摘要:
Particulate embolotherapeutic compositions are described in which the particles comprise a matrix polymer expressing at surfaces available for interaction with biological molecules or, usually, blood cells, express zwitterionic groups, usually phosphoryl choline groups. The particles have suitable size and compressibility, for instance controlled by controlling the water content, for use in embolotherapy, by administration using catheters or hypodermic needles. The matrix polymer may be crosslinked. Preferably the particles are spherical. Examples are crosslinked polyvinylalcohol matrices coated with a crosslinkable copolymer formed of 2-methacryloyloxyethyl-2′-trimethylammoniumethyl phosphate inner salt with nonionic and crosslinkable comonomers. The coating is stabilised by crosslinking after coating from an organic solvent solution.
摘要:
A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
摘要:
The present application refers to the use of cells, e.g. mesenchymal stem cells or mesenchymal stromal cells, or any further suitable cell, encoding and secreting at least GLP-1, or a fragment or variant thereof, and preferably additionally secreting VEGF, for the prevention, treatment and/or amelioration of vascular diseases, wherein the cells, encoding and secreting at least GLP-1, or a fragment or variant thereof, and preferably additionally secreting VEGF, are encapsulated in a (spherical) microcapsule to prevent a response of the immune system of the patient to be treated. The present application also refers to the use of these (spherical) microcapsule(s) or of a pharmaceutical composition containing these cells or (spherical) microcapsule(s) for the prevention, treatment and/or amelioration of vascular diseases.
摘要:
A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.
摘要:
A method for tilling needleless injector capsules with liquid drug, whereby dissolved gas within the drug is replaced by a less soluble gas in order to reduce the inclusion of gas bubbles, or to prevent the growth of bubbles during storage and thereby prevent breakage of the capsules.
摘要:
A system and method for imaging a three-dimensional scene having one or more objects. The system includes a light source, a detector array, a timing circuit, an inertial guidance system and a processor connected to the timing circuit and the inertial guidance system. The light source generates an optical pulse and projects the optical pulse on an object so that it is reflected as a reflected pulse. The detector array includes a plurality of detectors, wherein the detectors are oriented to receive the reflected pulse. The timing circuit determines when the reflected pulse reached detectors on the detector array. The inertial guidance system measures angular velocity and acceleration. The processor forms a composite image of the three-dimensional scene as a function of camera position and range to objects in the three-dimensional scene.
摘要:
A system and method for pooling of investment funds enables a multinational corporation to cause its employee benefit plans from multiple international jurisdictions to pool their investments into a single entity, which invests in various financial products including exchange traded debt and equity securities as well as other securities. The entity is preferably structured as an offshore pooled vehicle, which may have one or more sub-funds that vary by investment objective and/or eligible investments. Each pooled vehicle is preferably organized as an Irish CCF, a Luxembourg FCP, a Dutch FGR or other tax-transparent vehicle. The investors in such pooled vehicles and sub-funds are preferably the employee benefit plans of the multinational corporation. A banking or trust organization that is duly qualified and licensed to act under the laws of the applicable jurisdiction as a management company for the pooled vehicles will act on behalf of the applicable pooled vehicle.
摘要:
The present invention relates to conjugates of biologically active compounds, preferably therapeutically active compounds, with polymeric moieties having low polydispersity, as well as controlled polymerisation processes for producing the conjugates. An initiation for a controlled radical polymerisation process comprises a biologically active, usually therapeutically active, moiety and the monomer includes zwitterionic monomer for instance 2-methacryloyloxyethyl-2′-trimethylammonium ethyl phosphate inner salt. The process allows close control of the molecular weight and polydispersity of the polymeric moiety and the possibility of optimizing the delivery characteristics of the active agent.
摘要:
The present invention relates to an apparatus for use in geophysical surveying. Geophysical surveying typically involves stimulating an area of interest with a seismic source (204) and detecting the response in a sensor array. The application describes a fiber optic distributed sensing apparatus having a source (112) of electromagnetic radiation for repeatedly launching interrogating electromagnetic radiation into an optic fiber (104) deployed in said of area interest, a sampling detector (116) for sampling radiation back-scattered from the fiber; and a processor (108) arranged to process the back-scattered radiation to provide, for each of a plurality of longitudinal sensing portions of optic fiber, an indication of any incident acoustic signals affecting that sensing portion. The sampling detector is arranged to acquire a plurality of diversity samples for each said longitudinal sensing portion. The processor is configured process the diversity samples in diversity channels to determine a measurement signal indicative of any acoustic disturbance; correlate the measurement signal from each channel with a signal indicative of the seismic stimulus applied; and combine the correlated measurement signals to provide an overall measurement signal for the longitudinal sensing portion. The processor may apply a quality metric to the correlated data before performing the combination based on the quality metric. By correlating the individual diversity channels with the stimulus signal prior to performing the analysis of the measurement signal for a particular longitudinal section of optic fiber, the signal to noise ratio can be improved.