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    Isotopically labeled chemically stable reagents and process for the synthesis thereof
    7.
    发明授权
    Isotopically labeled chemically stable reagents and process for the synthesis thereof 有权
    同位素标记化学稳定的试剂及其合成方法

    公开(公告)号：US08987501B2

    公开(公告)日：2015-03-24

    申请号：US13644925

    申请日：2012-10-04

    申请人： PerkinElmer Health Sciences, Inc.

    发明人： Jerry Scot Pounds

    IPC分类号： C07C69/78 ,  C07C69/52 ,  C07C303/26 ,  C07B59/00 ,  C07C67/10 ,  C07C309/73 ,  C07D207/09 ,  C07D211/66 ,  C07D453/02

    CPC分类号： C07C303/26 ,  C07B59/00 ,  C07B59/001 ,  C07B59/002 ,  C07B2200/05 ,  C07C67/10 ,  C07C309/73 ,  C07D207/09 ,  C07D211/66 ,  C07D453/02 ,  C07C69/616

    摘要： A radioisotope labeled reagent includes a compound having the general formula (I), L-(aCbH2)naCbH3  (I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number between 1 and 3 inclusive, such that a in each occurrence is not 12 simultaneously with b in each occurrence being 1; L is a leaving group R1SO2—O—, R1—S—, 12C1H3(12C3H2)n—S—R1C(O)O—, NC—, (R1)3P—, XMg- and Li—, where n is an integer between 0 and 3 inclusive, where X is chloro, bromo or iodine, where R1 is H, aryl, a substituent containing aryl, C1-C20 alkyl, a substituent containing C1-C20 alkyl, C2-C20 alkenyl, a substitute containing C2-C20 alkenyl, C2-C20 alkynyl, and a substitute containing C2-C20 alkynyl with the proviso that when n is 0, a is 13 and b is 2 and R1 in R1—S is not aryl.

    摘要翻译： 放射性同位素标记试剂包括具有通式（I）的化合物，L-（aCbH 2）naCbH 3（I），其中每次独立地为11〜14的碳质量数，b各自独立地为氢原子 数字在1和3之间，其中a在每次出现时不是12，而b在每次出现时都是1; L是离去基团R1SO2-O-，R1-S-，12C1H3（12C1H2）n-S-R1C（O）O-，NC-，（R1）3P-，XMg-和Li-，其中n是整数 在0和3之间，其中X是氯，溴或碘，其中R 1是H，芳基，含有芳基的取代基，C 1 -C 20烷基，含有C 1 -C 20烷基的取代基，C 2 -C 20烯基， C20烯基，C2-C20炔基和含C2-C20炔基的取代基，条件是当n为0时，a为13，b为2，R1-S中的R1不为芳基。