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公开(公告)号：US08318902B2
公开(公告)日：2012-11-27
申请号：US12377221
申请日：2007-08-10
申请人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
发明人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
IPC分类号： A61K38/17
摘要： A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
摘要翻译： 一种制备复合生物材料的方法，包括：提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽中的一种或多种的第一基本上固体的组分，以及任选的无机 所述组分至少具有多孔的表面部分; 提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽，液体载体和任选的无机材料中的一种或多种的流体组合物; 使所述流体组合物与所述第一组分的所述多孔表面部分接触; 将所述流体组合物冷却至液体载体转变成多个固体晶体或颗粒的温度; 通过升华和/或蒸发去除多个固体晶体或颗粒中的至少一些。
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公开(公告)号：US20100248368A1
公开(公告)日：2010-09-30
申请号：US12377221
申请日：2007-08-10
申请人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
发明人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
IPC分类号： C12N5/071
摘要： A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
摘要翻译： 一种制备复合生物材料的方法，包括：提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽中的一种或多种的第一基本上固体的组分，以及任选的无机 所述组分至少具有多孔的表面部分; 提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽，液体载体和任选的无机材料中的一种或多种的流体组合物; 使所述流体组合物与所述第一组分的所述多孔表面部分接触; 将所述流体组合物冷却至液体载体转变成多个固体晶体或颗粒的温度; 通过升华和/或蒸发去除多个固体晶体或颗粒中的至少一些。
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公开(公告)号：US20090022771A1
公开(公告)日：2009-01-22
申请号：US11908045
申请日：2006-03-06
IPC分类号： A61F2/28 , A61K31/726 , A61P19/00 , B29C67/20
CPC分类号： A61L27/46 , A61L27/56 , A61L2430/02
摘要： A process for the preparation of a composite biomaterial comprising an inorganic material and an organic material, the process comprising: (a) providing a first slurry composition comprising a liquid carrier, an inorganic material and an organic material; (b) providing a mould for the slurry; (c) depositing the slurry in the mould; (d) cooling the slurry deposited in the mould to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; (e) removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation to leave a porous composite material comprising an inorganic material and an organic material; and (f) removing the material from the mould.
摘要翻译： 一种制备包含无机材料和有机材料的复合生物材料的方法，所述方法包括：（a）提供包含液体载体，无机材料和有机材料的第一浆料组合物; （b）为浆料提供模具; （c）将浆料沉积在模具中; （d）将沉积在模具中的浆料冷却至液体载体转变成多个固体晶体或颗粒的温度; （e）通过升华和/或蒸发除去多个固体晶体或颗粒中的至少一些，以留下包含无机材料和有机材料的多孔复合材料; 和（f）从模具中取出材料。
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公开(公告)号：US20120294925A1
公开(公告)日：2012-11-22
申请号：US13482640
申请日：2012-05-29
CPC分类号： A61L27/46 , A61L27/56 , A61L2430/02
摘要： A process for the preparation of a composite biomaterial comprising an inorganic material and an organic material, the process comprising: (a) providing a first slurry composition comprising a liquid carrier, an inorganic material and an organic material; (b) providing a mould for the slurry; (c) depositing the slurry in the mould; (d) cooling the slurry deposited in the mould to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; (e) removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation to leave a porous composite material comprising an inorganic material and an organic material; and (f) removing the material from the mould.
摘要翻译： 一种制备包含无机材料和有机材料的复合生物材料的方法，所述方法包括：（a）提供包含液体载体，无机材料和有机材料的第一浆料组合物; （b）为浆料提供模具; （c）将浆料沉积在模具中; （d）将沉积在模具中的浆料冷却至液体载体转变成多个固体晶体或颗粒的温度; （e）通过升华和/或蒸发除去多个固体晶体或颗粒中的至少一些，以留下包含无机材料和有机材料的多孔复合材料; 和（f）从模具中取出材料。
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公开(公告)号：US06644535B2
公开(公告)日：2003-11-11
申请号：US09860703
申请日：2001-05-18
申请人： Jeremy C. Wallach , Lorna J. Gibson
发明人： Jeremy C. Wallach , Lorna J. Gibson
IPC分类号： B21D3900
CPC分类号： B21F27/128 , B23K11/008 , B23K2101/045 , Y10T428/24058 , Y10T428/24174 , Y10T428/24636
摘要： A structural material includes a plurality of discrete, interwoven wires disposed between and fastened to two solid face sheets. Each of the plurality of wires further includes at least two points of contact with each of the two face sheets. Methods for fabricating the aforementioned structural material include an automated methodology for fabricating a relatively inexpensive truss core sandwich panel.
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