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公开(公告)号：US08318902B2
公开(公告)日：2012-11-27
申请号：US12377221
申请日：2007-08-10
申请人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
发明人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
IPC分类号： A61K38/17
摘要： A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
摘要翻译： 一种制备复合生物材料的方法，包括：提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽中的一种或多种的第一基本上固体的组分，以及任选的无机 所述组分至少具有多孔的表面部分; 提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽，液体载体和任选的无机材料中的一种或多种的流体组合物; 使所述流体组合物与所述第一组分的所述多孔表面部分接触; 将所述流体组合物冷却至液体载体转变成多个固体晶体或颗粒的温度; 通过升华和/或蒸发去除多个固体晶体或颗粒中的至少一些。
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2.发明申请Composite biomaterials comprising calcium phospate materials, collagen and glycosaminoglycans 有权复合生物材料包括钙磷酸盐材料，胶原和糖胺聚糖公开(公告)号：US20070134285A1
公开(公告)日：2007-06-14
申请号：US10595587
申请日：2004-10-28
申请人： Andrew Lynn , Ruth Cameron , Serena Best , William Bonfield
发明人： Andrew Lynn , Ruth Cameron , Serena Best , William Bonfield
CPC分类号： A61L27/28 , A61C8/0006 , A61L24/0084 , A61L27/46
摘要： A process for the production of a composite material comprising collagen, brushite and one or more glycosaminoglycans, said process comprising the steps of providing an acidic aqueous solution comprising collagen, a calcium source and a phosphorous source and one or more glycosaminoglycans, and precipitating the collagen, the brushite and the one or more glycosaminoglycans together from the aqueous solution to form a triple co-precipitate.
摘要翻译： 一种生产复合材料的方法，该复合材料包括胶原蛋白，褐铁矿和一种或多种糖胺聚糖，所述方法包括以下步骤：提供包含胶原蛋白，钙源和磷源和一种或多种糖胺聚糖的酸性水溶液，并沉淀胶原蛋白 ，水凝胶和一种或多种糖胺聚糖一起从水溶液中形成三重共沉淀物。
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公开(公告)号：US06409164B1
公开(公告)日：2002-06-25
申请号：US09561468
申请日：2000-04-28
IPC分类号： B65H334
CPC分类号： B65H3/34 , B65H3/56 , B65H2301/42322
摘要： A pile restrictor includes a restrictor body and a restricting blade attached to the body, the restricting blade being adjustable angularly with respect to the body during an operating mode of a sheet feeder. The present invention also provides a pile feed device having a front guide and at least one pile restrictors, each of the pile restrictors connected to the front guide and including a body and a restricting blade attached to the body, the blade being adjustable angularly with respect to the body during the operating mode. Also disclosed is a method of restricting a sheet pile comprising the steps of placing a pile of sheets in a feeder so that the nose of the pile is restricted by a restrictor; and adjusting an angle of the restrictor furing operation of the feeder.
摘要翻译： 桩限制器包括限制器主体和附接到主体的限制刀片，限制刀片在片材进给器的操作模式期间相对于身体成角度地调节。 本发明还提供了一种具有前引导件和至少一个桩限制器的送料装置，每个桩限制器连接到前引导件并且包括主体和附接到主体的限制刀片，刀片可相对于 在运行模式下对身体。 还公开了一种限制片材桩的方法，包括以下步骤：将一堆片材放置在进料器中，使得绒头的鼻部受限制器限制; 并且调节进料器的限流器的磨合操作的角度。
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公开(公告)号：US20110009872A1
公开(公告)日：2011-01-13
申请号：US12740085
申请日：2008-10-27
申请人： Vanisha Mistry , Tim Mead , Andrew Lynn
发明人： Vanisha Mistry , Tim Mead , Andrew Lynn
IPC分类号： A61B17/56
CPC分类号： A61F2/4618 , A61F2/4603 , A61F2002/3009 , A61F2002/30601 , A61F2002/30617 , A61F2002/4627 , A61F2002/4693 , A61F2250/0091 , A61F2250/0097
摘要： An implant delivery device (10) comprises a barrel (20), a plunger (30) and an inner sleeve (130) which comprises material stress means (140). The plunger is adapted to fit into a central bore of the inner sleeve in a sliding relationship and the inner sleeve in turn is adapted to fit into the bore of the barrel also in a sliding relationship. An alternative embodiment of the device generally comprises a barrel (20) and plunger (30) and an implant (100) loaded within the barrel, and a column of liquid (110) located proximally behind the implant. A user depressing plunger exerts a compression force on liquid, which is transferred onto the implant and the implant moves distally along the barrel toward the distal end (50).
摘要翻译： 植入物输送装置（10）包括筒（20），柱塞（30）和内套筒（130），其包括材料应力装置（140）。 柱塞适于以滑动关系装配到内套筒的中心孔中，并且内套筒又适于与滑动关系配合到筒的孔中。 装置的替代实施例通常包括筒体（20）和柱塞（30）以及装载在筒体内的植入物（100）和位于植入物后面的液体列（110）。 用户按压柱塞对液体施加压缩力，液体被转移到植入物上，并且植入物沿着镜筒远离远端（50）移动。
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公开(公告)号：US20100248368A1
公开(公告)日：2010-09-30
申请号：US12377221
申请日：2007-08-10
申请人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
发明人： Andrew Lynn , William Bonfield , Zachary D. Wissner-Gross , Brendan A. Harley , Ioannis V. Yannas , Lorna J. Gibson
IPC分类号： C12N5/071
摘要： A process for the preparation of a composite biomaterial comprising: providing a first substantially solid component comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and optionally an inorganic material, said component having at least a surface portion that is porous; providing a fluid composition comprising one or more of collagen, a glycosaminoglycan, albumin, hyaluronan, chitosan, and synthetic polypeptides comprising a portion of the polypeptide sequence of collagen, and a liquid carrier, and optionally an inorganic material; contacting said fluid composition with said porous surface portion of said first component; cooling said fluid composition to a temperature at which the liquid carrier transforms into a plurality of solid crystals or particles; removing at least some of the plurality of solid crystals or particles by sublimation and/or evaporation.
摘要翻译： 一种制备复合生物材料的方法，包括：提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽中的一种或多种的第一基本上固体的组分，以及任选的无机 所述组分至少具有多孔的表面部分; 提供包含胶原，糖胺聚糖，白蛋白，透明质酸，壳聚糖和包含胶原多肽序列的一部分的合成多肽，液体载体和任选的无机材料中的一种或多种的流体组合物; 使所述流体组合物与所述第一组分的所述多孔表面部分接触; 将所述流体组合物冷却至液体载体转变成多个固体晶体或颗粒的温度; 通过升华和/或蒸发去除多个固体晶体或颗粒中的至少一些。
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6.发明授权公开(公告)号：US06655681B1
公开(公告)日：2003-12-02
申请号：US09662277
申请日：2000-09-14
IPC分类号： B65H2904
CPC分类号： B65H39/02 , B65H2301/4321 , B65H2403/41 , B65H2403/47 , B65H2403/722 , B65H2511/10 , B65H2511/15 , B65H2220/01 , B65H2220/04 , B65H2220/02 , B65H2220/11
摘要： A sheet material conveying apparatus includes a plurality of pockets, each pocket including a setting device for adjusting a height of the pocket when the pocket is stationary so as to define a set height. A sheet delivery section delivers sheet material into the pockets and a release station for releases the sheet material from the pockets. A reset station automatically resets the pockets to the set height. A method and a sheet material pocket are also provided.
摘要翻译： 片材输送装置包括多个袋，每个袋包括用于当袋静止时调节袋的高度以便限定设定高度的调节装置。 片材输送部分将片材输送到袋中，以及释放站，用于从袋中释放片材。 复位站自动将凹槽重置为设定高度。 还提供了一种方法和片材袋。
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7.发明授权Composite biomaterials comprising calcium phospate materials, collagen and glycosaminoglycans 有权复合生物材料包括钙磷酸盐材料，胶原和糖胺聚糖公开(公告)号：US07780994B2
公开(公告)日：2010-08-24
申请号：US10595587
申请日：2004-10-28
申请人： Andrew Lynn , Ruth Cameron , Serena Best , William Bonfield
发明人： Andrew Lynn , Ruth Cameron , Serena Best , William Bonfield
CPC分类号： A61L27/28 , A61C8/0006 , A61L24/0084 , A61L27/46
摘要： A process for the production of a composite material comprising collagen, brushite and one or more glycosaminoglycans, said process comprising the steps of providing an acidic aqueous solution comprising collagen, a calcium source and a phosphorous source and one or more glycosaminoglycans, and precipitating the collagen, the brushite and the one or more glycosaminoglycans together from the aqueous solution to form a triple co-precipitate.
摘要翻译： 一种生产复合材料的方法，该复合材料包括胶原蛋白，褐铁矿和一种或多种糖胺聚糖，所述方法包括以下步骤：提供包含胶原蛋白，钙源和磷源和一种或多种糖胺聚糖的酸性水溶液，并沉淀胶原蛋白 ，水凝胶和一种或多种糖胺聚糖一起从水溶液中形成三重共沉淀物。
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公开(公告)号：US06390469B1
公开(公告)日：2002-05-21
申请号：US09702012
申请日：2000-10-30
IPC分类号： B65H3910
CPC分类号： B65H39/02 , B65H2301/4321 , B65H2403/41 , B65H2403/47 , B65H2403/722 , B65H2511/15 , B65H2511/22 , B65H2220/01 , B65H2220/02 , B65H2220/11 , B65H2220/04
摘要： A sheet material conveying apparatus includes a plurality of pockets, each pocket including a setting device for adjusting a height of the pocket when the pocket is stationary so as to define a set height, the setting device including a setting rod, a ring gear having an outer surface connected to the setting rod, and a lock ring selectively releasable from the ring gear, the setting rod including a disengaging device for releasing the lock ring from the ring gear during a setting operation. A method and a sheet material pocket are also provided.
摘要翻译： 片材输送装置包括多个袋，每个袋包括一个调节装置，用于当袋静止时调节袋的高度以限定设定的高度，该设定装置包括一设定杆， 外表面连接到设置杆，以及锁定环，其可选择性地从所述环形齿轮释放，所述调整杆包括用于在设定操作期间将所述锁定环从所述环形齿轮释放的分离装置。 还提供了一种方法和片材袋。
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