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1.发明申请USE OF AN ANTI-alpha-SYNUCLEIN ANTIBODY TO DIAGNOSE AN ELEVATED LEVEL OF alpha-SYNUCLEIN IN THE BRAIN 审中-公开使用抗α-SYNUCLEIN抗体来诊断脑中α-SYNUCLEIN的高度水平公开(公告)号：US20140295465A1
公开(公告)日：2014-10-02
申请号：US14355743
申请日：2012-10-29
申请人： Andreas Weihofen , Thomas Engber , Jan Grimm
发明人： Andreas Weihofen , Thomas Engber , Jan Grimm
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , C07K16/28 , C07K2317/24 , G01N2800/2821
摘要： This disclosure relates to the use of anti-α-synuclein antibody to diagnose an elevated level of α-synuclein in the brain. Specifically, the disclosure relates to the method of assessing the levels of α-synuclein in a blood plasma or CSF following administration to the test subject of an anti-α-synuclein antibody or antigen-binding fragment thereof, which can bind α-synuclein with sufficient activity to alter the net efflux of α-synuclein from brain to blood, or from brain to CSF.
摘要翻译： 本公开涉及抗α-突触核蛋白抗体用于诊断脑中α-突触核蛋白水平升高的用途。 具体地说，本公开内容涉及在给予受试对象的抗α-突触核蛋白抗体或其抗原结合片段的血浆或CSF中的α-突触核蛋白水平的评估方法，其可以将α-synuclein与 足够的活性来改变α-突触核蛋白从脑到血，或从脑到CSF的净流出。
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2.发明申请公开(公告)号：US20150315267A1
公开(公告)日：2015-11-05
申请号：US14650200
申请日：2013-12-06
申请人： Thierry BUSSIERE , Paul H. WEINREB , Thomas ENGBER , Kenneth RHODES , Joseph ARNDT , Fang QIAN , Robert W. DUNSTAN , Shailendra PATEL , BIOGEN IDEC INTERNATIONAL NEUROSCIENCE GMBH , Neurimmune Holding AG
发明人： Thierry Bussiere , Paul H. Weinreb , Thomas Engber , Kenneth Rhodes , Joseph Arndt , Fang Qian , Robert W. Dunstan , Shailendra Patel , Jan Grimm , Marcel Maier
CPC分类号： C07K16/18 , A61K51/1018 , A61K51/1093 , A61K2039/505 , A61K2039/545 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： This disclosure relates to the use of anti-Aβ antibody or antigen-binding fragment thereof to reduce brain amyloid plaques, or minimizes the occurrence of microhemorrhage during chronic dosing of an anti-Aβ antibody or antigen-binding fragment thereof. For example, the disclosure relates to the method of reducing brain amyloid plaques, comprising administering to a subject an anti-Aβ antibody or antigen-binding fragment thereof that binds to the same epitope as BIIB037 antibody, wherein the administration can reduce amyloid plaques in brain without affecting vascular amyloid, and wherein BIIB037 antibody binds to an epitope comprising amino acids 3-6 of Aβ.
摘要翻译： 本公开涉及抗A＆bgr的用途; 抗体或其抗原结合片段以减少脑淀粉样蛋白斑块，或者在慢性给药抗A药物期间最小化微出血的发生; 抗体或其抗原结合片段。 例如，本公开涉及减少脑淀粉样蛋白斑块的方法，包括向受试者施用抗Aβ抗体; 抗体或抗原结合片段，其结合与BIIB037抗体相同的表位，其中所述施用可以减少脑中的淀粉样蛋白斑，而不影响血管淀粉样蛋白，并且其中BIIB037抗体结合包含A＆bgr的氨基酸3-6的表位。
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3.发明申请Methods and compositions for treating disorders involving excitotoxicity 审中-公开用于治疗涉及兴奋性毒性的疾病的方法和组合物公开(公告)号：US20070254364A1
公开(公告)日：2007-11-01
申请号：US11725144
申请日：2007-03-16
CPC分类号： A61K38/17 , A61K38/1709
摘要： It is shown here that hedgehog polypeptides possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons and other neurons which are sensitive to exotoxicity.
摘要翻译： 这里显示，刺猬多肽具有超出表型规范的新活性。 使用来自胚胎第14.5天（E14.5）大鼠腹侧中脑的培养物，我们显示刺猬也对多巴胺能神经元和其他对外毒素敏感的神经元营养不良。
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4.发明申请Methods and compositions for treating disorders involving excitotoxicity 审中-公开用于治疗涉及兴奋性毒性的疾病的方法和组合物公开(公告)号：US20080221037A1
公开(公告)日：2008-09-11
申请号：US12082946
申请日：2008-04-14
CPC分类号： A61K38/17 , A61K38/1709
摘要： It is shown here that hedgehog polypeptides possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons and other neurons which are sensitive to exotoxicity.
摘要翻译： 这里显示，刺猬多肽具有超出表型规范的新活性。 使用来自胚胎第14.5天（E14.5）大鼠腹侧中脑的培养物，我们显示刺猬也对多巴胺能神经元和其他对外毒素敏感的神经元营养不良。
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