公开(公告)号：US20100173042A1

公开(公告)日：2010-07-08

申请号：US12653594

申请日：2009-12-14

申请人： Andrew McShea ,  Andrew Mark Morotti

发明人： Andrew McShea ,  Andrew Mark Morotti

IPC分类号： A23G1/32 ,  A23G1/56 ,  A23L1/28

CPC分类号： A23G1/32 ,  A23G1/0003 ,  A23G1/0006 ,  A23G1/0009 ,  A23G1/0036 ,  A23G1/30 ,  A23G1/56 ,  A23L2/52 ,  A23L33/105

摘要： Disclosed herein are a chocolate extract and a process of making the extract. The process comprises mixing a chocolate source with a water miscible solution. The chocolate source and water miscible solution are at a temperature where the chocolate source is in a liquid state during mixing. The water miscible solution and the chocolate form a mixture of a water miscible phase, an oil phase, and a solid particle phase. The mixing allows the water miscible components to migrate into the water miscible phase. The mixture is separated to recover the water phase from the oil phase and the solid particle phase. This water miscible phase is the extract of chocolate.

摘要翻译： 本文公开了巧克力提取物和制备提取物的方法。 该方法包括将巧克力源与水混溶的溶液混合。 巧克力源和水可混溶的溶液处于巧克力源在混合期间处于液态的温度。 水混溶溶液和巧克力形成水混溶相，油相和固相颗粒相的混合物。 混合允许水混溶组分迁移到水混溶相中。 分离混合物以从油相和固体颗粒相中回收水相。 这种水混溶相是巧克力的提取物。

公开(公告)号：US20060015264A1

公开(公告)日：2006-01-19

申请号：US10860095

申请日：2004-06-02

申请人： Andrew McShea ,  Andrew Antoniewicz

发明人： Andrew McShea ,  Andrew Antoniewicz

IPC分类号： G01N33/48 ,  G01N33/50 ,  G06F19/00

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N2310/141 ,  C12N2320/11 ,  C12N2330/10 ,  G16B15/00 ,  G16B20/00

摘要： A method for identifying stem-loop structures within a genome is provided. A plurality of stem-loop structures, compounds of stem-loop structures, pharmaceutical compositions of stem-loop structures, and treatment methods for affecting a condition or disease in an organism using stem-loop structures is provided. The method is for rapidly identifying and screening small inhibitory stem-loop structures of RNA or DNA sequences of any genome, wherein those sequences or combinations thereof can be administered to obtain a desirable biological affect in a human or other organism for treatment of a condition or a disease. The method is used for rapidly identifying and screening small inhibitory stem-loop structures of a viral RNA (viRNA), wherein the viRNA's prevents death in transfected cells programmed for cell death thus providing siRNA-type compositions for use in treating inflammatory conditions in humans or other species.

摘要翻译： 提供了用于鉴定基因组内的茎 - 环结构的方法。 提供了多个茎环结构，茎 - 环结构的化合物，茎 - 环结构的药物组合物和用于使用茎 - 环结构影响生物体中的病症或疾病的治疗方法。 该方法用于快速鉴定和筛选任何基因组的RNA或DNA序列的小抑制性茎环结构，其中可以施用那些序列或其组合以在人或其他生物体中获得理想的生物学作用，用于治疗病症或 疾病。 该方法用于快速鉴定和筛选病毒RNA（viRNA）的小抑制性茎 - 环结构，其中viRNA可防止编程细胞死亡的转染细胞中的死亡，从而提供用于治疗人类炎症性病症的siRNA型组合物， 其他物种

公开(公告)号：US07510871B2

公开(公告)日：2009-03-31

申请号：US10414829

申请日：2003-04-15

申请人： Mark A. Smith ,  Andrew McShea

发明人： Mark A. Smith ,  Andrew McShea

IPC分类号： C12N5/00

CPC分类号： G01N33/5058 ,  C12Q1/485 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/6896 ,  G01N2800/52

摘要： The present invention relates to methods and reagents for drug screening. Screening methods are disclosed employing neuronal cells that have been treated so as to exhibit characteristics associated with a re-entry into the cell cycle. One treatment approach comprises transfection of neuronal cells with an expression vector comprising one or more oncogenes.

摘要翻译： 本发明涉及用于药物筛选的方法和试剂。 公开了筛选方法，其使用已经被处理以显示与重新进入细胞周期相关联的特征的神经元细胞。 一种治疗方法包括用包含一种或多种癌基因的表达载体转染神经元细胞。

公开(公告)号：US06548261B1

公开(公告)日：2003-04-15

申请号：US09223588

申请日：1998-12-30

申请人： Mark A. Smith ,  Andrew McShea

发明人： Mark A. Smith ,  Andrew McShea

IPC分类号： G01N3353

CPC分类号： G01N33/5058 ,  C12Q1/485 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/6896 ,  G01N2800/52

摘要： The present invention relates to methods and reagents for drug screening. Screening methods are disclosed employing neuronal cells that have been treated so as to exhibit characteristics associated with a re-entry into the cell cycle. One treatment approach comprises transfection of neuronal cells with an expression vector comprising one or more oncogenes.