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1.发明申请N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE 有权作为吲哚胺2,3-二氧化物的调节剂的N-羟基甲酰胺公开(公告)号：US20110165188A1
公开(公告)日：2011-07-07
申请号：US13050143
申请日：2011-03-17
IPC分类号： A61K39/12 , C07D261/14 , A61K31/42 , A61K39/00 , C07D333/70 , A61K31/381 , C07D307/52 , A61K31/341 , C07D413/12 , A61K31/496 , C07D413/04 , A61K31/5377 , A61P35/00 , A61P31/12 , A61P37/04 , C07D261/20 , A61K31/423 , C12N9/99 , A61P37/06 , A61P35/02
CPC分类号： C07D261/18 , C07D261/20 , C07D307/68 , C07D333/70
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
摘要翻译： 本发明涉及作为吲哚胺2,3-双加氧酶（IDO）的调节剂的N-羟基脒基化合物及其组合物和药物方法。
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公开(公告)号：US20110172279A1
公开(公告)日：2011-07-14
申请号：US13070069
申请日：2011-03-23
IPC分类号： A61K31/427 , C07D417/04 , C12N9/99 , A61P35/00 , A61P27/12 , A61P37/06 , A61P35/02 , C07D261/18 , A61K31/42 , C07D277/56 , A61K31/426 , C07D261/20 , A61K31/423
CPC分类号： C07D413/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D417/04
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
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公开(公告)号：US20080125470A1
公开(公告)日：2008-05-29
申请号：US11856967
申请日：2007-09-18
IPC分类号： A61K31/426 , A61P35/00 , C07D261/06 , A61K31/41 , C07D249/04 , A61K31/42 , C07D277/20
CPC分类号： C07D413/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D417/04
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
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公开(公告)号：US08377976B2
公开(公告)日：2013-02-19
申请号：US13070069
申请日：2011-03-23
IPC分类号： A61K31/425 , A61K31/42
CPC分类号： C07D413/04 , C07D261/18 , C07D261/20 , C07D277/56 , C07D417/04
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
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5.发明申请N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE 审中-公开作为吲哚胺2,3-二氧化物的调节剂的N-羟基甲酰胺公开(公告)号：US20080214546A1
公开(公告)日：2008-09-04
申请号：US11856982
申请日：2007-09-18
IPC分类号： A61K31/5377 , C07D261/12 , A61K31/42 , C12N9/99 , A61P31/12 , A61P37/00 , A61P35/00 , C12N9/04 , C07D413/04
CPC分类号： C07D261/18 , C07D261/20 , C07D307/68 , C07D333/70
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
摘要翻译： 本发明涉及作为吲哚胺2,3-双加氧酶（IDO）的调节剂的N-羟基脒基化合物及其组合物和药物方法。
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6.发明授权N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase 有权N-羟基脒基杂环作为吲哚胺2,3-双加氧酶的调节剂公开(公告)号：US08507541B2
公开(公告)日：2013-08-13
申请号：US13050143
申请日：2011-03-17
IPC分类号： A61K31/42 , C07D261/04 , C07D261/14 , C07D261/06
CPC分类号： C07D261/18 , C07D261/20 , C07D307/68 , C07D333/70
摘要： The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
摘要翻译： 本发明涉及作为吲哚胺2,3-双加氧酶（IDO）的调节剂的N-羟基脒基化合物及其组合物和药物方法。
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7.发明授权N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors 有权N-（1-（取代苯基）乙基）-9H-嘌呤-6-胺作为PI3K抑制剂公开(公告)号：US09096600B2
公开(公告)日：2015-08-04
申请号：US13329532
申请日：2011-12-19
IPC分类号： C07D473/34 , C07D473/32
CPC分类号： C07D473/34 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/32
摘要： The present invention provides N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines derivatives that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
摘要翻译： 本发明提供了调节磷酸肌醇3-激酶（PI3K）活性的N-（1-（取代苯基）乙基）-9H-嘌呤-6-胺衍生物，可用于治疗与 PI3Ks包括例如炎症性疾病，基于免疫的疾病，癌症和其它疾病。
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公开(公告)号：US20140031344A1
公开(公告)日：2014-01-30
申请号：US14032629
申请日：2013-09-20
申请人： Argyrios G. Arvanitis , James D. Rodgers , Andrew P. Combs , Richard B. Sparks , Darius J. Robinson , Jordan S. Fridman , Krishna Vaddi
发明人： Argyrios G. Arvanitis , James D. Rodgers , Andrew P. Combs , Richard B. Sparks , Darius J. Robinson , Jordan S. Fridman , Krishna Vaddi
IPC分类号： C07D471/14 , C07D471/22
CPC分类号： C07D471/14 , C07D471/22 , C07D487/14 , C07D487/22
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶活性相关的疾病，包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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公开(公告)号：US08563541B2
公开(公告)日：2013-10-22
申请号：US13479045
申请日：2012-05-23
申请人： Argyrios G. Arvanitis , James D. Rodgers , Andrew P. Combs , Richard B. Sparks , Darius J. Robinson
发明人： Argyrios G. Arvanitis , James D. Rodgers , Andrew P. Combs , Richard B. Sparks , Darius J. Robinson
IPC分类号： A61K31/55 , C07D471/22
CPC分类号： C07D471/14 , C07D471/22 , C07D487/14 , C07D487/22
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶活性相关的疾病，包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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公开(公告)号：US20120329782A1
公开(公告)日：2012-12-27
申请号：US13479045
申请日：2012-05-23
申请人： Argyrios G. Arvanitis , James D. Rodgers , Andrew P. Combs , Richard B. Sparks , Darius J. Robinson , Jordan S. Fridman , Krishna Vaddi
发明人： Argyrios G. Arvanitis , James D. Rodgers , Andrew P. Combs , Richard B. Sparks , Darius J. Robinson , Jordan S. Fridman , Krishna Vaddi
IPC分类号： C07D487/22 , A61P37/00 , A61P17/00 , A61P19/02 , A61P35/02 , A61P37/02 , A61P1/04 , A61P37/08 , A61P31/12 , A61P35/04 , A61K31/55 , A61P3/10
CPC分类号： C07D471/14 , C07D471/22 , C07D487/14 , C07D487/22
摘要： The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.
摘要翻译： 本发明提供调节Janus激酶活性的化合物，并且可用于治疗与Janus激酶活性相关的疾病，包括例如免疫相关疾病，皮肤病，骨髓增生性疾病，癌症和其它疾病。
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