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    Potassium channel interactors and uses therefor
    3.
    发明授权
    Potassium channel interactors and uses therefor 有权
    钾通道相互作用及其用途

    公开(公告)号：US06369197B1

    公开(公告)日：2002-04-09

    申请号：US09298731

    申请日：1999-04-23

    申请人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wengian An

    发明人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wengian An

    IPC分类号： C07K1400

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。

    Potassium channel interactors and uses therefor
    5.
    发明授权
    Potassium channel interactors and uses therefor 有权
    钾通道相互作用及其用途

    公开(公告)号：US06689581B1

    公开(公告)日：2004-02-10

    申请号：US09350614

    申请日：1999-07-09

    申请人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    发明人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    IPC分类号： C12N1512

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。

    Nucleic acid molecules encoding potassium channel interactors and uses therefor
    6.
    发明授权
    Nucleic acid molecules encoding potassium channel interactors and uses therefor 有权
    编码钾通道相互作用的核酸分子及其用途

    公开(公告)号：US06361971B1

    公开(公告)日：2002-03-26

    申请号：US09399913

    申请日：1999-09-21

    申请人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    发明人： Kenneth Rhodes ,  Maria Betty ,  Huai-Ping Ling ,  Wenqian An

    IPC分类号： C12N1512

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PCIP nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PCIP gene has been introduced or disrupted. The invention still further provides isolated PCIP proteins, fusion proteins, antigenic peptides and anti-PCIP antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，指定的PCIP核酸分子，其编码结合钾通道的蛋白质并调节钾通道介导的活性。 本发明还提供了反义核酸分子，含有PCIP核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了PCIP基因的非人转基因动物。 本发明还进一步提供了分离的PCIP蛋白，融合蛋白，抗原肽和抗PCIP抗体。 还提供了利用本发明组合物的诊断方法。