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    Process for Preparing Nitriles by Elimination Reactions
    1.
    发明申请
    Process for Preparing Nitriles by Elimination Reactions 有权
    通过消除反应制备腈的方法

    公开(公告)号：US20080242884A1

    公开(公告)日：2008-10-02

    申请号：US11996105

    申请日：2006-07-05

    申请人： Andreas Meudt ,  Sven Nerdinger ,  Claudius Boehm

    发明人： Andreas Meudt ,  Sven Nerdinger ,  Claudius Boehm

    IPC分类号： C07C253/20

    CPC分类号： C07C253/20 ,  C07C255/50 ,  C07C255/51 ,  C07C255/54

    摘要： Process for preparing nitriles by reacting N-alkylcarboxamides (RCO—NHR1) or ammonium salts of carboxylic acids (RCOO—NH3R1+) or carboxylic acids in the presence of alkylamines or ammonium salts (RCOOH+NH2R1, RCOOH+NH13R1+) respectively, R being an arbitrarily substituted linear or branched C1-C12-alkyl radical, a C3-C12 cycloalkyl radical or an alkenyl, alkynyl or aryl or heteroaryl radical and R1 being an arbitrary substituted, linear or branched C2-C1 alkyl radical, a C3-C12 cycloalkyl radical or an alkenyl or alkynyl radical, with phosphonic anhydrides in the presence of an optional base in an organic solvent at a temperature in the range from −30 to 180° C. In advantageous embodiments, the phosphonic anhydride is a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide of the formula (I)

    摘要翻译： 通过使N-烷基甲酰胺（RCO-NHR 1）或羧酸铵盐（RCOO-NH 3 R 1 +）反应制备腈的方法， ）或羧酸在烷基胺或铵盐的存在下（RCOOH + NH 2 R 1，RCOOH + NH 3 R 1） + ），R是任意取代的直链或支链C 1 -C 12 - 烷基，C 3 - C 12环烷基或链烯基，炔基或芳基或杂芳基，R 1是任意取代的直链或支链C 2 -C 烷基，C 3 -C 12 - 环烷基或链烯基或炔基与膦酸酐在任选的碱存在下反应 在有机溶剂中，在-30至180℃的温度范围内。在有利的实施方案中，膦酸酐是2,4,6-取代的1,3,5,2,4,6-三氧杂三磷杂环己烷2,4 式（I）的6-三氧化物，

    Process for preparing nitriles by elimination reactions
    2.
    发明授权
    Process for preparing nitriles by elimination reactions 有权
    通过消除反应制备腈的方法

    公开(公告)号：US07939688B2

    公开(公告)日：2011-05-10

    申请号：US11996105

    申请日：2006-07-05

    申请人： Andreas Meudt ,  Sven Nerdinger ,  Claudius Boehm

    发明人： Andreas Meudt ,  Sven Nerdinger ,  Claudius Boehm

    IPC分类号： C07C253/20

    CPC分类号： C07C253/20 ,  C07C255/50 ,  C07C255/51 ,  C07C255/54

    摘要： Process for preparing nitriles by reacting N-alkylcarboxamides (RCO—NHR1) or ammonium salts of carboxylic acids (RCOO—NH3R1+) or carboxylic acids in the presence of alkylamines or ammonium salts (RCOOH+NH2R1, RCOOH+NH3R1+), respectively, R being an arbitrarily substituted linear or branched C1-C12-alkyl radical, a C3-C12 cycloalkyl radical or an alkenyl, alkynyl or aryl or heteroaryl radical and R1 being an arbitrary substituted, linear or branched C2-C1 alkyl radical, a C3-C12 cycloalkyl radical or an alkenyl or alkynyl radical, with phosphonic anhydrides in the presence of an optional base in an organic solvent at a temperature in the range from −30 to 180° C. In advantageous embodiments, the phosphonic anhydride is a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide of the formula (I)

    摘要翻译： 在烷基胺或铵盐（RCOOH + NH 2 R 1，RCOOH + NH 3 R 1 +）存在下，通过N-烷基羧酰胺（RCO-NHR1）或羧酸铵盐（RCOO-NH 3 R 1 +）或羧酸反应来制备腈的方法，R为 任意取代的直链或支链C 1 -C 12烷基，C 3 -C 12环烷基或烯基，炔基或芳基或杂芳基，R 1为任意取代的直链或支链C 2 -C 1烷基，C 3 -C 12环烷基 基团或烯基或炔基与膦酸酐在有机溶剂中在任选的碱存在下在-30至180℃的温度下反应。在有利的实施方案中，膦酸酐是2,4,6 式（I）的1,3,5,2,4,6-三氧杂三磷杂环己烷2,4,6-三氧化物

    Method for Producing 2-Formylfuran-4-Boronic Acid by the Metalation of 4-Halofurfural Acetals in the Presence of Suitable Boronic Acid Esters or Anhydrides
    3.
    发明申请
    Method for Producing 2-Formylfuran-4-Boronic Acid by the Metalation of 4-Halofurfural Acetals in the Presence of Suitable Boronic Acid Esters or Anhydrides 审中-公开
    在合适的硼酸酯或酸酐存在下通过4-卤代呋喃醛缩合生产2-甲基呋喃-4-硼酸的方法

    公开(公告)号：US20080188671A1

    公开(公告)日：2008-08-07

    申请号：US11912157

    申请日：2006-05-10

    申请人： Andreas Meudt ,  Sven Nerdinger ,  Michael Erbes ,  William Vogt

    发明人： Andreas Meudt ,  Sven Nerdinger ,  Michael Erbes ,  William Vogt

    IPC分类号： C07F5/02

    CPC分类号： C07F5/025

    摘要： Methods for producing furfural-4-boronic acid by the reaction of furfural acetals (I), which are substituted by halogen in position 4, with boronic acid esters or anhydrides, by the subsequent metalation of compound (I) and the simultaneous or subsequent reaction with a boronic acid ester or anhydride to form an acetal-protected furfural-4-boronic acid ester. This product is subjected to acid hydrolysis to form furfural-4-boronic acid. In the formulae: X represents chlorine, bromine or iodine; R represents a branched, unbranched and/or cyclic, optionally substituted C1-C20 alkyl group, an optionally substituted C6-C12 aryl group or an optionally substituted C3-C8 cycloalkyl group, the two groups R together can form a ring; R′, R″, R′″ independently of one another represent acylic or cyclic, branched or unbranched, optionally substituted C1-C20 alkyl groups, or optionally substituted aryl groups, optionally two of the groups R′, R″ and R′″ together form a ring, or represent additional groups B(OR)3.

    摘要翻译： 通过随后的化合物（I）的金属化和通过化合物（I）的金属化以及同时或随后的反应，通过由位置4的卤素取代的糠醛缩醛（I）与硼酸酯或酸酐反应制备糠醛-4-硼酸的方法 与硼酸酯或酸酐形成缩醛保护的糠醛-4-硼酸酯。 将该产物进行酸水解形成糠醛-4-硼酸。 式中X表示氯，溴或碘; R表示支链，非支链和/或环状的任选取代的C 1 -C 20烷基，任选取代的C 6 -C 20烷基， 芳基或任选取代的C 3 -C 8环烷基，两个基团R一起可以形成环; R'，R“，R”'彼此独立地表示酰基或环状，支链或非支链的任选取代的C 1 -C 20烷基，或任选地 取代的芳基，任选地两个基团R'，R“和R”'一起形成环，或代表另外的基团B（OR）3。

    Method for Producing Aryl Amines, Aryl Ethers and Aryl Thioethers
    5.
    发明申请
    Method for Producing Aryl Amines, Aryl Ethers and Aryl Thioethers 审中-公开
    制备芳基胺，芳基醚和芳基硫醚的方法

    公开(公告)号：US20080306260A1

    公开(公告)日：2008-12-11

    申请号：US11917928

    申请日：2006-06-14

    申请人： Andreas Meudt ,  Sven Nerdinger ,  Bernd Wilhelm Lehnemann ,  Joerg Jung ,  Till Vogel ,  Victor Snieckus

    发明人： Andreas Meudt ,  Sven Nerdinger ,  Bernd Wilhelm Lehnemann ,  Joerg Jung ,  Till Vogel ,  Victor Snieckus

    IPC分类号： C07D295/00 ,  C07C211/43 ,  C07C229/00 ,  C07C39/00 ,  C07F9/02 ,  C07F15/00

    CPC分类号： C07D295/023 ,  C07C41/16 ,  C07C209/10 ,  C07C253/30 ,  C07F9/5022 ,  C07C211/56 ,  C07C211/58 ,  C07C255/58 ,  C07C43/275

    摘要： The invention relates to a method for producing aryl or heteroaryl amines, ethers or thioethers (III) by cross-coupling primary or secondary amities, alcohols or thioalcohols with substituted aryl or heteroaryl compounds (I) in the presence of a Brønsted base and a catalyst or a pre-catalyst containing a) a transition metal, a complex, a salt, or a compound of a transition metal from the group V, Mn, Fe, Co, Ni, Rh, Pd, Ir, Pt, and b) at least one sulfonated phosphane ligand in a solvent or a solvent mixture corresponding to Scheme 1 wherein Hal represents fluorine, chlorine, bromine, iodine, alkoxy, trifluoromethane sulfonate, nonafluorotrimethyl-methane sulfonate, methane sulfonate, 4-nitrobenzene sulfonate, benzene sulfonate, 2-naphthalene sulfonate, 3-nitrobenzene sulfonate, 4-nitrobenzene sulfonate, 4-chlorobenzene sulfonate, 2,4,6-triisopropylbenzene sulfonate or any other sulfonate, and X represents O, S or NR″. The invention also relates to novel phosphane ligands.

    摘要翻译： 本发明涉及通过在布朗斯台德碱和催化剂存在下将伯或仲胺，醇或硫代醇与取代的芳基或杂芳基化合物（I）交联而制备芳基或杂芳基胺，醚或硫醚（III）的方法 或含有a）过渡金属，络合物，盐或来自V族，Mn，Fe，Co，Ni，Rh，Pd，Ir，Pt和b）的过渡金属的化合物的预催化剂在 对应于方案1的溶剂或溶剂混合物中的至少一个磺化膦配体，其中Hal表示氟，氯，溴，碘，烷氧基，三氟甲磺酸盐，九氟三甲基甲磺酸盐，甲磺酸盐，4-硝基苯磺酸盐，苯磺酸盐， 萘磺酸盐，3-硝基苯磺酸盐，4-硝基苯磺酸盐，4-氯苯磺酸盐，2,4,6-三异丙基苯磺酸盐或任何其它磺酸盐，X代表O，S或NR“。 本发明还涉及新的磷烷配体。

    Process for preparing nitriles and isonitriles by dehydration reactions with propanephosphonic anhydrides
    6.
    发明申请
    Process for preparing nitriles and isonitriles by dehydration reactions with propanephosphonic anhydrides 审中-公开
    用丙膦酸酐与脱水反应制备腈和异腈的方法

    公开(公告)号：US20070161813A1

    公开(公告)日：2007-07-12

    申请号：US10586768

    申请日：2005-01-15

    申请人： Andreas Meudt ,  Stefan Scherer ,  Sven Nerdinger

    发明人： Andreas Meudt ,  Stefan Scherer ,  Sven Nerdinger

    IPC分类号： C07C253/20

    CPC分类号： C07C253/20 ,  C07C253/22 ,  C07C291/10 ,  C07C255/50

    摘要： The invention concerns a method for producing: a) nitriles of formula (II) and b) isonitriles of formula (III) by reacting: a) carboxylic acid amides (RCO—NH2), ammonium salts of carboxylic acids (RCOO—NH4+) or carboxylic acids in the presence of ammonia or ammonium salts (RCOOH+NH3, RCOOH+NH4+) or b) formamides (H—CO—NHR) or mixtures of amines with formic acid, with cyclic phosphonic acid anhydrides while eliminating water at a temperature ranging from −30 to +120° C., in which R represents an arbitrarily substituted linear or branched C1-C8 alkyl radical, a C3-C10 cycloalkyl radical, alkenyl radical, alkynyl radical or an aryl radical or heteroaryl radical. As a cyclic phosphonic acid anhydride, a 2,4,6,-substituted 1,3,5,2,4,6 -trioxatriphosphinane-2,4,6-trioxide of formula (I) is advantageously used, in which: x=3, 4 or 5; R′, independent of one another, represents open-chain or branched, saturated or unsaturated, straight-chain C1to C16 alkyl radicals or cyclic C3 to C16 alkyl radicals or aryl or heteroaryl.

    摘要翻译： 本发明涉及一种制备以下方法：a）式（II）腈和b）式（III）的亚硝酸酯：a）羧酸酰胺（RCO-NH 2），羧酸铵盐（RCOO-NH 4 +）或 羧酸在氨或铵盐（RCOOH + NH 3，RCOOH + NH 4 +）或b）甲酰胺（H-CO-NHR）或胺与甲酸的混合物存在下与环状膦酸酐反应，同时在温度范围内除去水 从-30至+ 120℃，其中R表示任意取代的直链或支链C 1 -C 8烷基，C 3 - 环烷基，烯基，炔基或芳基或杂芳基。 作为环状膦酸酐，有利地使用式（I）的2,4,6， - 取代的1,3,5,2,4,6-三氧杂三磷杂环己烷-2,4,6-三氧化物，其中：x = 3,4或5; R'彼此独立地表示直链或支链，饱和或不饱和的直链C 1至C 16烷基或环C 3 C 16 -C 16烷基或芳基或杂芳基。

    METHOD FOR THE PRODUCTION OF BORONIC ACIDS CARRYING CYANOALKYL, CARBOXYL AND AMINOCARBONYL GROUPS AND THEIR DERIVATIVES
    7.
    发明申请
    METHOD FOR THE PRODUCTION OF BORONIC ACIDS CARRYING CYANOALKYL, CARBOXYL AND AMINOCARBONYL GROUPS AND THEIR DERIVATIVES 审中-公开
    生产氰基烷基，羧基和氨基羰基的硼酸及其衍生物的方法

    公开(公告)号：US20090286995A1

    公开(公告)日：2009-11-19

    申请号：US12296292

    申请日：2007-03-01

    申请人： Andreas Meudt ,  Sven Nerdinger ,  Bernd Wilhelm Lehnemann

    发明人： Andreas Meudt ,  Sven Nerdinger ,  Bernd Wilhelm Lehnemann

    IPC分类号： C07F5/02

    CPC分类号： C07F5/025

    摘要： A process for the manufacture of aminocarbonyl boronic acids of formula (IV) by converting the compounds of formula (III) with a Brønsted base Y(OH)n in a solvent or a solvent mixture, in which Z represents an optionally substituted arylene, heteroarylene, alkene, heteroalkene, alkylidene, heteroalkylidene, alkenylidene, heteroalkenylidene, alkynylidene, arylalkylene, heteroarylalkylene, arylheteroalkylene, heteroarylheteroalkylene, alkylheteroarylene, heteroalkylheteroarylene, or alkylarylene group; Y represents a metal or ammonium cation of valence n with 0

    摘要翻译： 通过用溶剂或溶剂混合物中的布朗斯台德Y（OH）n转化式（III）化合物来制备式（IV）的氨基羰基硼酸的方法，其中Z表示任选取代的亚芳基，亚杂芳基 亚烷基，亚杂烷基，亚烯基，杂亚烷基，亚炔基，芳基亚烷基，杂芳基亚烷基，芳基杂亚烷基，杂芳基亚烷基，烷基亚芳基，杂烷基亚芳基或烷基亚芳基。 Y表示0