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公开(公告)号:US08455003B2
公开(公告)日:2013-06-04
申请号:US13452337
申请日:2012-04-20
申请人: Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
发明人: Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
CPC分类号: A61K31/704 , A61J3/00 , A61K9/00 , A61K9/146 , A61K9/1635 , A61K49/00
摘要: A composition for chemoembolotherapy of solid tumors comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
摘要翻译: 用于实体肿瘤化学疗法的组合物包括水不溶性水溶胀性合成阴离子聚合物颗粒,并在其中吸收蒽环类。 适合地,聚合物是基于聚(乙烯醇)的聚合物,并且药物是多柔比星。
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公开(公告)号:US08221793B2
公开(公告)日:2012-07-17
申请号:US12210573
申请日:2008-09-15
申请人: Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
发明人: Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
CPC分类号: A61K31/704 , A61J3/00 , A61K9/00 , A61K9/146 , A61K9/1635 , A61K49/00
摘要: A composition for chemoembolotherapy of solid tumors comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
摘要翻译: 用于实体肿瘤化学疗法的组合物包括水不溶性水溶胀性合成阴离子聚合物颗粒,并在其中吸收蒽环类。 适合地,聚合物是基于聚(乙烯醇)的聚合物,并且药物是多柔比星。
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公开(公告)号:US07442385B2
公开(公告)日:2008-10-28
申请号:US11434274
申请日:2006-05-16
申请人: Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
发明人: Andrew Lennard Lewis , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Fajardo Gonzalez
CPC分类号: A61K31/704 , A61J3/00 , A61K9/00 , A61K9/146 , A61K9/1635 , A61K49/00
摘要: A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
摘要翻译: 用于实体肿瘤化学疗法的组合物包括水不溶性水溶胀性合成阴离子聚合物颗粒,并在其中吸收蒽环类。 适合地,聚合物是基于聚(乙烯醇)的聚合物,并且药物是多柔比星。
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公开(公告)号:US20090022804A1
公开(公告)日:2009-01-22
申请号:US12210573
申请日:2008-09-15
申请人: Andrew Lennard LEWIS , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Gonzales Fajardo
发明人: Andrew Lennard LEWIS , Peter William Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Victoria Gonzales Fajardo
IPC分类号: A61K9/14 , A61K31/704 , A61P7/00
CPC分类号: A61K31/704 , A61J3/00 , A61K9/00 , A61K9/146 , A61K9/1635 , A61K49/00
摘要: A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
摘要翻译: 用于实体肿瘤化学疗法的组合物包括水不溶性水溶胀性合成阴离子聚合物颗粒,并在其中吸收蒽环类。 适合地,聚合物是基于聚(乙烯醇)的聚合物,并且药物是多柔比星。
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公开(公告)号:US20060204583A1
公开(公告)日:2006-09-14
申请号:US11434274
申请日:2006-05-16
申请人: Andrew Lewis , Peter Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Fajardo Gonzalez
发明人: Andrew Lewis , Peter Stratford , Simon Leppard , Pedro Garcia , Brenda Hall , Maria Fajardo Gonzalez
IPC分类号: A61K31/704 , A61K9/14
CPC分类号: A61K31/704 , A61J3/00 , A61K9/00 , A61K9/146 , A61K9/1635 , A61K49/00
摘要: A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
摘要翻译: 用于实体肿瘤化学疗法的组合物包括水不溶性水溶胀性合成阴离子聚合物颗粒,并在其中吸收蒽环类。 适合地,聚合物是基于聚(乙烯醇)的聚合物,并且药物是多柔比星。
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公开(公告)号:US20060165804A1
公开(公告)日:2006-07-27
申请号:US10528829
申请日:2003-09-23
申请人: Andrew Lewis , Richard Redman , Pedro Garcia
发明人: Andrew Lewis , Richard Redman , Pedro Garcia
CPC分类号: A61K9/1641
摘要: Particulate embolotherapeutic compositions are described in which the particles comprise a matrix polymer expressing at surfaces available for interaction with biological molecules or, usually, blood cells, express zwitterionic groups, usually phosphoryl choline groups. The particles have suitable size and compressibility, for instance controlled by controlling the water content, for use in embolotherapy, by administration using catheters or hypodermic needles. The matrix polymer may be crosslinked. Preferably the particles are spherical. Examples are crosslinked polyvinylalcohol matrices coated with a crosslinkable copolymer formed of 2-methacryloyloxyethyl-2′-trimethylammoniumethyl phosphate inner salt with nonionic and crosslinkable comonomers. The coating is stabilised by crosslinking after coating from an organic solvent solution.
摘要翻译: 描述了颗粒剂治疗组合物,其中颗粒包含在可用于与生物分子相互作用的表面上表达的基质聚合物,或通常为血细胞,表达两性离子基团,通常为磷酰胆碱基团。 颗粒具有合适的尺寸和压缩性,例如通过使用导管或皮下注射针施用来控制水分含量,用于电疗法。 基质聚合物可以是交联的。 优选地,颗粒是球形的。 实例是涂覆有由2-甲基丙烯酰氧基乙基-2'-三甲基铵乙基磷酸盐内盐与非离子和交联共聚单体形成的可交联共聚物的交联聚乙烯醇基质。 通过在从有机溶剂溶液中涂布之后,通过交联来稳定涂层。
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公开(公告)号:US5893827A
公开(公告)日:1999-04-13
申请号:US105386
申请日:1998-06-26
申请人: Ramon E. Jaquez , Pedro Garcia
发明人: Ramon E. Jaquez , Pedro Garcia
摘要: In contrast to exiting flow-restricting penis encircling rings applying a single selected pressure as determined by their size and construction material, there is provided a pressure-applying device to counter venous leakage having an operating mode of making available a range of pressures so that a user can select a pressure from the range, prior use of the device, as might be determined from trial and error that is most effective for his artery system, all to the end of maintaining an erectile penis condition.
摘要翻译: 与通过其尺寸和结构材料确定的施加单个选定压力的限流阴茎环形环相比,提供了一种用于抵抗静脉泄漏的压力施加装置,其具有使得可获得一定压力范围的操作模式,使得 用户可以从该范围内选择压力,先前使用该装置,这可能是由对他的动脉系统最有效的试验和误差确定的,一直到维持阴茎勃起状态。
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