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    Anionic-cationic polyion complexes comprising zwitterionic monomer component
    6.
    发明授权
    Anionic-cationic polyion complexes comprising zwitterionic monomer component 有权
    包含两性离子单体组分的阴离子阳离子聚阳离子络合物

    公开(公告)号：US06524569B1

    公开(公告)日：2003-02-25

    申请号：US09831753

    申请日：2001-05-14

    申请人： Peter William Stratford ,  Jane Louise Court ,  Andrew Lennard Lewis

    发明人： Peter William Stratford ,  Jane Louise Court ,  Andrew Lennard Lewis

    IPC分类号： A61K3174

    CPC分类号： C08K9/12 ,  C08L57/04 ,  C08L57/12 ,  C08L2666/04

    摘要： A polyion complex (PIC) is formed of an anionic soluble polymer formed from ethylenically unsaturated monomers including at least one anionic or monomer and a cationic soluble polymer formed from ethylenically unsaturated monomer including at least one cationic monomer, in which the monomers used to form at least one of the polymers comprise a zwitterionic monomer and in which the monomers used to form at least one of the polymers include non-ionic monomer, preferably C1-24 alkyl(meth)acrylate, in which the overall ratio of anionic groups to cationic groups in the PIC is in the range 1.5:1 to 1:1.5, and in which the polymers are combined in ratios to provide a PIC in which there are units derived from zwitterionic monomer in an amount in the range 1 to 70 mole % based on total monomer derived units in the PIC and there are units derived from non-ionic monomer in an amount in the range 0 to 60 mole % based on total monomer derived units in the PIC. The PIC is preferably swollen in water and is a flowable gel. The zwitterionic monomer is preferably 2-(methacyloyloxyethyl)-2′-(trimethylammoniumethyl)phosphate inner salt.

    摘要翻译： 聚阴离子络合物（PIC）由阴离子可溶性聚合物形成，其由包含至少一种阴离子或单体的烯属不饱和单体和由包含至少一种阳离子单体的烯属不饱和单体形成的阳离子可溶性聚合物形成，其中用于在 至少一种聚合物包含两性离子单体，其中用于形成至少一种聚合物的单体包括非离子单体，优选C 1-4烷基（甲基）丙烯酸酯，其中阴离子基团与阳离子基团的总比例 在PIC中的范围为1.5:1至1:1.5，其中聚合物的比例组合以提供PIC，其中存在衍生自两性离子单体的单元，其量为1至70摩尔％，基于 PIC中的单体衍生单元总数，并且源自非离子单体的单元的量为基于PIC中单体衍生单元的0至60摩尔％。 PIC优选在水中溶胀并且是可流动的凝胶。 两性离子单体优选为2-（甲基氰基乙氧基乙基）-2' - （三甲基铵乙基）磷酸酯内盐。

    MICROSPHERES FOR TREATMENT OF BRAIN TUMORS
    8.
    发明申请
    MICROSPHERES FOR TREATMENT OF BRAIN TUMORS 有权
    用于治疗脑肿瘤的微环境

    公开(公告)号：US20100160246A1

    公开(公告)日：2010-06-24

    申请号：US12089797

    申请日：2007-10-10

    申请人： Andrew Lennard Lewis ,  Yiqing Tang ,  Peter William Stratford

    发明人： Andrew Lennard Lewis ,  Yiqing Tang ,  Peter William Stratford

    IPC分类号： A61K31/704 ,  A61P35/00 ,  A61K31/4745

    CPC分类号： A61K9/0085 ,  A61K9/16 ,  A61K9/1635 ,  A61K31/14 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/734 ,  C08B37/0006

    摘要： There is provided a new use of microspheres comprising a water-insoluble, water-swellable polymer which is anionically charged at pH7, and electrostatically associated with the polymer, in releasable form, a cationically charged chemotherapeutic agent, in the manufacture of a composition for use in the treatment of a brain tumour, wherein in the treatment the composition is introduced into the brain and the chemotherapeutic agent is released from the microspheres, wherein the microspheres, when equilibrated in water at 37° C., comprise at least 40 wt % water based on weight of polymer plus water. Compositions comprising the microspheres and methods for the treatment of brain tumours are also provided.

    摘要翻译： 提供了新的使用的微球，其包含水不溶性的水溶胀性聚合物，其在pH7下被阴离子充电，并且与可聚合物静电相关的聚合物与阳离子电荷的化学治疗剂在制造用于使用的组合物中 在治疗脑肿瘤中，其中在治疗中将组合物引入脑中，并且化学治疗剂从微球释放，其中当在37℃的水中平衡时，微球包含至少40重量％的水 基于聚合物加水的重量。 还提供了包含微球的组合物和治疗脑肿瘤的方法。

    Microspheres for treatment of brain tumors
    9.
    发明授权
    Microspheres for treatment of brain tumors 有权
    用于治疗脑肿瘤的微球

    公开(公告)号：US08691791B2

    公开(公告)日：2014-04-08

    申请号：US12089797

    申请日：2007-10-10

    申请人： Andrew Lennard Lewis ,  Yiqing Tang ,  Peter William Stratford

    发明人： Andrew Lennard Lewis ,  Yiqing Tang ,  Peter William Stratford

    IPC分类号： A61K9/16 ,  A61K31/734 ,  C08B37/04 ,  C08B37/00

    CPC分类号： A61K9/0085 ,  A61K9/16 ,  A61K9/1635 ,  A61K31/14 ,  A61K31/4745 ,  A61K31/704 ,  A61K31/734 ,  C08B37/0006

    摘要： There is provided a new use of microspheres comprising a water-insoluble, water-swellable polymer which is anionically charged at pH7, and electrostatically associated with the polymer, in releasable form, a cationically charged chemotherapeutic agent, in the manufacture of a composition for use in the treatment of a brain tumor, wherein in the treatment the composition is introduced into the brain and the chemotherapeutic agent is released from the microspheres, wherein the microspheres, when equilibrated in water at 37° C., comprise at least 40 wt % water based on weight of polymer plus water. Compositions comprising the microspheres and methods for the treatment of brain tumors are also provided.

    摘要翻译： 提供了新的使用的微球，其包含水不溶性的水溶胀性聚合物，其在pH7下被阴离子充电，并且与可聚合物静电相关的聚合物与阳离子电荷的化学治疗剂在制造用于使用的组合物中 在治疗脑肿瘤中，其中在治疗中将组合物引入脑中，并且化学治疗剂从微球释放，其中当在37℃的水中平衡时，微球包含至少40重量％的水 基于聚合物加水的重量。 还提供了包含微球的组合物和治疗脑肿瘤的方法。