体（1,2）内以旋转固定的方式布置，并且具有用于接触所述第一滑动表面（29）的第二滑动表面（30） 室（27），其布置在壳体（1,2）内，并用于收集在两个滑动表面（29,30）之间逸出的泄漏流体。 可以借助于连接到收集室（27）的壳体（1,2）中的检测通道（26,33,34,37,39,47）来监测在旋转通过内收集的泄漏流体， ）并且包含泄漏传感器（41）。